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Patricia A. Thistlethwaite
Michael M. Madani
David P. Kapelanski
Stuart W. Jamieson
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Ann Thorac Surg 2001;72:13-18
© 2001 The Society of Thoracic Surgeons

Original article: cardiovascular

Pulmonary thromboendarterectomy combined with other cardiac operations: indications, surgical approach, and outcome

Patricia A. Thistlethwaite, MD, PhDa, William R. Auger, MDb, Michael M. Madani, MDa, Sujit Pradhan, BSa, David P. Kapelanski, MDa, Stuart W. Jamieson, MB, FRCSa a Division of Cardiothoracic Surgery, University of California, San Diego, San Diego, California, USA
b Division of Pulmonary and Critical Care Medicine, University of California, San Diego, San Diego, California, USA

Address reprint requests to Dr Thistlethwaite, Division of Cardiothoracic Surgery, University of California, San Diego, 200 West Arbor Dr, San Diego, CA 92103-8892
e-mail: pthistlethwaite{at}ucsd.edu

Presented at the Thirty-seventh Annual Meeting of The Society of Thoracic Surgeons, New Orleans, LA, Jan 29–31, 2001.

Background. Patients with pulmonary hypertension due to chronic thromboembolic disease benefit from pulmonary thromboendarterectomy. A subset of these patients present with concomitant coronary or valvular disease.

Methods. From July 1990 to July 2000, 90 patients (68 males, 22 females, mean age 68 years) with pulmonary vascular resistance (PVR) ranging from 297 to 2261 dynes · sec · cm-5 underwent pulmonary thromboendarterectomy in conjunction with coronary bypass grafting (59 patients), coronary artery bypass grafting/foramen ovale closure (24 patients), tricuspid annuloplasty (3 patients), mitral valve repair (2 patients), and aortic valve replacement (2 patients). The perioperative and hemodynamic outcomes of these patients were compared with the cohort of 1,100 isolated pulmonary thromboendarterectomies performed at our institution during this time.

Results. Overall perioperative survival (93.3%; 84 of 90 patients) and mean diminution in PVR (521 dynes · sec · cm-5) for patients undergoing combined operations were similar to those undergoing pulmonary thromboendarterectomy alone (94.2% survival; 1034 of 1100 patients; 547 dynes · sec · cm-5 mean PVR reduction). Although patients undergoing combined operations were older (mean age 68 vs 50 years, p < 0.0001), had longer hospital stays (median 14 vs 9 days), and had worse left ventricular function (mean preoperative cardiac output 3.1 vs 4.4, p < 0.0001), there was no difference in cross-clamp time, resolution of tricuspid regurgitation, or postoperative systolic function between these two groups.

Conclusions. Pulmonary thromboendarterectomy for chronic thromboembolic pulmonary hypertension may be performed safely in conjunction with other cardiac operations. Older patients evaluated for pulmonary thromboendarterectomy should be screened for concomitant coronary and valvular disease.


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