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Ann Thorac Surg 2001;71:2066-2074
© 2001 The Society of Thoracic Surgeons

Current review

Therapeutic implications of inflammation in atherosclerotic cardiovascular disease

Craig H. Selzman, MDa, Stephanie A. Miller, MDa, Alden H. Harken, MDa

a Division of Cardiothoracic Surgery, Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado, USA

Address reprint requests to Dr Selzman, Department of Surgery, University of Colorado Health Sciences Center, Box C-310, 4200 East Ninth Ave, Denver, CO 80262
e-mail: craig.selzman{at}uchsc.edu

Atherosclerosis represents a spectrum of pathologic lesions with diverse clinical sequelae. In this review, we build upon the paradigm that arteriosclerosis represents an inflammatory disease. By examining mechanisms involved in the response to vascular injury, we can more effectively implement targeted therapy aimed at halting or regressing arteriosclerosis.




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