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Ann Thorac Surg 2001;71:S417-S421
© 2001 The Society of Thoracic Surgeons

Basic research

Tissue characterization and calcification potential of commercial bioprosthetic heart valves

Crystal M. Cunanan, MSa, Christine M. Cabiling, BSa, Tan T. Dinh, BSa, ShihHwa Shen, BSa, Phihoa Tran-Hata, BSa, James H. Rutledge, III, PhDa, Michael C. Fishbein, MDb

a Heart Valve Therapy Research, Edwards Lifesciences, Irvine, California, USA
b UCLA Center for Health Sciences, Department of Pathology and Laboratory Medicine, Los Angeles, California, USA

Address reprint requests to Ms Cunanan, Edwards Lifesciences, Heart Valve Therapy Research, One Edwards Way, Irvine, CA 92614
e-mail: crystal_cunanan{at}edwards.com

Presented at the VIII International Symposium on Cardiac Bioprostheses, Cancun, Mexico, Nov 3–5, 2000.

Background. Tissue properties may contribute to intrinsic calcification of bioprosthetic heart valves. Phospholipids have been proposed as potential nucleation sites for calcification. Other tissue properties might also be important in calcification.

Methods. Commercial and control bioprosthetic valve tissues were characterized by shrinkage temperature, moisture content, free amine content, phospholipid content, and calcification level after 90-day rat subcutaneous implantation as described.

Results. Shrinkage temperature, moisture content, and free amine content were typical for glutaraldehyde–cross-linked tissues. Phospholipid and calcium levels varied considerably among valve types. There was a significant correlation between phospholipid levels and calcification (r = 0.63, p = 0.04). Sulzer Carbomedics Mitroflow and Toronto SPV valve tissues had significantly more calcification than other commercial bioprostheses in this study (p < 0.01). Carpentier-Edwards Duraflex, CE SAV, and CE PERIMOUNT valve tissues had significantly less calcification than Medtronic Mosaic in this animal model (p < 0.02).

Conclusions. Processes that reduce phospholipid levels are associated with reduced calcification in the rat subcutaneous model. Significant differences in calcification level were found among commercially available valves. The clinical significance of these results is unknown.




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