ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
John C Wain
David W Johnstone
Stephen C Yang
Cameron D Wright
Joseph S Friedberg
Richard H Feins
Douglas J Mathisen
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wain, J. C.
Right arrow Articles by Selwyn, M. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wain, J. C.
Right arrow Articles by Selwyn, M. R.

Ann Thorac Surg 2001;71:1623-1629
© 2001 The Society of Thoracic Surgeons

Original article: general thoracic

Trial of a novel synthetic sealant in preventing air leaks after lung resection

John C Wain, MDa,*, Larry R Kaiser, MDb, David W Johnstone, MDc, Stephen C Yang, MDd, Cameron D Wright, MDa, Joseph S Friedberg, MDb, Richard H Feins, MDc, Richard F Heitmiller, MDd, Douglas J Mathisen, MDa, Murray R Selwyn, PhDe

a Division of General Thoracic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
b Department of General Thoracic Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
c Department of Cardiothoracic Surgery, Strong Memorial Hospital, University of Rochester Medical Center, Rochester, New York, USA
d Division of Thoracic Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
e Statistics Unlimited, Savannah, Georgia, USA

* Address reprint requests to Dr Wain, Department of Thoracic Surgery, Massachusetts General Hospital, Blake 1570, 55 Fruit St, Massachusetts General Hospital, Boston MA 02114 (Email: Jwain{at}partners.org).

Presented at the Thirty-sixth Annual Meeting of The Society of Thoracic Surgeons, Fort Lauderdale, FL, Jan 31–Feb 2, 2000.

Background. Postoperative air leaks are a major cause of morbidity after lung resections. This study was designed to evaluate the efficacy and safety of a new synthetic, bioresorbable surgical sealant in preventing air leaks after pulmonary resection.

Methods. In a multicenter trial, 172 patients undergoing thoracotomy were randomized intraoperatively in a 2:1 ratio to receive surgical sealant applied to sites at risk for air leak after standard methods of lung closure (treatment group) or to have standard lung closure only (control group). The primary outcome variable was the percentage of patients free of air leakage throughout hospitalization. Secondary outcome variables were the control of air leaks intraoperatively and the time to postoperative air leak cessation. Time to chest tube removal, time to hospital discharge, and safety outcomes were also evaluated.

Results. Air leaks were identified before randomization in 89 of 117 patients in the treatment group and in 39 of 55 patients in the control group. Application of the sealant resulted in control of air leaks in 92% of treated patients (p ≤ 0.001). A significantly higher percentage of treated patients than control patients remained free of air leaks during hospitalization (39% versus 11%, p ≤ 0.001). The mean times to last observable air leak were 30.9 hours in the treatment group and 52.3 hours in the control group (p = 0.006). In the treatment group, trends were observed for reduced time to chest tube removal and earlier discharge. No significant difference was identified in postoperative morbidity and mortality between the two groups.

Conclusions. Air leaks after lung resection occur in most patients. The application of this novel surgical sealant appears to be effective and safe in preventing postoperative air leaks.




This article has been cited by other articles:


Home page
 Sci Transl MedHome page
A. T. Hillel, S. Unterman, Z. Nahas, B. Reid, J. M. Coburn, J. Axelman, J. J. Chae, Q. Guo, R. Trow, A. Thomas, et al.
Photoactivated Composite Biomaterial for Soft Tissue Restoration in Rodents and in Humans
Science Translational Medicine, July 27, 2011; 3(93): 93ra67 - 93ra67.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
P. De Leyn, M.-R. Muller, J. W. A. Oosterhuis, T. Schmid, C. K. C. Choong, W. Weder, and Y. Sokolow
Prospective European multicenter randomized trial of PleuraSeal for control of air leaks after elective pulmonary resection
J. Thorac. Cardiovasc. Surg., April 1, 2011; 141(4): 881 - 887.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
G. Malapert, H. A. Hanna, P. B. Pages, and A. Bernard
Surgical Sealant for the Prevention of Prolonged Air Leak After Lung Resection: Meta-Analysis
Ann. Thorac. Surg., December 1, 2010; 90(6): 1779 - 1785.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
S. Singhal and J. B. Shrager
Should buttresses and sealants be used to manage pulmonary parenchymal air leaks?
J. Thorac. Cardiovasc. Surg., December 1, 2010; 140(6): 1220 - 1225.
[Full Text] [PDF]

Home page
 Eur J Cardiothorac SurgHome page
G. M. Marta, F. Facciolo, L. Ladegaard, H. Dienemann, A. Csekeo, F. Rea, S. Dango, L. Spaggiari, V. Tetens, and W. Klepetko
Efficacy and safety of TachoSil(R) versus standard treatment of air leakage after pulmonary lobectomy,
Eur J Cardiothorac Surg, December 1, 2010; 38(6): 683 - 689.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
E. Belcher, M. Dusmet, S. Jordan, G. Ladas, E. Lim, and P. Goldstraw
A prospective, randomized trial comparing BioGlue and Vivostat for the control of alveolar air leak.
J. Thorac. Cardiovasc. Surg., July 1, 2010; 140(1): 32 - 38.
[Abstract] [Full Text] [PDF]

Home page
 Surgery for Non-Neoplastic Disorders of the Chest: a Clinical UpdateHome page
T. C. Mineo, E. Pompeo, H. B. Ris, W. Weder, P. Evrard, G. Massard, and N. Konietzko
Surgery for emphysema: surgical aspects
Surgery for Non-Neoplastic Disorders of the Chest: a Clinical Update, June 28, 2010; 113 - 128.
[Abstract] [Fulltext] [PDF]

Home page
 Ann. Thorac. Surg.Home page
M. Liberman, A. Muzikansky, C. D. Wright, J. C. Wain, D. M. Donahue, J. S. Allan, H. A. Gaissert, C. R. Morse, D. J. Mathisen, and M. Lanuti
Incidence and Risk Factors of Persistent Air Leak After Major Pulmonary Resection and Use of Chemical Pleurodesis
Ann. Thorac. Surg., March 1, 2010; 89(3): 891 - 898.
[Abstract] [Full Text] [PDF]

Home page
 Interact CardioVasc Thorac SurgHome page
O. Rena, E. Papalia, T. C. Mineo, F. Massera, E. Pirondini, D. Turello, and C. Casadio
Air-leak management after upper lobectomy in patients with fused fissure and chronic obstructive pulmonary disease: a pilot trial comparing sealant and standard treatment
Interact CardioVasc Thorac Surg, December 1, 2009; 9(6): 973 - 977.
[Abstract] [Full Text] [PDF]

Home page
 Interact CardioVasc Thorac SurgHome page
G. Rocco, E. A. Rendina, F. Venuta, M. R. Mueller, S. Halezeroglu, H. Dienemann, D. V. Raemdonck, and H. J. Hansen
The use of sealants in modern thoracic surgery: a survey
Interact CardioVasc Thorac Surg, July 1, 2009; 9(1): 1 - 3.
[Full Text] [PDF]

Home page
 Eur J Cardiothorac SurgHome page
A. D'Andrilli, C. Andreetti, M. Ibrahim, A. M. Ciccone, F. Venuta, U. Mansmann, and E. A. Rendina
A prospective randomized study to assess the efficacy of a surgical sealant to treat air leaks in lung surgery
Eur J Cardiothorac Surg, May 1, 2009; 35(5): 817 - 821.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
A. Droghetti, A. Schiavini, and G. Muriana
Reply to the Editor:
J. Thorac. Cardiovasc. Surg., February 1, 2009; 137(2): 507 - 508.
[Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
C. Moser, I. Opitz, W. Zhai, V. Rousson, E.W. Russi, W. Weder, and D. Lardinois
Autologous fibrin sealant reduces the incidence of prolonged air leak and duration of chest tube drainage after lung volume reduction surgery: a prospective randomized blinded study.
J. Thorac. Cardiovasc. Surg., October 1, 2008; 136(4): 843 - 849.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
A. Droghetti, A. Schiavini, P. Muriana, A. Folloni, M. Picarone, C. Bonadiman, C. Sturani, R. Paladini, and G. Muriana
A prospective randomized trial comparing completion technique of fissures for lobectomy: stapler versus precision dissection and sealant.
J. Thorac. Cardiovasc. Surg., August 1, 2008; 136(2): 383 - 391.
[Abstract] [Full Text] [PDF]

Home page
 Interact CardioVasc Thorac SurgHome page
U. Anegg, R. Rychlik, and F. Smolle-Juttner
Do the benefits of shorter hospital stay associated with the use of fleece-bound sealing outweigh the cost of the materials?
Interact CardioVasc Thorac Surg, April 1, 2008; 7(2): 292 - 296.
[Abstract] [Full Text] [PDF]

Home page
 Interact CardioVasc Thorac SurgHome page
S. Rathinam and R. S. Steyn
Management of complicated postoperative air-leak - a new indication for the Asherman chest seal
Interact CardioVasc Thorac Surg, December 1, 2007; 6(6): 691 - 694.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
M. Araki, H. Tao, N. Nakajima, H. Sugai, T. Sato, S.-H. Hyon, T. Nagayasu, and T. Nakamura
Development of new biodegradable hydrogel glue for preventing alveolar air leakage.
J. Thorac. Cardiovasc. Surg., November 1, 2007; 134(5): 1241 - 1248.
[Abstract] [Full Text] [PDF]

Home page
 Interact CardioVasc Thorac SurgHome page
J. Tambiah, R. Rawlins, D. Robb, and T. Treasure
Can tissue adhesives and glues significantly reduce the incidence and length of postoperative air leaks in patients having lung resections?
Interact CardioVasc Thorac Surg, August 1, 2007; 6(4): 529 - 533.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
M. Araki, H. Tao, T. Sato, N. Nakajima, H. Sugai, S.-H. Hyon, T. Nagayasu, and T. Nakamura
Creation of a uniform pleural defect model for the study of lung sealants
J. Thorac. Cardiovasc. Surg., July 1, 2007; 134(1): 145 - 151.
[Abstract] [Full Text] [PDF]

Home page
 Interact CardioVasc Thorac SurgHome page
M. Gika, M. Kawamura, Y. Izumi, and K. Kobayashi
The short-term efficacy of fibrin glue combined with absorptive sheet material in visceral pleural defect repair
Interact CardioVasc Thorac Surg, February 1, 2007; 6(1): 12 - 15.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Cardiothorac SurgHome page
L. Dernevik, A. Belboul, and G. Radberg
Initial experience with the world's first digital drainage system. The benefits of recording air leaks with graphic representation
Eur J Cardiothorac Surg, February 1, 2007; 31(2): 209 - 213.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
F. Venuta, D. Diso, T. De Giacomo, M. Anile, E. A. Rendina, and G. F. Coloni
Use of a polymeric sealant to reduce air leaks after lobectomy.
J. Thorac. Cardiovasc. Surg., August 1, 2006; 132(2): 422 - 423.
[Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
P. Tansley, F. Al-Mulhim, E. Lim, G. Ladas, and P. Goldstraw
A prospective, randomized, controlled trial of the effectiveness of BioGlue in treating alveolar air leaks
J. Thorac. Cardiovasc. Surg., July 1, 2006; 132(1): 105 - 112.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Cardiothorac SurgHome page
P. Thomas, G. Massard, H. Porte, C. Doddoli, X. Ducrocq, and M. Conti
A new bioabsorbable sleeve for lung staple-line reinforcement (FOREsealTM) report of a three-center phase II clinical trial
Eur J Cardiothorac Surg, June 1, 2006; 29(6): 880 - 885.
[Full Text] [PDF]

Home page
 Eur J Cardiothorac SurgHome page
U. Anegg, J. Lindenmann, V. Matzi, D. Mujkic, A. Maier, L. Fritz, and F. M. Smolle-Juttner
AIRFIX(R): the first digital postoperative chest tube airflowmetry--a novel method to quantify air leakage after lung resection
Eur J Cardiothorac Surg, June 1, 2006; 29(6): 867 - 872.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
I. Matsumoto, Y. Ohta, M. Oda, Y. Tsunezuka, M. Tamura, K. Kawakami, and G. Watanabe
Free Pericardial Fat Pads Can Act as Sealant for Preventing Alveolar Air Leaks
Ann. Thorac. Surg., December 1, 2005; 80(6): 2321 - 2324.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Cardiothorac SurgHome page
M. Kawamura, M. Gika, Y. Izumi, H. Horinouchi, N. Shinya, M. Mukai, and K. Kobayashi
The sealing effect of fibrin glue against alveolar air leakage evaluated up to 48 h; comparison between different methods of application
Eur J Cardiothorac Surg, July 1, 2005; 28(1): 39 - 42.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
I. Okereke, S. C. Murthy, J. M. Alster, E. H. Blackstone, and T. W. Rice
Characterization and Importance of Air Leak After Lobectomy
Ann. Thorac. Surg., April 1, 2005; 79(4): 1167 - 1173.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Cardiothorac SurgHome page
G. Varela, M. F. Jimenez, N. Novoa, and J. L. Aranda
Estimating hospital costs attributable to prolonged air leak in pulmonary lobectomy
Eur J Cardiothorac Surg, February 1, 2005; 27(2): 329 - 333.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
M. S. Allen, D. E. Wood, R. W. Hawkinson, D. H. Harpole, R. J. McKenna, G. L. Walsh, E. Vallieres, D. L. Miller, F. C. Nichols III, W. R. Smythe, et al.
Prospective randomized study evaluating a biodegradable polymeric sealant for sealing intraoperative air leaks that occur during pulmonary resection
Ann. Thorac. Surg., May 1, 2004; 77(5): 1792 - 1801.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. A. Keller
Lasers, Staples, Bovine Pericardium, Talc, Glue and... Suction Cylinders?: Tools of the Trade To Avoid Air Leaks in Lung Volume Reduction Surgery
Chest, February 1, 2004; 125(2): 361 - 363.
[Full Text] [PDF]

Home page
 Eur J Cardiothorac SurgHome page
G. Lang, A. Csekeo, G. Stamatis, L. Lampl, L. Hagman, G. M. Marta, M. R. Mueller, and W. Klepetko
Efficacy and safety of topical application of human fibrinogen/thrombin-coated collagen patch (TachoComb) for treatment of air leakage after standard lobectomy
Eur J Cardiothorac Surg, February 1, 2004; 25(2): 160 - 166.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
K. Ueda, Y. Kaneda, H. Sakano, T. Tanaka, T.-S. Li, and K. Hamano
Obstacles for shortening hospitalization after video-assisted pulmonary resection for lung cancer
Ann. Thorac. Surg., December 1, 2003; 76(6): 1816 - 1820.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
E. Vallieres, X. Gonzalez, K. M. Pedersen, G. K. Sears, and S. C. Springmeyer
Novel surgical system for reducing lung tissue and preventing air leaks
Ann. Thorac. Surg., December 1, 2003; 76(6): 2071 - 2074.
[Abstract] [Full Text] [PDF]

Home page
 Interact CardioVasc Thorac SurgHome page
F. Chen, M. Nakai, A. Aoyama, N. Isowa, and K. Chihara
Diaphragmatic elevation of a patient with chronic obstructive pulmonary disease after left upper lobectomy
Interact CardioVasc Thorac Surg, December 1, 2003; 2(4): 688 - 691.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
M. Margolis, F. Gharagozloo, B. Tempesta, G. D. Trachiotis, N. M. Katz, and E. P. Alexander
Video-assisted thoracic surgical treatment of initial spontaneous pneumothorax in young patients
Ann. Thorac. Surg., November 1, 2003; 76(5): 1661 - 1664.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
F. Gharagozloo, B. Tempesta, M. Margolis, and E. P. Alexander
Video-assisted thoracic surgery lobectomy for Stage I lung cancer
Ann. Thorac. Surg., October 1, 2003; 76(4): 1009 - 1015.
[Abstract] [Full Text] [PDF]

Home page
 Interact CardioVasc Thorac SurgHome page
A. E. Martin-Ucar, E. Passera, R. Vaughan, and G. Rocco
Implementation of a user-friendly protocol for interpretation of air-leaks and management of intercostal chest drains after thoracic surgery
Interact CardioVasc Thorac Surg, September 1, 2003; 2(3): 251 - 255.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
T. Fabian, J. A. Federico, and R. B. Ponn
Fibrin glue in pulmonary resection: a prospective, randomized, blinded study
Ann. Thorac. Surg., May 1, 2003; 75(5): 1587 - 1592.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
R. J. Cerfolio, C. S. Bass, A. H. Pask, and C. R. Katholi
Predictors and treatment of persistent air leaks
Ann. Thorac. Surg., June 1, 2002; 73(6): 1727 - 1731.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
T. De Giacomo, E. A. Rendina, F. Venuta, F. Francioni, M. Moretti, F. Pugliese, and G. F. Coloni
Pneumoperitoneum for the management of pleural air space problems associated with major pulmonary resections
Ann. Thorac. Surg., November 1, 2001; 72(5): 1716 - 1719.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2001 by The Society of Thoracic Surgeons.