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Ann Thorac Surg 2001;71:1603-1608
© 2001 The Society of Thoracic Surgeons

Original article: cardiovascular

Efficacy of a new coating material, PMEA, for cardiopulmonary bypass circuits in a porcine model

Hitoshi Suhara, MDa, Yoshiki Sawa, MDa, Motonobu Nishimura, MDa, Hiroaki Oshiyama, B Engb, Kenji Yokoyama, B Engb, Noboru Saito, B Engb, Hikaru Matsuda, MDa

a Division of Cardiovascular Surgery, Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
b Research and Development, Terumo Corporation, Tokyo, Japan

Accepted for publication January 19, 2001.

Address reprint requests to Dr Sawa, Division of Cardiovascular Surgery, Department of Surgery, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan
e-mail: sawa{at}surg1.med.osaka-u.ac.jp

Background. A new coating material, poly-2-methoxyethyl acrylate (PMEA), was developed to improve the biocompatibility of cardiopulmonary bypass (CPB) circuits.

Methods. To investigate the efficacy of the PMEA coating for CPB circuits, we compared PMEA-coated circuits (group P, n = 6) with uncoated circuits (group C, n = 6) and heparin (covalent-bonded heparin, Hepaface)-coated circuits (group H, n = 6) in a porcine CPB model.

Results. Platelet counts were significantly preserved in groups P and H compared with those in group C (P versus C, p < 0.05). The plasma levels of thrombin-antithrombin complex and bradykinin were significantly lower at 120 minutes in groups P and H than in group C (thrombin-antithrombin: P versus C, p < 0.05; bradykinin: P versus C, p < 0.05). The amount of fibrinogen adsorbed onto the hollow fibers was markedly less in group P than in groups C and H.

Conclusions. The PMEA coating was equal to heparin coating in preventing reactions induced by CPB circuits, and might be superior to heparin coating in suppressing the adsorption of plasma proteins such as fibrinogen. Thus, PMEA coating may be a suitable means for improving the biocompatibility of CPB circuits.




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