| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 2001;71:1512-1517
© 2001 The Society of Thoracic Surgeons
a Department of Cardiothoracic Anaesthetics and Intensive Care, Karolinska Hospital, Stockholm, Sweden
b Department of Clinical Chemistry, Karolinska Hospital, Stockholm, Sweden
c Department of Thoracic Surgery, Karolinska Hospital, Stockholm, Sweden
d CanAg Diagnostics AB, Gothenburg, Sweden
Accepted for publication December 13, 2000.
Address reprint requests to Dr Anderson, Department of Cardiothoracic Anaesthetics and Intensive Care, Karolinska Hospital, S-171 76 Stockholm, Sweden
e-mail: russell.anderson{at}kirurgi.ki.se
Background. Elevated levels of serum S100B after coronary artery bypass grafting may arise from extracerebral contamination. Serum S100B content was analyzed in several tissues, and the two dimers S100A1-B and S100BB were analyzed separately in blood.
Methods. Serum, shed blood, marrow, fat, and muscle were studied in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass using suction either to the cardiotomy reservoir (group 1, n = 10) or to a cell-saving device (group 2, n = 10), or operated on off-pump (group 3, n = 10).
Results. Serum S100B was sixfold higher in group 1 than in groups 2 and 3, which were identical. The same ratio between S100A1-B and S100BB was found in all groups. When compared with serum, S100B was 102 to 104 times higher in marrow, fat, muscle tissue, and shed blood.
Conclusions. Separate analysis of S100A1-B and S100BB did not distinguish between S100B of cerebral and extracerebral origin. The concept that S100B only originates in astroglial and Schwann cells is wrong. Fat, muscle, and marrow in mediastinal blood contain high levels of S100B. Cardiopulmonary bypass caused no increase in S100B.
This article has been cited by other articles:
|
|
 |
|
  M Olivecrona, M Rodling-Wahlstrom, S Naredi, and L-O D Koskinen S-100B and neuron specific enolase are poor outcome predictors in severe traumatic brain injury treated by an intracranial pressure targeted therapy J. Neurol. Neurosurg. Psychiatry, November 1, 2009; 80(11): 1241 - 1248. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Nagdyman, P. Ewert, K. Schmitt, M. Hubler, B. Stiller, C. Muller, and F. Berger Protein S-100 is present in extracerebral fluids before and after cardiac surgery in children Ann Clin Biochem, July 1, 2008; 45(4): 409 - 412. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. F. Laterza, V. R. Modur, D. L. Crimmins, J. V. Olander, Y. Landt, J.-M. Lee, and J. H. Ladenson Identification of Novel Brain Biomarkers Clin. Chem., September 1, 2006; 52(9): 1713 - 1721. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Carrier, A. Denault, J. Lavoie, and L. P. Perrault Randomized controlled trial of pericardial blood processing with a cell-saving device on neurologic markers in elderly patients undergoing coronary artery bypass graft surgery. Ann. Thorac. Surg., July 1, 2006; 82(1): 51 - 55. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. C. Lases, M. A. Schepens, F. J. Haas, L. P. Aarts, H. T. ter Beek, E. P. van Dongen, H. P. Siegers, I. van der Tweel, and E. H. Boezeman Clinical prospective study of biochemical markers and evoked potentials for identifying adverse neurological outcome after thoracic and thoracoabdominal aortic aneurysm surgery Br. J. Anaesth., November 1, 2005; 95(5): 651 - 661. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Watson, S. M. Shirreffs, and R. J. Maughan Blood-brain barrier integrity may be threatened by exercise in a warm environment Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1689 - R1694. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Svenmarker, K G Engstrom, T Karlsson, E Jansson, R Lindholm, and T Aberg Influence of pericardial suction blood retransfusion on memory function and release of protein S100B Perfusion, December 1, 2004; 19(6): 337 - 343. [Abstract] [PDF]
|
|
|
|
 |
|
 T. Sakamoto, D. Zurakowski, L. F. Duebener, H. G. W. Lidov, G. L. Holmes, R. J. Hurley, P. C. Laussen, and R. A. Jonas Interaction of temperature with hematocrit level and pH determines safe duration of hypothermic circulatory arrest J. Thorac. Cardiovasc. Surg., August 1, 2004; 128(2): 220 - 232. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Motallebzadeh, R. Kanagasabay, M. Bland, J. C. Kaski, and M. Jahangiri S100 protein and its relation to cerebral microemboli in on-pump and off-pump coronary artery bypass surgery Eur. J. Cardiothorac. Surg., March 1, 2004; 25(3): 409 - 414. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tiainen, R. O. Roine, V. Pettila, and O. Takkunen Serum Neuron-Specific Enolase and S-100B Protein in Cardiac Arrest Patients Treated With Hypothermia Stroke, December 1, 2003; 34(12): 2881 - 2886. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. E. Pelinka, L. Szalay, M. Jafarmadar, R. Schmidhammer, H. Redl, and S. Bahrami Circulating S100B is increased after bilateral femur fracture without brain injury in the rat Br. J. Anaesth., October 1, 2003; 91(4): 595 - 597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ueno, Y. Iguro, H. Yamamoto, R. Sakata, Y. Kakihana, and K. Nakamura Serial measurement of serum S-100B protein as a marker of cerebral damage after cardiac surgery Ann. Thorac. Surg., June 1, 2003; 75(6): 1892 - 1897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Vaage and R. Anderson Biochemical markers of neurologic injury in cardiac surgery: The rise and fall of S100{beta} J. Thorac. Cardiovasc. Surg., March 1, 2003; 125(90030): S31 - 33. [Full Text] [PDF]
|
|
|
|
|
|
M de Baar, J C Diephuis, K G M Moons, J Holtkamp, R Hijman, and C J Kalkman The effect of zero-balanced ultrafiltration during cardiopulmonary bypass on S100b release and cognitive function Perfusion, January 1, 2003; 18(1): 9 - 14. [Abstract] [PDF]
|
|
|
|
|
|
P. Johnsson, M. Backstrom, C. Bergh, H. Jonsson, C. Luhrs, and C. Alling Increased S100B in blood after cardiac surgery is a powerful predictor of late mortality Ann. Thorac. Surg., January 1, 2003; 75(1): 162 - 168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Fromes, D. Gaillard, O. Ponzio, M. Chauffert, M.-F. Gerhardt, P. Deleuze, and O. M. Bical Reduction of the inflammatory response following coronary bypass grafting with total minimal extracorporeal circulation Eur. J. Cardiothorac. Surg., October 1, 2002; 22(4): 527 - 533. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. I Flom-Halvorsen, E Ovrum, F Brosstad, G Tangen, M A. Ringdal, and R Oystese Effects of two differently heparin-coated extracorporeal circuits on markers for brain and myocardial dysfunction Perfusion, September 1, 2002; 17(5): 339 - 345. [Abstract] [PDF]
|
|
|
|
|
|
G. S. Aldea, L. O. Soltow, W. L. Chandler, C. M. Triggs, C. R. Vocelka, G. I. Crockett, Y. T. Shin, W. E. Curtis, and E. D. Verrier Limitation of thrombin generation, platelet activation, and inflammation by elimination of cardiotomy suction in patients undergoing coronary artery bypass grafting treated with heparin-bonded circuits J. Thorac. Cardiovasc. Surg., April 1, 2002; 123(4): 742 - 755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L Zarro, D. A Palanzo, and R. M Montesano A comparison of several variables of off-pump coronary artery bypass procedures versus myocardial revascularization utilizing cardiopulmonary bypass Perfusion, January 1, 2002; 17(1): 9 - 14. [Abstract] [PDF]
|
|
|
|
|
|
J. Vaage and R. Anderson Biochemical markers of neurologic injury in cardiac surgery: The rise and fall of S100{beta} J. Thorac. Cardiovasc. Surg., November 1, 2001; 122(5): 853 - 855. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
