HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Henrik Jönsson Per Johnsson Stephen Westaby Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Jönsson, H. Articles by Blomquist, S. Search for Related Content PubMed PubMed Citation Articles by Jönsson, H. Articles by Blomquist, S. Related Collections Cerebral protection

Ann Thorac Surg 2001;71:1433-1437
© 2001 The Society of Thoracic Surgeons

---

Original article: cardiovascular

S100B as a predictor of size and outcome of stroke after cardiac surgery

^a Department of Cardiothoracic Surgery, University of Lund, Lund, Sweden
^b Oxford Heart Centre, Oxford, United Kingdom

Accepted for publication November 3, 2000.

Address reprint requests to Dr Jönsson, Department of Cardiothoracic Surgery, University Hospital Lund, SE-221 85 Lund, Sweden
e-mail: henrik.jonsson{at}thorax.lu.se

Background. Stroke after cardiac surgery is a clinical problem with often fatal or disabling outcome. To assess severity and probable outcome in affected patients only from clinical and radiological examinations is difficult. The glial-derived protein S100B has been suggested to be a marker of cerebral ischemia, and increased blood concentrations of S100B have been shown to correlate with size of lesion and prognosis after stroke. We studied the validity of S100B as a predictor of size of brain lesion and median term outcome in a consecutive group of patients suffering from stroke after cardiac surgery.

Methods. During a period of 17 months, 20 patients with clinical signs of postoperative stroke were investigated with S100B measurement, sampled at 5, 15 and 48 hours after surgery. All patients were examined with computed tomography or magnetic resonance imaging to confirm the diagnosis, and the size of cerebral infarction was estimated from the radiological examinations. The patients were followed up for survival 24 to 39 months after surgery.

Results. S100B concentration in blood 48 hours after surgery correlated with the size of infarcted brain tissue (r = 0.68, p < 0.001). Nine patients had S100B levels exceeding 0.5 µg/L and a 2-year mortality of 78%, whereas the 11 patients with S100B below 0.5 µg/L had a mortality of 18%.

Conclusions. Increased S100B in patients with a stroke following cardiac surgery correlate with the size of infarcted brain tissue. High S100B levels 48 hours after surgery have a negative predictive value for median term survival.

This article has been cited by other articles:

				E. C. Lases, M. A. Schepens, F. J. Haas, L. P. Aarts, H. T. ter Beek, E. P. van Dongen, H. P. Siegers, I. van der Tweel, and E. H. Boezeman Clinical prospective study of biochemical markers and evoked potentials for identifying adverse neurological outcome after thoracic and thoracoabdominal aortic aneurysm surgery Br. J. Anaesth., November 1, 2005; 95(5): 651 - 661. [Abstract] [Full Text] [PDF]

				V. Fazio, S. K. Bhudia, N. Marchi, B. Aumayr, and D. Janigro Peripheral detection of S100{beta} during cardiothoracic surgery: what are we really measuring? Ann. Thorac. Surg., July 1, 2004; 78(1): 46 - 52. [Abstract] [Full Text] [PDF]

				R. Motallebzadeh, R. Kanagasabay, M. Bland, J. C. Kaski, and M. Jahangiri S100 protein and its relation to cerebral microemboli in on-pump and off-pump coronary artery bypass surgery Eur. J. Cardiothorac. Surg., March 1, 2004; 25(3): 409 - 414. [Abstract] [Full Text] [PDF]

				M. Tiainen, R. O. Roine, V. Pettila, and O. Takkunen Serum Neuron-Specific Enolase and S-100B Protein in Cardiac Arrest Patients Treated With Hypothermia Stroke, December 1, 2003; 34(12): 2881 - 2886. [Abstract] [Full Text] [PDF]

				P. Johnsson, M. Backstrom, C. Bergh, H. Jonsson, C. Luhrs, and C. Alling Increased S100B in blood after cardiac surgery is a powerful predictor of late mortality Ann. Thorac. Surg., January 1, 2003; 75(1): 162 - 168. [Abstract] [Full Text] [PDF]

				Y. Fromes, D. Gaillard, O. Ponzio, M. Chauffert, M.-F. Gerhardt, P. Deleuze, and O. M. Bical Reduction of the inflammatory response following coronary bypass grafting with total minimal extracorporeal circulation Eur. J. Cardiothorac. Surg., October 1, 2002; 22(4): 527 - 533. [Abstract] [Full Text] [PDF]

				H. I Flom-Halvorsen, E Ovrum, F Brosstad, G Tangen, M A. Ringdal, and R Oystese Effects of two differently heparin-coated extracorporeal circuits on markers for brain and myocardial dysfunction Perfusion, September 1, 2002; 17(5): 339 - 345. [Abstract] [PDF]

				G. S. Aldea, L. O. Soltow, W. L. Chandler, C. M. Triggs, C. R. Vocelka, G. I. Crockett, Y. T. Shin, W. E. Curtis, and E. D. Verrier Limitation of thrombin generation, platelet activation, and inflammation by elimination of cardiotomy suction in patients undergoing coronary artery bypass grafting treated with heparin-bonded circuits J. Thorac. Cardiovasc. Surg., April 1, 2002; 123(4): 742 - 755. [Abstract] [Full Text] [PDF]