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Ann Thorac Surg 2001;71:995-1002
© 2001 The Society of Thoracic Surgeons

Original article: general thoracic

Economic analysis of lung volume reduction surgery as part of the national emphysema treatment trial

Scott D. Ramsey, MDa, Sean D. Sullivan, PhDb, Robert M. Kaplan, PhDe, Douglas E. Wood, MDc, Yen-Pin Chiang, PhDd, Judith L. Wagner, PhDf, for the NETT Research Group

a Department of Medicine, University of Washington, Seattle, Washington, USA
b Department of Pharmacy, University of Washington, Seattle, Washington, USA
c Department of Surgery, University of Washington, Seattle, Washington, USA
d Center for Outcomes & Effectiveness Research, Agency for Healthcare Research and Quality, Rockville, Maryland, USA
e Department of Family & Preventive Medicine, University of California, San Diego, California, USA
f Health & Human Resources Division, Congressional Budget Office, Washington, DC, USA

Accepted for publication August 11, 2000.

Address reprint requests to Dr Ramsey, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Mailstop MP-900, Seattle, WA 98109
e-mail: sramsey{at}fhcrc.org

Background. In today’s cost-conscious health care environment, obtaining timely and accurate economic information regarding new medical technologies has become extremely important. The National Emphysema Treatment Trial, a multicenter, randomized controlled trial of lung volume reduction surgery (LVRS) plus medical therapy, versus medical therapy for patients with severe emphysema, includes a parallel cost-effectiveness analysis.

Methods. The analysis is designed to determine the cost-effectiveness of LVRS versus medical therapy for those who are eligible for the procedure. After describing theoretical foundations of cost-effectiveness analysis as they apply to this study, we describe the economic and quality of life data that are being collected alongside the clinical trial, methods of analysis, and approach to presenting the results.

Results. The cost-effectiveness of LVRS relative to medical therapy will be presented as costs per quality-adjusted life years gained.

Conclusions. This analysis will provide timely economic data that can be considered alongside the clinical results of the National Emphysema Treatment Trial. As one of the largest clinical trials to include a parallel, prospective cost-effectiveness analyses, this study will also provide valuable practical information about conducting an economic analysis alongside a multicenter clinical trial.




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