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Ann Thorac Surg 2001;71:949-954
© 2001 The Society of Thoracic Surgeons

Original article: general thoracic

E-cadherin expression associated with differentiation and prognosis in patients with non–small cell lung cancer

Dage Liu, MDa, Cheng-long Huang, MDa, Kotaro Kameyama, MDa, Eiichi Hayashi, MDa, Akira Yamauchi, MDa, Shoji Kobayashi, MDb, Hiroyasu Yokomise, MDa

a Second Department of Surgery, Kagawa Medical University, Kagawa, Japan
b Department of Pathology, Kagawa Medical University, Kagawa, Japan

Accepted for publication October 18, 2000.

Address reprint request to Dr Yokomise, Second Department of Surgery, Kagawa Medical University, 1750-1, Miki-cho, Kita-gun, Kagawa 761-0793, Japan
e-mail: yokomise{at}kms.ac.jp

Background. E-Cadherin plays a major role in maintaining the intercellular junctions in epithelial tissues. The reduction of E-cadherin expression in cancer cells may be associated with tumor differentiation, metastasis, and a poor prognosis.

Methods. Immunohistochemistry for E-cadherin expression was performed on 109 tumors from patients with non–small cell lung cancer who underwent operations.

Results. With respect to membranous immunostaining, 57 carcinomas were E-cadherin-positive, 39 carcinomas E-cadherin-reduced, and 13 carcinomas E-cadherin-negative. The percentage of poorly differentiated tumors in the impaired E-cadherin expression group was significantly higher than that in the E-cadherin-positive group (p = 0.005). Furthermore, the frequency of lymph node metastases in tumors with impaired E-cadherin expression was significantly higher than that in the E-cadherin-positive tumors (p = 0.011). A Cox regression analysis revealed that E-cadherin expression was a significant factor in the prediction of survival for patients with non–small cell lung cancer (p = 0.002).

Conclusions. E-Cadherin expression was associated with tumor differentiation, lymph node metastasis, and prognosis in patients with non–small cell lung cancer.




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