| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 2001;71:823-826
© 2001 The Society of Thoracic Surgeons
a Unit of Health Psychology, Department of Psychiatry and Behavioural Sciences, London, England, United Kingdom
b Centre for Cardiovascular Genetics, Department of Medicine, London, England, United Kingdom
c Neurological Studies, University College London, London, England, United Kingdom
Accepted for publication October 18, 2000.
Address reprint requests to Prof Newman, Unit of Health Psychology, Department of Psychiatry, RF & UCL Medical School, Wolfson Bld, 48 Riding House St, London, W1N 8AA, England
e-mail: s.newman{at}ucl.ac.uk
Background. Recently, Tardiff and colleagues have suggested that the presence of the apolipoprotein E, 
4 allele was associated with increased likelihood of cognitive decline after coronary artery bypass grafting. The objective of the current study was to replicate this earlier work using an increased sample size. The increased sample also enabled an analysis by individual genotype in cognitive decline after coronary artery bypass grafting.
Methods. Apolipoprotein E genotyping was performed on 111 individuals undergoing coronary artery bypass grafting. Each participant underwent a battery of nine neuropsychological tests before operation and 4 to 7 weeks after operation.
Results. Cognitive decline, assessed by both continuous Z change scores and two categoric measures of cognitive deficit, was not significantly associated with either individual apolipoprotein E genotypes or categorization by the presence or absence of the 4 allele. The examination of potential moderating factors did not alter this finding.
Conclusions. This study suggests that the 4 allele is not associated with cognitive decline in the weeks after coronary artery bypass grafting.
This article has been cited by other articles:
|
|
 |
|
  I. Zeltser, G. P. Jarvik, J. Bernbaum, G. Wernovsky, A. S. Nord, M. Gerdes, E. Zackai, R. Clancy, S. C. Nicolson, T. L. Spray, et al. Genetic factors are important determinants of neurodevelopmental outcome after repair of tetralogy of Fallot J. Thorac. Cardiovasc. Surg., January 1, 2008; 135(1): 91 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. A. Selnes, M. A. Grega, M. M. Bailey, L. Pham, S. Zeger, W. A. Baumgartner, and G. M. McKhann Neurocognitive Outcomes 3 Years After Coronary Artery Bypass Graft Surgery: A Controlled Study Ann. Thorac. Surg., December 1, 2007; 84(6): 1885 - 1896. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. I. Tagarakis, F. Tsolaki-Tagaraki, M. Tsolaki, A. Diegeler, N. B. Tsilimingas, and A. Papassotiropoulos The Role of Apolipoprotein E in Cognitive Decline and Delirium after Bypass Heart Operations American Journal of Alzheimer's Disease and Other Dementias, July 1, 2007; 22(3): 223 - 228. [Abstract] [PDF]
|
|
|
|
 |
|
 D.C. Whitaker, A.J.E. Green, J. Stygall, M.J.G. Harrison, and S.P. Newman Evaluation of an alternative S100b assay for use in cardiac surgery: relationship with microemboli and neuropsychological outcome. Perfusion, July 1, 2007; 22(4): 267 - 272. [Abstract] [PDF]
|
|
|
|
 |
|
 W. A. Kofke, P. A. Blissitt, H. Rao, J. Wang, K. Addya, and J. Detre Remifentanil-Induced Cerebral Blood Flow Effects in Normal Humans: Dose and ApoE Genotype Anesth. Analg., July 1, 2007; 105(1): 167 - 175. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. P. Grocott Genetic influences on cerebral outcome after cardiac surgery. Seminars in Cardiothoracic and Vascular Anesthesia, December 1, 2006; 10(4): 291 - 296. [Abstract] [PDF]
|
|
|
|
 |
|
 E. J. Heyer, D. A. Wilson, D. H. Sahlein, J. Mocco, S. C. Williams, R. Sciacca, A. Rampersad, R. J. Komotar, J. Zurica, A. Benvenisty, et al. APOE-{varepsilon}4 predisposes to cognitive dysfunction following uncomplicated carotid endarterectomy Neurology, December 13, 2005; 65(11): 1759 - 1763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Gaynor, M. Gerdes, E. H. Zackai, J. Bernbaum, G. Wernovsky, R. R. Clancy, M. F. Newman, A. M. Saunders, P. J. Heagerty, J. A. D'Agostino, et al. Apolipoprotein E genotype and neurodevelopmental sequelae of infant cardiac surgery J. Thorac. Cardiovasc. Surg., December 1, 2003; 126(6): 1736 - 1745. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Whitaker The use of Z scores in assessing neuropsychological change after cardiac operations Ann. Thorac. Surg., March 1, 2003; 75(3): 1066 - 1066. [Full Text] [PDF]
|
|
|
|
|
|
A. Collie, D. G. Darby, P. Maruff, and B. S. Silbert The use of Z scores in assessing neuropsychological change after cardiac operations: Reply Ann. Thorac. Surg., March 1, 2003; 75(3): 1066 - 1067. [Full Text] [PDF]
|
|
|
|
 |
|
 M J A Robson, R P Alston, P J D Andrews, P R Wenham, M J Souter, and I J Deary Apolipoprotein E and neurocognitive outcome from coronary artery surgery J. Neurol. Neurosurg. Psychiatry, May 1, 2002; 72(5): 675 - 676. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
