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Ann Thorac Surg 2001;71:1004-1006
© 2001 The Society of Thoracic Surgeons

Case report

Aerosolized iloprost for severe pulmonary hypertension as a bridge to heart transplantation

Thorsten Wittwer, MDa, Klaus Pethig, MDa, Martin Strüber, MDa, Marius Hoeper, MDb, Wolfgang Harringer, MDa, Axel Haverich, MDa, Ulrich Franke, MDa, Thorsten Wahlers, MDa

a Departments of Thoracic and Cardiovascular Surgery, Medical School Hannover, Hannover, Germany
b Pulmonary Medicine, Medical School Hannover, Hannover, Germany

Accepted for publication March 21, 2000.

Address reprint requests to Dr Wittwer, Department of Cardiothoracic and Vascular Surgery, Friedrich-Schiller University, 07740 Jena, Germany
e-mail: th.wittwer-md{at}t-online.de

Preexisting pulmonary hypertension in pediatric patients is associated with poor outcome after cardiac transplantation because of donor right ventricular dysfunction. To avoid a combined heart-lung transplantation in a 17-year-old patient, we used an intensified pretreatment with intravenous prostacyclin and dobutamine combined with an inhalative therapy with the aerosolized prostacyclin-analog Iloprost. With this regimen, the patient was hemodynamically stabilized for the waiting period of 21 days after which an uneventful cardiac transplantation was performed.




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S. E Baker and R. H. Hockman
Inhaled Iloprost in Pulmonary Arterial Hypertension
Ann. Pharmacother., July 1, 2005; 39(7): 1265 - 1274.
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A. Sablotzki, T. Hentschel, E. Gruenig, S. Schubert, I. Friedrich, J. Muhling, M. G. Dehne, and E. Czeslick
Hemodynamic effects of inhaled aerosolized iloprost and inhaled nitric oxide in heart transplant candidates with elevated pulmonary vascular resistance
Eur. J. Cardiothorac. Surg., November 1, 2002; 22(5): 746 - 752.
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