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Ann Thorac Surg 2001;71:667-672
© 2001 The Society of Thoracic Surgeons

Original article: cardiovascular

Is there a relationship between cognitive dysfunction and systemic inflammatory response after cardiopulmonary bypass?

Stephen Westaby, FRCSa, Kjell Saatvedt, MD, PhDa, Samantha White, MAa, Takahiro Katsumata, MD, PhDa, Willem van Oeveren, PhDb, Peter W. Halligan, PhDc

a Oxford Heart Centre, John Radcliffe Hospital, Oxford, England, UK
b University of Groningen, Groningen, The Netherlands
c Department of Psychology, Cardiff University, Cardiff, Wales, UK

Accepted for publication September 9, 2000.

Address reprint requests to Dr Westaby, Oxford Heart Centre, John Radcliffe Hospital, Oxford OX3 9DU, England
e-mail: swestaby{at}ahf.org.uk

Background. The systemic inflammatory reaction (SIR) is assumed to be one of the factors that causes cerebral dysfunction after cardiopulmonary bypass (CPB). The aim of the present study was to evaluate the relationship between the SIR and postoperative cognitive performance at 5 days and 3 months.

Methods. One hundred patients undergoing coronary artery bypass grafting were studied. Inflammatory markers and markers of coagulation and fibrinolysis were determined at several time points during and after the operation. Correlation analysis between maximum levels of the different markers and early and late performance was performed.

Results. No overall association was found between the maximum levels of the inflammatory markers and early and late function.

Conclusions. Notwithstanding limitations of statistical power established markers of systemic inflammatory reaction showed no relationship with outcome at 5-day or 3-month follow-up in this subset of patients.




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