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Right arrow Congenital - cyanotic

Ann Thorac Surg 2001;71:494-500
© 2001 The Society of Thoracic Surgeons

Original article: cardiovascular

Outcome after repair of tetralogy of Fallot in the first year of life

Christos Alexiou, FRCSa, Hyam Mahmoud, MRCPCHb, Ahmed Al-Khaddour, MDa, James Gnanapragasam, FRCPb, Anthony P. Salmon, FRCPb, Barry R. Keeton, FRCPb, James L. Monro, FRCSa

a Department of Cardiac Surgery, The General Hospital, Southampton, United Kingdom
b Department of Paediatric Cardiology, The General Hospital, Southampton, United Kingdom

Accepted for publication September 25, 2000.

Address reprint requests to Dr Monro, Department of Cardiac Surgery, The General Hospital, Tremona Rd, Southampton SO16 6YD, UK
e-mail: monro1711{at}aol.com

Background. The purpose of this study was to evaluate the early and late outcome after repair of tetralogy of Fallot in the first year of life.

Methods. Between 1974 and 2000, 89 consecutive infants with a mean age of 6.3 ± 2.6 months (range, 15 days to 12 months) underwent repair of tetralogy of Fallot (ventricular septal defect and pulmonary stenosis) by one surgeon (J.L.M.). Three infants had previous palliative operations. Sixty-seven procedures were urgent or emergency. A transannular patch was inserted in 69 patients (77.5%). Follow-up was complete, averaging 13.4 ± 5.6 years (range, 0 to 25.4 years).

Results. There was one operative death (1.1%). Mean right ventricular to left ventricular pressure ratio postoperatively was 0.4 ± 1.1 (in 79 patients, < 0.5). Fourteen patients underwent reoperations or reinterventions. There were no reoperations for residual or recurrent ventricular septal defect. Kaplan-Meier freedom from reoperation or reintervention for any cause at 20 years was 85% ± 4.4%, for relief of right ventricular outflow tract obstruction it was 94% ± 3.1%, and for pulmonary valve replacement this was 95.4% ± 2.6%. Use of a transannular patch did not significantly affect the need for reoperation or reintervention. There was one late death (leukemia). Kaplan-Meier 20-year survival was 97.8% ± 1.9%. On latest echocardiography, 42 patients had moderate pulmonary regurgitation, 4 had a right ventricular outflow tract gradient more than 40 mm Hg, and 86 had good biventricular function. Twelve-lead electrocardiography was performed in all and 24-hour electrocardiography in 61 patients. One patient (1.1%) exhibited late recurrent ventricular tachycardia requiring implantation of a defibrillator. The remaining 86 patients are in New York Heart Association class I with none of them receiving antiarrhythmic medications.

Conclusions. These data strongly support the concept of early repair of tetralogy of Fallot. It is associated with an acceptable operative risk and a low incidence of significant arrhythmias, and provides long-term survival similar to that observed in the general population. Late complications may, however, develop, and long-term follow-up for their early recognition is essential.




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