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Ann Thorac Surg 2000;70:2113-2118
© 2000 The Society of Thoracic Surgeons

Original article: cardiovascular

Efficacy of intracoronary versus intravenous FGF-2 in a pig model of chronic myocardial ischemia

Kaori Sato, MDa,b, Roger J. Laham, MDa,b, Justin D. Pearlman, MD, PhDa,b, Deborah Novicki, PhDa,b, Frank W. Sellke, MDa,b, Michael Simons, MDa,b, Mark J. Post, MD, PhDa,b

a Angiogenesis Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
b Chiron Corporation, Emeryville, California, USA

Address reprint requests to Dr Post, Angiogenesis Research Center, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215
e-mail: mpost{at}caregroup.harvard.edu

Presented at the Poster Session of the Thirty-sixth Annual Meeting of The Society of Thoracic Surgeons, Fort Lauderdale, FL, Jan 31–Feb 2, 2000.

Background. Therapeutic angiogenesis in ischemic myocardium has been shown to be a feasible and effective strategy to improve regional blood flow and myocardial function. However, the optimal mode of growth factor administration still needs to be established.

Methods. Using a pig model of chronic myocardial ischemia, we evaluated the efficacy of intravenous and intracoronary infusion of FGF-2 at 2 and 6 µg/kg compared with a vehicle control. Improvement in myocardial perfusion and function was assessed by angiography, colored microspheres, and function and perfusion magnetic resonance imaging.

Results. Intracoronary 6-µg/kg FGF-2 increased angiographic collaterals (p = 0.046) and increased regional blood flow to the ischemic area from 0.36 ± 0.07 to 0.59 ± 0.08 mL/min/g at stress (vs control, p = 0.032). Also, after 6 µg/kg intracoronary FGF-2, ejection fraction, regional wall motion, and thickening improved significantly by 9.9% ± 1.9%, 126% ± 39%, and 13.8% ± 3.6%, respectively. Intravenous FGF-2 and intracoronary 2 µg/kg FGF-2 were ineffective.

Conclusions. A single 6-µg/kg intracoronary treatment with FGF-2 resulted in significant improvement in collateralization and regional and global function of chronically ischemic myocardium. Single intravenous infusion of FGF-2 was not effective in this model.


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Ann. Thorac. Surg. 2000 70: 2118. [Extract] [Full Text] [PDF]



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