| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 2000;70:2054-2063
© 2000 The Society of Thoracic Surgeons
a Department of Cardiothoracic Surgery, National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, Heart Science Centre, Harefield Hospital, Uxbridge, United Kingdom
b Department of Histochemistry, Imperial College School of Medicine, London, United Kingdom
Accepted for publication May 1, 2000.
Address reprint requests to Professor Yacoub, Department of Cardiothoracic Surgery, National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, Heart Science Centre, Harefield Hospital, Hill End Road, Uxbridge, United Kingdom
Background. The potential role of the local renin-angiotensin system to differentially affect radial artery and internal thoracic artery graft performance has not been examined.
Methods. Contractile responses to angiotensin I and II in the radial artery and the internal thoracic artery were examined in vitro. The expression function, and localization of angiotensin receptors, angiotensin converting enzyme, and chymase were studied in radial artery and internal thoracic artery segments.
Results. Angiotensin I and II contractions were significantly greater (p < 0.05) in the radial artery compared to the internal thoracic artery. In both arteries, angiotensin II responses were mediated via the AT1 receptor. Messenger RNA transcripts for angiotensin-converting enzyme and chymase were detected in both arteries. Angiotensin-converting enzyme was localized to luminal and vaso vasorum endothelial cells and smooth muscle cells in both vessels, while chymase was colocalized with mast cells in adventitial and medial layers. An angiotensin converting enzyme or a chymase inhibitor singularly had no effect on angiotensin I contractions, however, when combined, a marked inhibition of the angiotensin I response was observed in both vessels.
Conclusions. Our results illustrate the complexities which exist within the local renin angiotensin system and suggest that clinical trials which may modulate the system are warranted.
This article has been cited by other articles:
|
|
 |
|
  M. J. Shackcloth, A. R. Conant, J. Thekkudan, S. Ghotkar, A. W.M. Simpson, and W. C. Dihmis Attenuation of receptor-dependent and -independent vasoconstriction in the human radial artery Eur. J. Cardiothorac. Surg., October 1, 2008; 34(4): 839 - 844. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Attaran, L. John, and A. El-Gamel Clinical and Potential Use of Pharmacological Agents to Reduce Radial Artery Spasm in Coronary Artery Surgery Ann. Thorac. Surg., April 1, 2008; 85(4): 1483 - 1489. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A Doggrell and J. C Wanstall Vascular chymase: pathophysiological role and therapeutic potential of inhibition Cardiovasc Res, March 1, 2004; 61(4): 653 - 662. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Mangoush, K. Nakamura, S. Al-Ruzzeh, T. Athanasiou, A. Chester, and M. Amrani Effect of ascorbic acid on endothelium-dependent vasodilatation of human arterial conduits for coronary artery bypass grafting Eur. J. Cardiothorac. Surg., October 1, 2003; 24(4): 541 - 546. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nakamura, S. Al-Ruzzeh, A. H. Chester, I. Schmidt, M. Barbir, M. H. Yacoub, and M. Amrani Effects of cerivastatin on vascular function of human radial and left internal thoracic arteries Ann. Thorac. Surg., June 1, 2002; 73(6): 1860 - 1865. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
