ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Lawrence J. Dacey
Edward R. Johnson
Bruce J. Leavitt
Christopher T. Maloney
Jeremy R. Morton
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dacey, L. J.
Right arrow Articles by O’Connor, G. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dacey, L. J.
Right arrow Articles by O’Connor, G. T.

Ann Thorac Surg 2000;70:1986-1990
© 2000 The Society of Thoracic Surgeons

Original article: cardiovascular

Effect of preoperative aspirin use on mortality in coronary artery bypass grafting patients

Lawrence J. Dacey, MDa, John J. Munoz, MDa, Edward R. Johnson, MDb, Bruce J. Leavitt, MDc, Christopher T. Maloney, MDd, Jeremy R. Morton, MDe, Elaine M. Olmstead, BAf, John D. Birkmeyer, MDa,f,g, Gerald T. O’Connor, PhD, DScf,g,h, for the Northern New England Cardiovascular Disease Study Group

a Department of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA
b Department of Surgery, Eastern Maine Medical Center, Bangor, Maine, USA
c Department of Surgery, Fletcher-Allen Health Care, Burlington, Vermont, USA
d Department of Surgery, Catholic Medical Center, Manchester, New Hampshire, USA
e Department of Surgery, Maine Medical Center, Portland, Maine, USA
f Center for the Evaluative Clinical Sciences, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA
g Community & Family Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA
h Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA

Accepted for publication May 23, 2000.

Address reprint requests to Dr Dacey, Cardiothoracic Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756-0001
e-mail: lawrence.j.dacey{at}dartmouth.edu

Background. Discontinuing aspirin use in patients before coronary artery bypass grafting (CABG) has focused on bleeding risks. The effect of aspirin use on overall mortality with this procedure has not been studied.

Methods. We performed a case patient–control patient study of the 8,641 consecutive isolated CABG procedures performed between July 1987 and May 1991 in Maine, New Hampshire, and Vermont. Patients included all 368 deaths. Each case patient was paired with approximately two matched survivors (control patients). Aspirin use was defined by identification of ingestion within 7 days before the operation.

Results. CABG patients using preoperative aspirin were less likely to experience in-hospital mortality in univariate (odds ratio [OR] = 0.73, 95% confidence interval [0.54, 0.97]) and multivariate [OR = 0.55, (0.31, 0.98)] analysis compared to nonusers. No significant difference was seen in the amount of chest tube drainage, transfusion of blood products, or need for reexploration for hemorrhage between patients who did and did not receive aspirin.

Conclusions. Preoperative aspirin use appears to be associated with a decreased risk of mortality in CABG patients without significant increase in hemorrhage, blood product requirements, or related morbidities.




This article has been cited by other articles:


Home page
 Eur. J. Cardiothorac. Surg.Home page
G. Suwalski, P. Suwalski, K. J. Filipiak, M. Postula, F. Majstrak, and G. Opolski
The effect of off-pump coronary artery bypass grafting on platelet activation in patients on aspirin therapy until surgery day.
Eur. J. Cardiothorac. Surg., August 1, 2008; 34(2): 365 - 369.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
J. C.J. Sun, R. Whitlock, J. Cheng, J. W. Eikelboom, L. Thabane, M. A. Crowther, and K. H.T. Teoh
The effect of pre-operative aspirin on bleeding, transfusion, myocardial infarction, and mortality in coronary artery bypass surgery: a systematic review of randomized and observational studies
Eur. Heart J., April 2, 2008; 29(8): 1057 - 1071.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
A. Ouattara, H. Bouzguenda, Y. Le Manach, P. Leger, A. Mercadier, P. Leprince, N. Bonnet, G. Montalescot, B. Riou, and P. Coriat
Impact of aspirin with or without clopidogrel on postoperative bleeding and blood transfusion in coronary surgical patients treated prophylactically with a low-dose of aprotinin
Eur. Heart J., April 12, 2007; (2007) ehm049v1.
[Abstract] [Full Text] [PDF]

Home page
 J CARDIOVASC PHARMACOL THERHome page
C. M. Dyke, L. K. Jennings, G. Maier, C. Andreou, R. Daly, and M. R. Tamberella III
Preoperative Platelet Inhibition With Eptifibatide During Coronary Artery Bypass Grafting With Cardiopulmonary Bypass
Journal of Cardiovascular Pharmacology and Therapeutics, March 1, 2007; 12(1): 54 - 60.
[Abstract] [PDF]

Home page
 haematolHome page
G. Renda, R. Di Pillo, A. D'Alleva, A. Sciartilli, M. Zimarino, E. De Candia, R. Landolfi, G. Di Giammarco, A. Calafiore, and R. De Caterina
Surgical bleeding after pre-operative unfractionated heparin and low molecular weight heparin for coronary bypass surgery
Haematologica, March 1, 2007; 92(3): 366 - 373.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
G. G.L. Biondi-Zoccai, M. Lotrionte, P. Agostoni, A. Abbate, M. Fusaro, F. Burzotta, L. Testa, I. Sheiban, and G. Sangiorgi
A systematic review and meta-analysis on the hazards of discontinuing or not adhering to aspirin among 50 279 patients at risk for coronary artery disease
Eur. Heart J., November 2, 2006; 27(22): 2667 - 2674.
[Abstract] [Full Text] [PDF]

Home page
 Canadian J. AnesthesiaHome page
A. Vincentelli, B. Jude, and S. Belisle
Antithrombotic therapy in cardiac surgery: [Traitement antithrombotique en chirurgie cardiaque].
Can J Anesth, June 1, 2006; 53(6_suppl): S89 - S102.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
A. A. Bavry and A. M. Lincoff
Is Clopidogrel Cardiovascular Medicine's Double-Edged Sword?
Circulation, April 4, 2006; 113(13): 1638 - 1640.
[Full Text] [PDF]

Home page
 ICVTSHome page
F. Nurozler, T. Kutlu, G. Kucuk, and C. Okten
Impact of clopidogrel on postoperative blood loss after non-elective coronary bypass surgery
Interactive CardioVascular and Thoracic Surgery, December 1, 2005; 4(6): 546 - 549.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
J.-Y. Leong, R. A. Baker, P. J. Shah, V. K. Cherian, and J. L. Knight
Clopidogrel and Bleeding After Coronary Artery Bypass Graft Surgery
Ann. Thorac. Surg., September 1, 2005; 80(3): 928 - 933.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
K. A. Bybee, B. D. Powell, U. Valeti, A. G. Rosales, S. L. Kopecky, C. Mullany, and R. S. Wright
Preoperative Aspirin Therapy Is Associated With Improved Postoperative Outcomes in Patients Undergoing Coronary Artery Bypass Grafting
Circulation, August 30, 2005; 112(9_suppl): I-286 - I-292.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J. C.J. Sun, M. A. Crowther, T. E. Warkentin, A. Lamy, and K. H.T. Teoh
Should Aspirin Be Discontinued Before Coronary Artery Bypass Surgery?
Circulation, August 16, 2005; 112(7): e85 - e90.
[Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
C. P. Cannon, S. R. Mehta, and S. F. Aranki
Balancing the Benefit and Risk of Oral Antiplatelet Agents in Coronary Artery Bypass Surgery
Ann. Thorac. Surg., August 1, 2005; 80(2): 768 - 779.
[Abstract] [Full Text] [PDF]

Home page
 SEMIN CARDIOTHORAC VASC ANESTHHome page
W. C. Nugent
Building and Supporting Sustainable Improvement in Cardiac Surgery: The Northern New England Experience
Seminars in Cardiothoracic and Vascular Anesthesia, June 1, 2005; 9(2): 115 - 118.
[Abstract] [PDF]

Home page
 ChestHome page
R. Gerrah, A. Elami, A. Stamler, A. Smirnov, and Z. Stoeger
Preoperative Aspirin Administration Improves Oxygenation in Patients Undergoing Coronary Artery Bypass Grafting
Chest, May 1, 2005; 127(5): 1622 - 1626.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
V. A. Ferraris, S. P. Ferraris, D. J. Moliterno, P. Camp, J. M. Walenga, H. L. Messmore, W. P. Jeske, F. H. Edwards, D. Royston, D. M. Shahian, et al.
The Society of Thoracic Surgeons Practice Guideline Series: Aspirin and Other Antiplatelet Agents During Operative Coronary Revascularization (Executive Summary)
Ann. Thorac. Surg., April 1, 2005; 79(4): 1454 - 1461.
[Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
S. Karthik, A. D. Grayson, E. E. McCarron, D. M. Pullan, and M. J. Desmond
Reexploration for bleeding after coronary artery bypass surgery: risk factors, outcomes, and the effect of time delay
Ann. Thorac. Surg., August 1, 2004; 78(2): 527 - 534.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
H. Karabulut and C. Alhan
Reply to Raja
Eur. J. Cardiothorac. Surg., July 1, 2004; 26(1): 232 - 232.
[Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
K. Furukawa and H. Ohteki
Changes in platelet aggregation after suspension of aspirin therapy
J. Thorac. Cardiovasc. Surg., June 1, 2004; 127(6): 1814 - 1815.
[Full Text] [PDF]

Home page
 Asian Cardiovasc. Thorac. Ann.Home page
R. Gerrah and U. Izhar
Beneficial Effect of Aspirin on Renal Function Post-Cardiopulmonary Bypass
Asian Cardiovasc Thorac Ann, December 1, 2003; 11(4): 304 - 308.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
V. Vaccarino and C. G. Koch
Long-term benefits of coronary bypass surgery: Are the gains for women less than for men?
J. Thorac. Cardiovasc. Surg., December 1, 2003; 126(6): 1707 - 1711.
[Full Text] [PDF]

Home page
 StrokeHome page
S. M. Dorhout Mees, G. J.E. Rinkel, J. W. Hop, A. Algra, and J. van Gijn
Antiplatelet Therapy in Aneurysmal Subarachnoid Hemorrhage: A Systematic Review
Stroke, September 1, 2003; 34(9): 2285 - 2289.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
A. K. Srinivasan, A. D. Grayson, D. M. Pullan, B. M. Fabri, and W. C. Dihmis
Effect of preoperative aspirin use in off-pump coronary artery bypass operations
Ann. Thorac. Surg., July 1, 2003; 76(1): 41 - 45.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
E. Akowuah, V. Shrivastava, and G. Cooper
Coronary artery bypass graft surgery in patients with recent exposure to clopidogrel and aspirin therapy
J. Am. Coll. Cardiol., April 16, 2003; 41(8): 1425 - 1426.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
R. H. Hongo, J. Ley, S. E. Dick, and R. R. Yee
The effect of clopidogrel incombination with aspirin whengiven before coronary artery bypass grafting
J. Am. Coll. Cardiol., July 17, 2002; 40(2): 231 - 237.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
R. Ehlers, T. W. Felbinger, H. K. Eltzschig, L. A. Fleisher, and K. A. Eagle
Lowering Cardiac Risk in Noncardiac Surgery
N. Engl. J. Med., April 4, 2002; 346(14): 1096 - 1097.
[Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
J. Hayat and W. C. Dihmis
Preoperative and immediate postoperative aspirin also reduces morbidity
Ann. Thorac. Surg., November 1, 2001; 72(5): 1797 - 1797.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2000 by The Society of Thoracic Surgeons.