HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Kazumasa Orihashi Yuichiro Matsuura Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Zhang, J.-M. Articles by Matsuura, Y. Search for Related Content PubMed PubMed Citation Articles by Zhang, J.-M. Articles by Matsuura, Y.

Ann Thorac Surg 2000;70:1601-1606
© 2000 The Society of Thoracic Surgeons

---

Original articles: cardiovascular

Cardioprotective effects of FK409, a nitric oxide donor, after isolated rat heart preservation for 16 hours

^a First Department of Surgery, Hiroshima University School of Medicine, Hiroshima, Japan

Address reprint requests to Dr Zhang, First Department of Surgery, Hiroshima University School of Medicine, Kasumi 1-2-3, Minami-ku, Hiroshima, 734-8551, Japan
e-mail: jiemin{at}mcai.med.hiroshima-u.ac.jp

Background. We examined the cardioprotective effects of FK409, a nitric oxide donor, after isolated rat heart preservation.

Methods. FK409 was administered to the hearts in pretreatment (FK409-1 group), during ischemia (FK409-2), or during reperfusion (FK409-3). The combined nitrate and nitrite level, coronary flow, cardiac function, coronary vasodilatory response, creatine kinase (CK), and myocardial water content were evaluated after the hearts had been preserved in University of Wisconsin solution at 0°C for 16 hours.

Results. The release of nitrate and nitrite increased in reperfusion between the 20-to-40-second measurement and the measurement at 40 minutes, and the recovery of cardiac function was significantly improved in the FK409 groups. The coronary vasodilatory response to acetylcholine chloride was enhanced in the FK409-1 and FK409-2 groups. CK release decreased in FK409 groups after 15 minutes in reperfusion.

Conclusions. This study suggests that FK409 has the best protective effect on cardiac function and coronary endothelial function when it is administered in the ischemic period, a less protective effect when administered during pretreatment, and the least protective effect when FK409 is given during reperfusion after heart preservation for 16 hours.

This article has been cited by other articles:

				K. G. Rajesh, S. Sasaguri, Z. Zhitian, R. Suzuki, R. Asakai, and H. Maeda Second window of ischemic preconditioning regulates mitochondrial permeability transition pore by enhancing Bcl-2 expression Cardiovasc Res, August 1, 2003; 59(2): 297 - 307. [Abstract] [Full Text] [PDF]