ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Online Discussion
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Gaetano Paone
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chaudhry, P. A.
Right arrow Articles by Sabbah, H. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chaudhry, P. A.
Right arrow Articles by Sabbah, H. N.

Ann Thorac Surg 2000;70:1275-1280
© 2000 The Society of Thoracic Surgeons

Original articles: cardiovascular

Passive epicardial containment prevents ventricular remodeling in heart failure

Pervaiz A. Chaudhry, MDb, Takayuki Mishima, MDa, Victor G. Sharov, MDa, James Hawkins, DVMa, Clif Alferness, BSa, Gaetano Paone, MDb, Hani N. Sabbah, PhDa

a Departments of Medicine, Henry Ford Heart and Vascular Institute, Henry Ford Health System, Detroit, Michigan, USA
b Surgery, Henry Ford Heart and Vascular Institute, Henry Ford Health System, Detroit, Michigan, USA

Address reprint requests to Dr Sabbah, Cardiovascular Research, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202
e-mail: hsabbah1{at}hfhs.org

Background. We examined the effects of passive containment of the cardiac ventricles with a surgically placed epicardial prosthetic wrap on indexes of left ventricular (LV) remodeling in dogs with heart failure.

Methods. Heart failure (LV ejection fraction 30% to 40%) was produced in 12 dogs by intracoronary microembolization. Six dogs underwent mid-sternotomy and pericardiotomy with placement of a preformed-knitted polyester device (Acorn Cardiac Support Device [CSD], Acorn Cardiovascular, Inc, St. Paul, MN) snugly around the ventricles and anchored to the atrioventricular groove. Six dogs did not undergo surgery and served as controls. Dogs were followed for 3 months prior to sacrifice.

Results. In controls, LV end-diastolic volume increased after 3 months (67 ± 12 versus 83 ± 8 ml; p = 0.04), while in CSD-treated dogs, it decreased (68 ± 10 versus 61 ± 10 ml; p = 0.002). CSD-containment of LV size was associated with increased LV systolic fractional area of shortening, while in controls, fractional area of shortening decreased. CSD-treated dogs also showed amelioration of myocyte hypertrophy and attenuation of interstitial fibrosis compared to controls.

Conclusions. In dogs with heart failure, passive epicardial containment of the ventricles with the Acorn CSD ameliorates LV remodeling and improves LV systolic function.




This article has been cited by other articles:


Home page
 Card Surg AdultHome page
J. I. Fann, N. B. Ingels Jr., and D. C. Miller
Pathophysiology of Mitral Valve Disease
Card. Surg. Adult, January 1, 2008; 3(2008): 973 - 1012.
[Full Text]

Home page
 Card Surg AdultHome page
M. T. Spoor and S. F. Bolling
Nontransplant Surgical Options for Heart Failure
Card. Surg. Adult, January 1, 2008; 3(2008): 1639 - 1648.
[Full Text]

Home page
 J Am Coll CardiolHome page
K. L. Fujimoto, K. Tobita, W. D. Merryman, J. Guan, N. Momoi, D. B. Stolz, M. S. Sacks, B. B. Keller, and W. R. Wagner
An Elastic, Biodegradable Cardiac Patch Induces Contractile Smooth Muscle and Improves Cardiac Remodeling and Function in Subacute Myocardial Infarction
J. Am. Coll. Cardiol., June 12, 2007; 49(23): 2292 - 2300.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
S. Christiansen and R. Autschbach
Doxorubicin in experimental and clinical heart failure.
Eur. J. Cardiothorac. Surg., October 1, 2006; 30(4): 611 - 616.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
K. L. Christman and R. J. Lee
Biomaterials for the Treatment of Myocardial Infarction
J. Am. Coll. Cardiol., September 5, 2006; 48(5): 907 - 913.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
M. A. Acker, S. Bolling, R. Shemin, J. Kirklin, J. K. Oh, D. L. Mann, M. Jessup, H. N. Sabbah, R. C. Starling, S. H. Kubo, et al.
Mitral valve surgery in heart failure: Insights from the Acorn Clinical Trial.
J. Thorac. Cardiovasc. Surg., September 1, 2006; 132(3): 568 - 577.e4.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
A. Cheng, T. C. Nguyen, M. Malinowski, F. Langer, D. Liang, G. T. Daughters, N. B. Ingels Jr, and D. C. Miller
Passive Ventricular Constraint Prevents Transmural Shear Strain Progression in Left Ventricle Remodeling
Circulation, July 4, 2006; 114(1_suppl): I-79 - I-86.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
P. Feindt, U. Boeken, J.D. Schipke, J. Litmathe, N. Zimmermann, and E. Gams
Ventricular constraint in dilated cardiomyopathy: A new, compliant textile mesh exerts prophylactic and therapeutic properties
J. Thorac. Cardiovasc. Surg., October 1, 2005; 130(4): 1107 - 1107.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
Y.-H. Kim, L. S.C. Czer, H. J. Soukiasian, M. De Robertis, K. E. Magliato, C. Blanche, S. S. Raissi, J. Mirocha, R. J. Siegel, R. M. Kass, et al.
Ischemic Mitral Regurgitation: Revascularization Alone Versus Revascularization and Mitral Valve Repair
Ann. Thorac. Surg., June 1, 2005; 79(6): 1895 - 1901.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
E. Monnet and J. C. Chachques
Animal Models of Heart Failure: What Is New?
Ann. Thorac. Surg., April 1, 2005; 79(4): 1445 - 1453.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
A. Lembcke, S. Dushe, S. Sonntag, C. Kloeters, C. N. H. Enzweiler, T. H. Wiese, B. Hamm, F.-X. Kleber, and W. F. Konertz
Changes in right ventricular dimensions and performance after passive cardiac containment
Ann. Thorac. Surg., September 1, 2004; 78(3): 900 - 905.
[Abstract] [Full Text] [PDF]

Home page
 ICVTSHome page
P. Feindt, U. Boeken, J. Litmathe, and E. Gams
Ventricular containment in the prophylaxis of experimental dilated cardiomyopathy
Interactive CardioVascular and Thoracic Surgery, December 1, 2003; 2(4): 575 - 580.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
H. N. Sabbah, V. G. Sharov, R. C. Gupta, S. Mishra, S. Rastogi, A. I. Undrovinas, P. A. Chaudhry, A. Todor, T. Mishima, E. J. Tanhehco, et al.
Reversal of Chronic Molecular and Cellular Abnormalities Due to Heart Failure by Passive Mechanical Ventricular Containment
Circ. Res., November 28, 2003; 93(11): 1095 - 1101.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
J. J. Pilla, A. S. Blom, D. J. Brockman, V. A. Ferrari, Q. Yuan, and M. A. Acker
Passive ventricular constraint to improve left ventricular function and mechanics in an ovine model of heart failure secondary to acute myocardial infarction
J. Thorac. Cardiovasc. Surg., November 1, 2003; 126(5): 1467 - 1475.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
M. C. Oz, W. F. Konertz, F. X. Kleber, F. W. Mohr, J. F. Gummert, J. Ostermeyer, M. Lass, J. Raman, M. A. Acker, and N. Smedira
Global surgical experience with the Acorn cardiac support device
J. Thorac. Cardiovasc. Surg., October 1, 2003; 126(4): 983 - 991.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
J. S. Raman, M. J. Byrne, J. M. Power, and C. A. Alferness
Ventricular constraint in severe heart failure halts decline in cardiovascular function associated with experimental dilated cardiomyopathy
Ann. Thorac. Surg., July 1, 2003; 76(1): 141 - 147.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
H. N. Sabbah
The cardiac support device and the Myosplint: treating heart failure by targeting left ventricular size and shape
Ann. Thorac. Surg., June 1, 2003; 75(90060): S13 - 19.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
A. Kashem, S. Hassan, D. L. Crabbe, D. B. Melvin, and W. P. Santamore
Left ventricular reshaping: Effects on the pressure-volume relationship
J. Thorac. Cardiovasc. Surg., February 1, 2003; 125(2): 391 - 399.
[Abstract] [Full Text] [PDF]

Home page
 Card Surg AdultHome page
V. Badhwar and S. F. Bolling
Nontransplant Surgical Options for Heart Failure
Card. Surg. Adult, January 1, 2003; 2(2003): 1515 - 1526.
[Full Text]

Home page
 CirculationHome page
J. J. Pilla, A. S. Blom, D. J. Brockman, F. Bowen, Q. Yuan, J. Giammarco, V. A. Ferrari, J. H. Gorman III, R. C. Gorman, and M. A. Acker
Ventricular Constraint Using the Acorn Cardiac Support Device Reduces Myocardial Akinetic Area in an Ovine Model of Acute Infarction
Circulation, September 24, 2002; 106(12_suppl_1): I-207 - I-211.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
W. F. Saavedra, R. S. Tunin, N. Paolocci, T. Mishima, G. Suzuki, C. W. Emala, P. A. Chaudhry, P. Anagnostopoulos, R. C. Gupta, H. N. Sabbah, et al.
Reverse remodeling and enhancedadrenergic reserve from passive externalsupport in experimental dilated heart failure
J. Am. Coll. Cardiol., June 19, 2002; 39(12): 2069 - 2076.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
W. F. Konertz, J. E. Shapland, H. Hotz, S. Dushe, J. P. Braun, K. Stantke, and F. X. Kleber
Passive Containment and Reverse Remodeling by a Novel Textile Cardiac Support Device
Circulation, September 18, 2001; 104(90001): I-270 - 275.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
A. Franco-Cereceda, P. M. McCarthy, E. H. Blackstone, K. J. Hoercher, J. A. White, J. B. Young, and R. C. Starling
Partial left ventriculectomy for dilated cardiomyopathy: Is this an alternative to transplantation?
J. Thorac. Cardiovasc. Surg., May 1, 2001; 121(5): 879 - 893.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2000 by The Society of Thoracic Surgeons.