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Ann Thorac Surg 2000;70:1185-1190
© 2000 The Society of Thoracic Surgeons

Original articles: general thoracic

Relevance of an intensive postoperative follow-up after surgery for non–small cell lung cancer

Virginie Westeel, MDa, Didier Choma, MDa, François Clément, MDb, Marie-Christine Woronoff-Lemsi, PhDc, Jean-François Pugin, MDa, André Dubiez, MDa, Alain Depierre, MDa

a Chest Disease Department, University Hospital, Besançon, France
b Department of Thoracic Surgery, University Hospital, Besançon, France
c Department of Pharmacy, University Hospital, Besançon, France

Address reprint requests to Dr Westeel, Service de pneumologie, CHU, Hôpital J Minjoz, Blvd Fleming, 25030 Besançon, France
e-mail: virginie.westeel{at}ufc-chu.univ-fcomte.fr

Background. Although a minimal follow-up with periodic clinic visits and chest radiographs is usually recommended after complete operation for non–small cell lung cancer, the ideal follow-up has not been defined yet. Objectives of this prospective study were to determine the feasibility of an intensive surveillance program and to analyze its influence on patient survival.

Methods. Follow-up consisted of physical examination and chest roentgenogram every 3 months and fiberoptic bronchoscopy and thoracic computed tomographic scan with sections of the liver and adrenal glands every 6 months. Influence of patient and recurrence characteristics on survival from recurrence was successively analyzed using the log-rank test and a Cox model adjusted for treatment.

Results. Among the 192 eligible patients, recurrence developed in 136 patients (71%) and was asymptomatic in 36 patients (26%). In 35 patients, recurrence was asymptomatic and detected by a scheduled procedure: thoracic computed tomographic scan in 10 (28%) patients and fiberoptic bronchoscopy in 10. Fifteen patients (43%) had a thoracic recurrence treated with curative intent. From the date of recurrence, 3-year survival was 13% in all patients and 31% in asymptomatic patients whose recurrence was detected by a scheduled procedure. Asymptomatic recurrences (p < 0.001), female sex (p < 0.001), performance status 2 or less (p = 0.01), and age 61 years or younger (p = 0.01) were shown to be significantly favorable prognostic factors.

Conclusions. This intensive follow-up is feasible and may improve survival by detecting recurrences after surgery for non–small cell lung cancer at an asymptomatic stage.




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