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Ann Thorac Surg 2000;70:824-828
© 2000 The Society of Thoracic Surgeons

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Original articles: cardiovascular

Basic fibroblast growth factor may improve devascularized sternal healing

^a Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
^b Institute for Frontier Medical Sciences, Kyoto, Japan
^c College of Medical Technology, Kyoto University, Kyoto, Japan

Address reprint requests to Dr Komeda, Department of Cardiovascular Surgery, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, Japan 606–8507
e-mail: masakom{at}kuhp.kyoto-u.ac.jp

Presented at the Thirty-sixth Annual Meeting of The Society of Thoracic Surgeons, Fort Lauderdale, FL, Jan 31–Feb 2, 2000.

Background. We have shown that a gelatin sheet incorporating basic fibroblast growth factor enhanced bone regeneration of the devascularized sternum. The purpose of this study was to determine if topical use of the gelatin sheet accelerated normal sternal regeneration and bone remodeling.

Methods. Thirty Wistar rats had median sternotomy and were divided into 3 groups: 10 had the bilateral internal thoracic arteries removed and basic fibroblast growth factor sheet applied on the sternum (group A), 10 had just the bilateral internal thoracic arteries removed (group B), and 10 had intact bilateral internal thoracic arteries (group C).

Results. Four weeks later the peristernal blood flow significantly increased and marked angiogenesis was seen around the sternum in group A. Histologically, the sternum was almost completely healed only in group A. In group A the bone mineral content was highest, but the bone mineral density was similar to that in other groups. The osteoclast index in group A was highest at the border zone of bone formation and remained high in regenerated bone.

Conclusions. The basic fibroblast growth factor sheet offset sternal ischemia and accelerated normal sternal bone regeneration and remodeling, not only by callus formation but also by callus resorption.

This article has been cited by other articles:

				A. Iwakura, Y. Tabata, T. Koyama, K. Doi, K. Nishimura, K. Kataoka, M. Fujita, and M. Komeda Gelatin sheet incorporating basic fibroblast growth factor enhances sternal healing after harvesting bilateral internal thoracic arteries J. Thorac. Cardiovasc. Surg., October 1, 2003; 126(4): 1113 - 1120. [Abstract] [Full Text] [PDF]

				A. Iwakura, Y. Tabata, N. Tamura, K. Doi, K. Nishimura, T. Nakamura, Y. Shimizu, M. Fujita, and M. Komeda Gelatin Sheet Incorporating Basic Fibroblast Growth Factor Enhances Healing of Devascularized Sternum in Diabetic Rats Circulation, September 18, 2001; 104 (2009): I-325 - I-329. [Abstract] [Full Text] [PDF]