HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Adam E. Saltman Irvin B. Krukenkamp Sidney Levitsky Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Saltman, A. E. Articles by Levitsky, S. Search for Related Content PubMed PubMed Citation Articles by Saltman, A. E. Articles by Levitsky, S.

Ann Thorac Surg 2000;70:595-601
© 2000 The Society of Thoracic Surgeons

---

Original articles: cardiovascular

Pharmacological preconditioning with the adenosine triphosphate–sensitive potassium channel opener pinacidil

^a Division of Cardiothoracic Surgery, University Hospital at Stony Brook and the State University of New York, Stony Brook, New York, USA
^b Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA

Address reprint requests to Dr Saltman, Division of Cardiothoracic Surgery, State University of New York at Stony Brook, T19, 080 Health Sciences Center, Stony Brook, NY 11794-8191
e-mail: saltman{at}surg.som.sunysb.edu

Background. Ischemic preconditioning (IPC) decreases infarct size after global or regional ischemia. Potassium channel openers also precondition but are subject to dose-limiting vasodilation. We compared the mechanical and electrophysiological effects of ischemic and pharmacological preconditioning in an isolated rabbit heart model.

Methods. Rabbit hearts were preconditioned with either 10 µmol/L pinacidil alone (P-), 10 µmol/L pinacidil with 10 µmol/L phenylephrine (P+), or two cycles of global ischemia and reperfusion (IPC) before 1 hour of LAD occlusion. Left ventricular pressure, epicardial monophasic action potential duration (APD) and coronary flow were monitored throughout. Infarct size was determined at the end of reperfusion.

Results. Regional ischemia uniformly decreased APD (p < 0.05). During reperfusion, APDs were prolonged beyond preischemic values in all preconditioned groups (p < 0.05). P- and P+ reduced the incidence of fibrillation. P- significantly increased coronary flow (+15%, p = 0.001), whereas IPC and P+ did not. However, IPC and P- significantly decreased systolic function (p < 0.05) but P+ did not. In addition, IPC depressed diastolic function (p < 0.05) but P- and P+ did not. Infarct size was reduced by all methods (p < 0.05).

Conclusions. Pinacidil presents a safe and effective alternative to IPC for preserving the heart during regional ischemia. Its coronary vasodilatory effects are safely and effectively reversed by the addition of phenylephrine.

This article has been cited by other articles:

				A. E. Saltman, T. O. Aksehirli, V. Valiunas, G. R. Gaudette, N. Matsuyama, P. Brink, and I. B. Krukenkamp Gap junction uncoupling protects the heart against ischemia J. Thorac. Cardiovasc. Surg., August 1, 2002; 124(2): 371 - 376. [Abstract] [Full Text] [PDF]

				J. Coromilas, C. Costeas, B. Deruyter, S. M. Dillon, N. S. Peters, and A. L. Wit Effects of Pinacidil on Electrophysiological Properties of Epicardial Border Zone of Healing Canine Infarcts: Possible Effects of KATP Channel Activation Circulation, May 14, 2002; 105(19): 2309 - 2317. [Abstract] [Full Text] [PDF]

				R. M. Mentzer Jr Ischemic preconditioning: how close are we to therapeutic implementation? Ann. Thorac. Surg., August 1, 2000; 70(2): 356 - 357. [Full Text] [PDF]