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Richard J. Kaplon
Delos M. Cosgrove, III
A. Marc Gillinov
Bruce W. Lytle
Eugene H. Blackstone
Nicholas G. Smedira
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Ann Thorac Surg 2000;70:438-441
© 2000 The Society of Thoracic Surgeons

Original articles: cardiovascular

Cardiac valve replacement in patients on dialysis: influence of prosthesis on survival

Richard J. Kaplon, MDa, Delos M. Cosgrove, III, MDa, A. Marc Gillinov, MDa, Bruce W. Lytle, MDa, Eugene H. Blackstone, MDa, Nicholas G. Smedira, MDa

a Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio, USA

Address reprint requests to Dr Smedira, Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, 9500 Euclid Ave/F25, Cleveland, OH 44195
e-mail: smedirn{at}ccf.org

Background. Mechanical valves have been recommended for patients on dialysis because of purported accelerated bioprosthesis degeneration. This study was undertaken to determine time-related outcomes in dialysis patients requiring cardiac valve replacement.

Methods. From 1986 to 1998, 42 patients on chronic preoperative dialysis underwent valve replacement; 17 received mechanical valves and 25 received bioprostheses. Age was similar in both groups: 54 ± 18.5 years (mechanical) and 59 ± 15.5 years (bioprosthetic, p = 0.4). Sites of valve replacement were aortic (27), mitral (11), and aortic and mitral (4). Follow-up was 100% complete.

Results. Survival at 3 and 5 years was 50% and 33% after mechanical valve replacement, and 36% and 27% after bioprosthetic valve replacement (p = 0.3). Four patients with bioprostheses required reoperation: 3 for allograft endocarditis and 1 at 10 months for mitral bioprosthesis degeneration. One patient who received a mechanical valve required reoperation.

Conclusions. Prosthetic valve-related complications in patients on dialysis were similar for both mechanical and bioprosthetic valves. Because of the limited life expectancy of patients on dialysis, bioprosthesis degeneration will be uncommon. Therefore, surgeons should not hesitate to implant bioprosthetic valves in these patients.




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