| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 2000;70:258-263
© 2000 The Society of Thoracic Surgeons
a Services of Thoracic Surgery and Pathology, University Hospital, Valladolid, Spain; and Members of the Spanish Multicenter Study of Neuroendocrine Tumors of the Lung of the Spanish Society of Pneumonology and Thoracic Surgery (EMETNE-SEPAR)
Address reprint requests to Dr García-Yuste, Thoracic Surgery Service, University Hospital, C/. Ramón y Cajal, 3, 47005 Valladolid, Spain
Background. This study examines the experience of the Spanish Multicenter Study of Neuroendocrine Tumors of the Lung through the clinical data and behavior of patients treated for this pathologic process.
Methods. From 1980 to 1997, 361 cases of neuroendocrine carcinomas (NEC) were treated surgically. Patients were enrolled in a protocol using the pathologic and follow-up reports. According to Dreslers’ criteria, the cases were segregated into grade 1 (typical carcinoid), grade 2 (atypical carcinoid), grade 3 large cell type, and grade 3 small cell type. Several variables were reviewed in all patients. Statistical analysis was performed to determine whether clinical characteristics and differentiation were associated with significant differences in the prognosis.
Results. A total of 261 cases of NEC were identified with grade 1, 43 with grade 2, and with grade 3: 22 of large and 35 of small cells. Five-year survival for different grades was as follows: grade 1, 96%; 2, 72%; 3 large cell type, 21%; and 3 small cell type, 14%. When a comparative analysis between typical and atypical carcinoids was performed a significant difference for mean age, tumor size, nodal metastases, and recurrence was observed. However, female sex, nodal metastases, and recurrence rate differed between atypical carcinoids and grade 3 NEC of large cells. A difference in recurrence rate was found between patients with both types of grade 3 NEC.
Conclusions. The progressive deterioration of tumor organization highlights that neuroendocrine tumors constitute a continuous spectrum. A careful observation of pathologic findings is necessary to individualize their prognostic factors.
This article has been cited by other articles:
|
|
 |
|
  C. A. Moran, S. Suster, D. Coppola, and M. R. Wick Neuroendocrine Carcinomas of the Lung: A Critical Analysis Am J Clin Pathol, February 1, 2009; 131(2): 206 - 221. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Rea, G. Rizzardi, A. Zuin, G. Marulli, S. Nicotra, R. Bulf, M. Schiavon, and F. Sartori Outcome and surgical strategy in bronchial carcinoid tumors: single institution experience with 252 patients Eur. J. Cardiothorac. Surg., February 1, 2007; 31(2): 186 - 191. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Garcia-Yuste, J. M. Matilla, A. Cueto, J. M. R. Paniagua, G. Ramos, M. A. Canizares, I. Muguruza, and Members of the Spanish Multi-centric Study of Neur Typical and atypical carcinoid tumours: analysis of the experience of the Spanish Multi-centric Study of Neuroendocrine Tumours of the Lung Eur. J. Cardiothorac. Surg., February 1, 2007; 31(2): 192 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Asamura, T. Kameya, Y. Matsuno, M. Noguchi, H. Tada, Y. Ishikawa, T. Yokose, S.-X. Jiang, T. Inoue, K. Nakagawa, et al. Neuroendocrine Neoplasms of the Lung: A Prognostic Spectrum J. Clin. Oncol., January 1, 2006; 24(1): 70 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Rossi, A. Cavazza, A. Marchioni, L. Longo, M. Migaldi, G. Sartori, N. Bigiani, L. Schirosi, C. Casali, U. Morandi, et al. Role of Chemotherapy and the Receptor Tyrosine Kinases KIT, PDGFR{alpha}, PDGFR{beta}, and Met in Large-Cell Neuroendocrine Carcinoma of the Lung J. Clin. Oncol., December 1, 2005; 23(34): 8774 - 8785. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Battafarano, F. G. Fernandez, J. Ritter, B. F. Meyers, T. J. Guthrie, J. D. Cooper, and G. A. Patterson Large cell neuroendocrine carcinoma: An aggressive form of non-small cell lung cancer J. Thorac. Cardiovasc. Surg., July 1, 2005; 130(1): 166 - 172. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Deb, F. C. Nichols, M. S. Allen, C. Deschamps, S. D. Cassivi, and P. C. Pairolero Pulmonary Carcinoid Tumors With Cushing's Syndrome: An Aggressive Variant or Not? Ann. Thorac. Surg., April 1, 2005; 79(4): 1132 - 1136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Ab' Saber, L. M. Massoni Neto, C. P. Bianchi, B. B. Ctenas, E. R. Parra, E. M. Eher, J. C. Pereira, T. Takagaki, N. H. Yamaguchi, and V. L. Capelozzi Neuroendocrine and biologic features of primary tumors and tissue in pulmonary large cell carcinomas Ann. Thorac. Surg., June 1, 2004; 77(6): 1883 - 1890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Cardillo, F. Sera, M. Di Martino, P. Graziano, R. Giunti, L. Carbone, F. Facciolo, and M. Martelli Bronchial carcinoid tumors: nodal status and long-term survival after resection Ann. Thorac. Surg., May 1, 2004; 77(5): 1781 - 1785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Casali, A. Stefani, G. Rossi, M. Migaldi, S. Bettelli, A. Parise, and U. Morandi The prognostic role of c-kit protein expression in resected large cell neuroendocrine carcinoma of the lung Ann. Thorac. Surg., January 1, 2004; 77(1): 247 - 252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zacharias, A. G. Nicholson, G. P. Ladas, and P. Goldstraw Large cell neuroendocrine carcinoma and large cell carcinomas with neuroendocrine morphology of the lung: prognosis after complete resection and systematic nodal dissection Ann. Thorac. Surg., February 1, 2003; 75(2): 348 - 352. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Ruffini, O. Rena, A. Oliaro, P. L. Filosso, M. Bongiovanni, A. Arslanian, E. Papalia, and G. Maggi Lung tumors with mixed histologic pattern. Clinico-pathologic characteristics and prognostic significance Eur. J. Cardiothorac. Surg., November 1, 2002; 22(5): 701 - 707. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Takei, H. Asamura, A. Maeshima, K. Suzuki, H. Kondo, T. Niki, T. Yamada, R. Tsuchiya, and Y. Matsuno Large cell neuroendocrine carcinoma of the lung: A clinicopathologic study of eighty-seven cases J. Thorac. Cardiovasc. Surg., August 1, 2002; 124(2): 285 - 292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Ginsberg Small cell lung cancer: how should we treat it? what is it? Ann. Thorac. Surg., November 1, 2000; 70(5): 1453 - 1454. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
