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Ann Thorac Surg 2000;69:1907-1912
© 2000 The Society of Thoracic Surgeons

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Original articles: Cardiovascular

Randomized controlled study of inhaled nitric oxide after operation for congenital heart disease

^a Division of Pediatric Cardiology, University of Utah and Primary Children’s Medical Center, Salt Lake City, Utah, USA
^b Division of Cardiothoracic Surgery, University of Utah and Primary Children’s Medical Center, Salt Lake City, Utah, USA

Address reprint requests to Dr Day, Division of Pediatric Cardiology, Primary Children’s Medical Center, 100 North Medical Dr, Salt Lake City, UT 84113
e-mail: ron.day{at}hsc.utah.edu

Background. Inhaled nitric oxide selectively decreases pulmonary vascular resistance. This study was performed to determine whether inhaled nitric oxide decreases the incidence of pulmonary hypertensive crises after corrective procedures for congenital heart disease.

Methods. Patients with a systolic pulmonary arterial pressure of 50% or more of the systolic systemic arterial pressure during the early postoperative period were randomized to receive 20 parts per million inhaled nitric oxide (n = 20) or conventional therapy alone (n = 20). Acute hemodynamic and blood gas measurements were performed at the onset of therapy. The efficacy of sustained therapy was determined by comparing the number of patients in each group who experienced a pulmonary hypertensive crisis.

Results. In comparison to controls, there were no significant differences in the baseline and 1-hour measurements of patients who were treated with nitric oxide. Four patients in the control group and 3 patients in the nitric oxide group experienced a pulmonary hypertensive crisis.

Conclusions. Nitric oxide did not substantially improve pulmonary hemodynamics and gas exchange immediately after operation for congenital heart disease. Nitric oxide also failed to significantly decrease the incidence of pulmonary hypertensive crises.

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