ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Christopher G.A. McGregor
John A. Macoviak
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Boston, U. S.
Right arrow Articles by Cook, D. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Boston, U. S.
Right arrow Articles by Cook, D. J.

Ann Thorac Surg 2000;69:1346-1350
© 2000 The Society of Thoracic Surgeons

Original articles: Cardiovascular

Differential perfusion: a new technique for isolated brain cooling during cardiopulmonary bypass

Umar S. Boston, MDa, Hulya Sungurtekin, MDb, Christopher G.A. McGregor, FRCSa, John A. Macoviak, MDa, David J. Cook, MDb

a Divisions of Division of Cardiothoracic Surgery, Mayo Foundation and Mayo Clinic, Rochester, Minnesota, USA
b Division of Cardiothoracic Anesthesiology, Mayo Foundation and Mayo Clinic, Rochester, Minnesota, USA

Address reprint requests to Dr Cook, Mayo Foundation, 200 First St SW, Rochester, MN 55905
e-mail: cook.david{at}mayo.edu

Background. The purpose of this study was to determine the feasibility of differential perfusion of the aortic arch and descending aorta during cardiopulmonary bypass using a cannula designed for aortic segmentation.

Methods. Pigs weighing 57 kg (n = 8), underwent cardiopulmonary bypass using the dual lumen aortic cannula. An inflatable balloon separated proximal (aortic arch) and distal (descending aorta) ports. During differential perfusion, the aorta was segmented and the arch and descending aorta perfused differentially using parallel heat exchangers. Ability to independently control brain and body temperature, cardiopulmonary bypass flow rate and mean arterial blood pressure was determined.

Results. During differential perfusion cerebral hypothermia (27°C) with systemic normothermia (38°C) was established in 23 minutes. Independent control of arch and descending aortic flow and mean arterial blood pressure was possible. Analysis of internal jugular venous O2 saturation data indicated an increase in the ratio of cerebral O2 supply to demand during differential perfusion.

Conclusions. A cannulation system segmenting the aorta allows independent control of cerebral and systemic perfusion. This device could provide significant cerebral protection while maintaining the advantages of warm systemic cardiopulmonary bypass temperatures.




This article has been cited by other articles:


Home page
 J. Thorac. Cardiovasc. Surg.Home page
J. W. Hammon
Aortic nightmares: Can we sleep better?
J. Thorac. Cardiovasc. Surg., June 1, 2003; 125(6): 1200 - 1201.
[Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
D. J. Cook, T. A. Orszulak, K. J. Zehr, N. A. Nussmeier, J. J. Livesay, J. W. Hammon, and X. Chen
Effectiveness of the Cobra aortic catheter for dual-temperature management during adult cardiac surgery
J. Thorac. Cardiovasc. Surg., February 1, 2003; 125(2): 378 - 384.
[Abstract] [Full Text] [PDF]

Home page
 SEMIN CARDIOTHORAC VASC ANESTHHome page
T. W. Willcox and R. van Uden
Best Practice for Cardiopulmonary Bypass in the High-Risk Elderly Patient
Seminars in Cardiothoracic and Vascular Anesthesia, December 1, 2002; 6(4): 293 - 300.
[Abstract] [PDF]

Home page
 Ann. Thorac. Surg.Home page
D. J. Cook, K. J. Zehr, and T. A. Orszulak
Reduction in brain embolization using the aegis aortic cannula during bypass in swine
Ann. Thorac. Surg., September 1, 2002; 74(3): 825 - 829.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
J. M. Slater, T. A. Orszulak, K. J. Zehr, and D. J. Cook
Use of the Cobra catheter for targeted temperature management during cardiopulmonary bypass in swine
J. Thorac. Cardiovasc. Surg., May 1, 2002; 123(5): 936 - 942.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
D. J. Cook, K. J. Zehr, T. A. Orszulak, and J. M. Slater
Profound reduction in brain embolization using an endoaortic baffle during bypass in swine
Ann. Thorac. Surg., January 1, 2002; 73(1): 198 - 202.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
J. A. Macoviak, J. Hwang, K. L. Boerjan, and D. D. Deal
Comparing dual-stream and standard cardiopulmonary bypass in pigs
Ann. Thorac. Surg., January 1, 2002; 73(1): 203 - 208.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
J. M. Murkin
Attenuation of neurologic injury during cardiac surgery
Ann. Thorac. Surg., November 1, 2001; 72(5): S1838 - 1844.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
K. H. Rehfeldt and D. J. Cook
Transesophageal Echocardiographic Imaging of a New Aortic Cannula for Differential Perfusion During Cardiopulmonary Bypass
Anesth. Analg., February 1, 2001; 92(2): 338 - 340.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2000 by The Society of Thoracic Surgeons.