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Ann Thorac Surg 2000;69:1130-1134
© 2000 The Society of Thoracic Surgeons

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ORIGINAL ARTICLES: CARDIOVASCULAR

Effect of cerebral embolization on regional autoregulation during cardiopulmonary bypass in dogs

^a Departments of Anesthesiology and Cardiovascular Surgery, Mayo Foundation and Mayo Clinic, Rochester, Minnesota, USA

Address reprint requests to Dr Cook, Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905
e-mail: cook.david{at}mayo.edu

Background. Embolization during cardiopulmonary bypass probably alters cerebral autoregulation. Therefore, using laser Doppler flowmetry we investigated the cerebral blood flow velocity changes in response to changes in arterial pressure, before and after embolization in a canine bypass model.

Methods. After Institutional Animal Care and Use Committee approval, 8 anesthetized dogs had a laser Doppler flow probe positioned over the temporoparietal dura. During 37° C cardiopulmonary bypass, the cerebral blood flow velocity response to changing mean arterial pressure (40 to 85 mm Hg in random order) was assessed before and after systemic embolization of 100 mg of 97-µm latex microspheres.

Results. Before embolization, cerebral blood flow velocity increased 39% as mean arterial pressure increased from 40 to 85 mm Hg. Following embolization, a 94% increase in cerebral blood flow velocity was demonstrated over the same mean arterial pressure range. The slopes of the curves relating cerebral blood flow velocity to mean arterial pressure were 0.21 ± 0.74 and 1.31 ± 0.87, before and after embolization (p = 0.016) respectively.

Conclusions. Regional cerebral blood flow autoregulation may be impaired by microembolization known to occur during cardiopulmonary bypass, increasing the dependence of cerebral blood flow on mean arterial pressure.

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