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Ann Thorac Surg 2000;69:944-946
© 2000 The Society of Thoracic Surgeons

Case Reports

Mediastinal amyloidosis

John D. Urschel, MDa, Dorothy M. Urschel, MSa

a Department of Thoracic Surgical Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA

Address reprint requests to Dr Urschel, Department of Surgery, St. Joseph’s Hospital, 50 Charlton Ave E, Hamilton, ON, Canada L8N 4A6
e-mail: urschelj{at}fhs.mcmaster.ca

Systemic amyloidosis is an unusual cause of mediastinal lymphadenopathy. Thoracic surgeons are often called upon to establish a diagnosis in patients with mediastinal lymphadenopathy, so familiarity with mediastinal amyloidosis is valuable. We report our experience with 2 patients, and discuss the diagnostic role of mediastinoscopy and other less invasive biopsy techniques. General anesthesia may pose significant risks in this disease; nonoperative biopsy techniques should be considered if the diagnosis of amyloidosis is suspected.




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