HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Scott D. Lick Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lick, S. D. Articles by Johnston, W. E. Search for Related Content PubMed PubMed Citation Articles by Lick, S. D. Articles by Johnston, W. E. Related Collections Related Article

Ann Thorac Surg 2000;69:910-912
© 2000 The Society of Thoracic Surgeons

---

Original Articles

Technique of controlled reperfusion of the transplanted lung in humans

^a Divisions of Division of Cardiothoracic Surgery, The University of Texas Medical Branch, Galveston, Texas, USA
^b Division of Cardiothoracic Anesthesiology, The University of Texas Medical Branch, Galveston, Texas, USA

Address reprint requests to Dr Lick, Division of Cardiothoracic Surgery, University of Texas Medical Branch, Galveston, TX 77555-0528.
e-mail: slick{at}utmb.edu

Background. Reperfusion injury remains a significant and sometimes fatal problem in clinical lung transplantation. Controlled reperfusion of the transplanted lung using white cell–filtered, nutrient-enriched blood has been shown recently to significantly ameliorate reperfusion damage in a porcine model. We modified this experimental technique and applied it to human lung transplantation.

Methods. Approximately 1,500 mL of arterial blood was slowly collected in a cardiotomy reservoir during the lung implant, and mixed to make a 4:1 solution of blood:modified Buckberg perfusate. This solution was passed through a leukocyte filter and into the transplant pulmonary artery for 10 minutes, at a controlled rate (200 mL/min) and pressure (less than 20 mm Hg), immediately before removal of the vascular clamp.

Results. Five patients underwent lung transplantation (1 bilateral, 4 single lung) using this technique. All patients were ventilated on a 40% fraction of inspired oxygen within a few hours and extubated on or before the first postoperative day.

Conclusions. Controlled reperfusion of the transplanted lung with white cell–filtered, nutrient-enriched blood has given excellent functional results in our small initial clinical series.

Related Article

Ari Halldorsson
Ann. Thorac. Surg. 2000 69: 912. [Extract] [Full Text] [PDF]

This article has been cited by other articles:

				C. L. Lau, G. A. Patterson, and S. M. Palmer Critical Care Aspects of Lung Transplantation J Intensive Care Med, March 1, 2004; 19(2): 83 - 104. [Abstract] [PDF]

				A. Ardehali, H. Laks, H. Russell, M. Levine, R. Shpiner, S. Lackey, and D. Ross Modified reperfusion and ischemia-reperfusion injury in human lung transplantation J. Thorac. Cardiovasc. Surg., December 1, 2003; 126(6): 1929 - 1934. [Abstract] [Full Text] [PDF]

				S. C. Clark, J. N. Rao, P. A. Flecknell, and J. H. Dark Pentoxifylline is as effective as leukocyte depletion for modulating pulmonary reperfusion injury J. Thorac. Cardiovasc. Surg., December 1, 2003; 126(6): 2052 - 2057. [Abstract] [Full Text] [PDF]

				C.L. Lau and G.A. Patterson Current status of lung transplantation Eur. Respir. J., November 16, 2003; 22(47_suppl): 57s - 64s. [Abstract] [Full Text] [PDF]

				F. R Rega, E. J Vandezande, N. C Jannis, G. M Verleden, T. E Lerut, and D. E. Van Raemdonck The role of leukocyte depletion in ex vivo evaluation of pulmonary grafts from (non-)heart-beating donors Perfusion, January 1, 2003; 18(1_suppl): 13 - 21. [Abstract] [PDF]

				W. Y. Szeto, D. Kreisel, G. C. Karakousis, A. Pochettino, D. H. Sterman, R. M. Kotloff, S. M. Arcasoy, D. A. Zisman, N. P. Blumenthal, R. J. Gallop, et al. Cardiopulmonary bypass for bilateral sequential lung transplantation in patients with chronic obstructive pulmonary disease without adverse effect on lung function or clinical outcome J. Thorac. Cardiovasc. Surg., August 1, 2002; 124(2): 241 - 249. [Abstract] [Full Text] [PDF]

				L. B. Becker, M. L. Weisfeldt, M. H. Weil, T. Budinger, J. Carrico, K. Kern, G. Nichol, I. Shechter, R. Traystman, C. Webb, et al. The PULSE Initiative: Scientific Priorities and Strategic Planning for Resuscitation Research and Life Saving Therapies Circulation, May 28, 2002; 105(21): 2562 - 2570. [Full Text] [PDF]

				B. S Allen The role of leukodepletion in limiting ischemia/reperfusion damage in the heart, lung and lower extremity Perfusion, March 1, 2002; 17(2_suppl): 11 - 22. [Abstract] [PDF]

				M. Kurusz, J. D Roach Jr, R. A Vertrees, M. K Girouard, and S. D Lick Leukocyte filtration in lung transplantation Perfusion, March 1, 2002; 17(2_suppl): 63 - 67. [Abstract] [PDF]

				S J Morris Leukocyte reduction in cardiovascular surgery Perfusion, September 1, 2001; 16(5): 371 - 380. [PDF]

				B. S. Allen Controlled pulmonary reperfusion: what is the optimal method of delivery? Ann. Thorac. Surg., October 1, 2000; 70(4): 1449 - 1450. [Full Text] [PDF]