ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Kenji Suzuki
Junji Yoshida
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Suzuki, K.
Right arrow Articles by Nishiwaki, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Suzuki, K.
Right arrow Articles by Nishiwaki, Y.

Ann Thorac Surg 2000;69:893-897
© 2000 The Society of Thoracic Surgeons

Original Articles

Prognostic significance of the size of central fibrosis in peripheral adenocarcinoma of the lung

Kenji Suzuki, MDa,b, Tomoyuki Yokose, MDb, Junji Yoshida, MDa, Mitsuyo Nishimura, MDa, Kenro Takahashi, MDa, Kanji Nagai, MDa, Yutaka Nishiwaki, MDa

a Division of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan
b Pathology Division, National Cancer Center Research Institute East, Chiba, Japan

Address reprint requests to Dr Suzuki, Division of Thoracic Surgery, National Cancer Center, Tsukiji 5 chome, 1-1, Chuo-ku, Tokyo, 104-0045 Japan
e-mail: kjsuzuki{at}ncc.go.jp

Background. The prognostic significance of the characteristics of central fibrosis in peripheral adenocarcinoma of the lung has been reported. However, the prognostic significance of the size of central fibrosis has never been evaluated.

Methods. A total of 100 consecutive surgically resected peripheral adenocarcinomas of the lung measuring 3.0 cm or less in maximum dimension were reviewed histologically, and the maximum dimension of central fibrosis was measured on conventional hematoxylin and eosin stain.

Results. Median follow-up for patients alive was 54 months. The overall 5-year survival rate was 75%. Twenty-one patients with adenocarcinoma having central fibrosis 5 mm or smaller in maximum dimension had a 5-year survival rate of 100%, whereas the other 79 patients had a 5-year survival less than 70%. Multivariate analysis showed the size of central fibrosis to be an independent prognostic factor as significant as vascular invasion and locoregional lymph node metastasis (p = 0.010, 0.024, and 0.024, respectively).

Conclusions. The size of central fibrosis is an independent prognostic factor in peripheral lung adenocarcinoma, as significant as the well-established prognostic factors vascular invasion and lymph node metastasis.




This article has been cited by other articles:


Home page
 Ann. Thorac. Surg.Home page
T. Koike, K.-i. Togashi, T. Shirato, S. Sato, H. Hirahara, M. Sugawara, F. Oguma, H. Usuda, and I. Emura
Limited resection for noninvasive bronchioloalveolar carcinoma diagnosed by intraoperative pathologic examination.
Ann. Thorac. Surg., October 1, 2009; 88(4): 1106 - 1111.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Dubey and C. A. Powell
Update in Lung Cancer 2008
Am. J. Respir. Crit. Care Med., May 15, 2009; 179(10): 860 - 868.
[Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
A. C. Borczuk, R. L. Toonkel, and C. A. Powell
Genomics of Lung Cancer
Proceedings of the ATS, April 15, 2009; 6(2): 152 - 158.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Aviel-Ronen, B. P. Coe, S. K. Lau, G. da Cunha Santos, C.-Q. Zhu, D. Strumpf, I. Jurisica, W. L. Lam, and M.-S. Tsao
Genomic markers for malignant progression in pulmonary adenocarcinoma with bronchioloalveolar features
PNAS, July 22, 2008; 105(29): 10155 - 10160.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
T. Hashizume, K. Yamada, N. Okamoto, H. Saito, F. Oshita, Y. Kato, H. Ito, H. Nakayama, Y. Kameda, and K. Noda
Prognostic Significance of Thin-Section CT Scan Findings in Small-Sized Lung Adenocarcinoma*
Chest, February 1, 2008; 133(2): 441 - 447.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
T. J. Kim, J.-H. Lee, C.-T. Lee, S. H. Jheon, S. W. Sung, J.-H. Chung, and K. W. Lee
Diagnostic Accuracy of CT-Guided Core Biopsy of Ground-Glass Opacity Pulmonary Lesions
Am. J. Roentgenol., January 1, 2008; 190(1): 234 - 239.
[Abstract] [Full Text] [PDF]

Home page
 Jpn J Clin OncolHome page
N. Yamada, M. Kusumoto, A. Maeshima, K. Suzuki, and Y. Matsuno
Correlation of the Solid Part on High-resolution Computed Tomography with Pathological Scar in Small Lung Adenocarcinomas
Jpn. J. Clin. Oncol., December 1, 2007; 37(12): 913 - 917.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
M. Mun and T. Kohno
Efficacy of thoracoscopic resection for multifocal bronchioloalveolar carcinoma showing pure ground-glass opacities of 20 mm or less in diameter.
J. Thorac. Cardiovasc. Surg., October 1, 2007; 134(4): 877 - 882.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
V. Donati, G. Fontanini, M. Dell'Omodarme, M. C. Prati, S. Nuti, M. Lucchi, A. Mussi, M. Fabbri, F. Basolo, C. M. Croce, et al.
WWOX Expression in Different Histologic Types and Subtypes of Non-Small Cell Lung Cancer
Clin. Cancer Res., February 1, 2007; 13(3): 884 - 891.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
M Tajiri, Y Kameda, H Nakayama, and K Sakamoto
Prognosis and morphometrical features of non-bronchioloalveolar cell adenocarcinoma: an assessment of the non-alveolar replacing area and high grade atypical area.
J. Clin. Pathol., March 1, 2006; 59(3): 269 - 273.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
K. Suzuki, M. Kusumoto, S.-i. Watanabe, R. Tsuchiya, and H. Asamura
Radiologic Classification of Small Adenocarcinoma of the Lung: Radiologic-Pathologic Correlation and Its Prognostic Impact
Ann. Thorac. Surg., February 1, 2006; 81(2): 413 - 419.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
K. Kernstine
Invited commentary
Ann. Thorac. Surg., February 1, 2006; 81(2): 419 - 420.
[Full Text] [PDF]

Home page
 ChestHome page
U. Tateishi, H. Uno, K. Yonemori, M. Satake, M. Takeuchi, and Y. Arai
Prediction of Lung Adenocarcinoma Without Vessel Invasion: A CT Scan Volumetric Analysis
Chest, November 1, 2005; 128(5): 3276 - 3283.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
B. Dong, M. Sato, A. Sakurada, M. Sagawa, C. Endo, S. Wu, S. Yamanaka, A. Horii, and T. Kondo
Computed tomographic images reflect the biologic behavior of small lung adenocarcinoma: They correlate with cell proliferation, microvascularization, cell adhesion, degradation of extracellular matrix, and K-ras mutation
J. Thorac. Cardiovasc. Surg., September 1, 2005; 130(3): 733 - 739.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
M. Nakata, S. Sawada, M. Yamashita, H. Saeki, A. Kurita, S. Takashima, and K. Tanemoto
Objective radiologic analysis of ground-glass opacity aimed at curative limited resection for small peripheral non-small cell lung cancer
J. Thorac. Cardiovasc. Surg., June 1, 2005; 129(6): 1226 - 1231.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
W. D. Travis, K. Garg, W. A. Franklin, I. I. Wistuba, B. Sabloff, M. Noguchi, R. Kakinuma, M. Zakowski, M. Ginsberg, R. Padera, et al.
Evolving Concepts in the Pathology and Computed Tomography Imaging of Lung Adenocarcinoma and Bronchioloalveolar Carcinoma
J. Clin. Oncol., May 10, 2005; 23(14): 3279 - 3287.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
K. Shimizu, K. Yamada, H. Saito, K. Noda, H. Nakayama, Y. Kameda, and K. Nakata
Surgically Curable Peripheral Lung Carcinoma: Correlation of Thin-Section CT Findings With Histologic Prognostic Factors and Survival
Chest, March 1, 2005; 127(3): 871 - 878.
[Abstract] [Full Text] [PDF]

Home page
 RadioGraphicsHome page
K. S. Lee, Y. J. Jeong, J. Han, B.-T. Kim, H. Kim, and O J. Kwon
T1 Non-Small Cell Lung Cancer: Imaging and Histopathologic Findings and Their Prognostic Implications
RadioGraphics, November 1, 2004; 24(6): 1617 - 1636.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
N. Ikeda, J. Maeda, K. Yashima, M. Tsuboi, H. Kato, S. Akada, and S. Okada
A clinicopathological study of resected adenocarcinoma 2 cm or less in diameter
Ann. Thorac. Surg., September 1, 2004; 78(3): 1011 - 1016.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
S. Yamada and T. Kohno
Video-assisted thoracic surgery for pure ground-glass opacities 2 cm or less in diameter
Ann. Thorac. Surg., June 1, 2004; 77(6): 1911 - 1915.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
K. Takamochi, J. Yoshida, M. Nishimura, T. Yokose, S. Sasaki, Y. Nishiwaki, K. Suzuki, and K. Nagai
Prognosis and histologic features of small pulmonary adenocarcinoma based on serum carcinoembryonic antigen level and computed tomographic findings
Eur. J. Cardiothorac. Surg., May 1, 2004; 25(5): 877 - 883.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
H. Nomori, T. Ohtsuka, T. Naruke, and K. Suemasu
Histogram analysis of computed tomography numbers of clinical T1 N0 M0 lung adenocarcinoma, with special reference to lymph node metastasis and tumor invasiveness
J. Thorac. Cardiovasc. Surg., November 1, 2003; 126(5): 1584 - 1589.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
H. Asamura, K. Suzuki, S.-i. Watanabe, Y. Matsuno, A. Maeshima, and R. Tsuchiya
A clinicopathological study of resected subcentimeter lung cancers: a favorable prognosis for ground glass opacity lesions
Ann. Thorac. Surg., October 1, 2003; 76(4): 1016 - 1022.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
M. Nakata, S. Sawada, H. Saeki, S. Takashima, H. Mogami, N. Teramoto, and K. Eguchi
Prospective study of thoracoscopic limited resection for ground-glass opacity selected by computed tomography
Ann. Thorac. Surg., May 1, 2003; 75(5): 1601 - 1605.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
T. Koike, Y. Yamato, K. Yoshiya, T. Shimoyama, and R. Suzuki
Intentional limited pulmonary resection for peripheral T1 N0 M0 small-sized lung cancer
J. Thorac. Cardiovasc. Surg., April 1, 2003; 125(4): 924 - 928.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
P. K. Shah, J. H. M. Austin, C. S. White, P. Patel, L. B. Haramati, G. D. N. Pearson, M. C. Shiau, and Y. M. Berkmen
Missed Non-Small Cell Lung Cancer: Radiographic Findings of Potentially Resectable Lesions Evident Only in Retrospect
Radiology, January 1, 2003; 226(1): 235 - 241.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
K. Suzuki, H. Asamura, M. Kusumoto, H. Kondo, and R. Tsuchiya
"Early" peripheral lung cancer: prognostic significance of ground glass opacity on thin-section computed tomographic scan
Ann. Thorac. Surg., November 1, 2002; 74(5): 1635 - 1639.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
B. Dong, M. Sato, M. Sagawa, C. Endo, K. Usuda, A. Sakurada, S. Wu, T. Oyaizu, I. Ishida, M. Handa, et al.
Computed tomographic image comparison between mediastinal and lung windows provides possible prognostic information in patients with small peripheral lung adenocarcinoma
J. Thorac. Cardiovasc. Surg., November 1, 2002; 124(5): 1014 - 1020.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
H. Matsuguma, K. Yokoi, M. Anraku, T. Kondo, Y. Kamiyama, K. Mori, K. Tominaga, Y. Tsuura, and S. Honjo
Proportion of ground-glass opacity on high-resolution computed tomography in clinical T1 N0 M0 adenocarcinoma of the lung: A predictor of lymph node metastasis
J. Thorac. Cardiovasc. Surg., August 1, 2002; 124(2): 278 - 284.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
K. Hiroshima, A. Iyoda, K. Shibuya, T. Toyozaki, Y. Haga, T. Fujisawa, and H. Ohwada
Prognostic significance of neuroendocrine differentiation in adenocarcinoma of the lung
Ann. Thorac. Surg., June 1, 2002; 73(6): 1732 - 1735.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
S.-i. Watanabe, T. Watanabe, K. Arai, T. Kasai, J. Haratake, and H. Urayama
Results of wedge resection for focal bronchioloalveolar carcinoma showing pure ground-glass attenuation on computed tomography
Ann. Thorac. Surg., April 1, 2002; 73(4): 1071 - 1075.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
E. A. Kim, T. Johkoh, K. S. Lee, J. Han, K. Fujimoto, J. Sadohara, P. S. Yang, T. Kozuka, O. Honda, and S. Kim
Quantification of Ground-Glass Opacity on High-Resolution CT of Small Peripheral Adenocarcinoma of the Lung: Pathologic and Prognostic Implications
Am. J. Roentgenol., December 1, 2001; 177(6): 1417 - 1422.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
F. Kumaki, K. Matsui, T. Kawai, Y. Ozeki, Z.-X. Yu, V. J. Ferrans, and W. D. Travis
Expression of Matrix Metalloproteinases in Invasive Pulmonary Adenocarcinoma with Bronchioloalveolar Component and Atypical Adenomatous Hyperplasia
Am. J. Pathol., December 1, 2001; 159(6): 2125 - 2135.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
K. Takamochi, K. Nagai, J. Yoshida, K. Suzuki, Y. Ohde, M. Nishimura, S. Sasaki, and Y. Nishiwaki
Pathologic N0 status in pulmonary adenocarcinoma is predictable by combining serum carcinoembryonic antigen level and computed tomographic findings
J. Thorac. Cardiovasc. Surg., August 1, 2001; 122(2): 325 - 330.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
J. Wu, Y. Ohta, H. Minato, Y. Tsunezuka, M. Oda, Y. Watanabe, and G. Watanabe
Nodal occult metastasis in patients with peripheral lung adenocarcinoma of 2.0 cm or less in diameter
Ann. Thorac. Surg., June 1, 2001; 71(6): 1772 - 1777.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
T. Koga, S. Hashimoto, K. Sugio, I. Yoshino, S. Mojtahedzadeh, Y. Matsuo, Y. Yonemitsu, K. Sugimachi, and K. Sueishi
Clinicopathological and Molecular Evidence Indicating the Independence of Bronchioloalveolar Components from Other Subtypes of Human Peripheral Lung Adenocarcinoma
Clin. Cancer Res., June 1, 2001; 7(6): 1730 - 1738.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2000 by The Society of Thoracic Surgeons.