| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 2000;69:847-850
© 2000 The Society of Thoracic Surgeons
a Department of Cardiothoracic Anaesthetics and Intensive Care, Karolinska Hospital, Stockholm, Sweden
b Department of Clinical Chemistry, Karolinska Hospital, Stockholm, Sweden
c Department of Thoracic Surgery, Karolinska Hospital, Stockholm, Sweden
Address reprint requests to Dr Anderson, Department of Cardiothoracic Anaesthetics and Intensive Care, Karolinska Hospital, S-171 76 Stockholm, Sweden
e-mail: russell.anderson{at}kirurgi.ki.se
Background. An increase of S100ß in serum during cardiopulmonary bypass (CPB) has been interpreted as a sign of brain injury. Cardiotomy suction may cause fat embolization, and its role in the S100ß increase was examined.
Methods. Twenty coronary artery operation patients were randomly assigned to two groups, 10 with suction during CPB to cardiotomy reservoir (CR), 10 to cell saving device (CS). S100ß was measured (immunoassay) in blood from the patients and from cell saving device after processing. In 7 additional patients S100ß was measured in the cell saving device before processing and directly from the wound at sternotomy.
Results. Before anesthesia, serum S100ß was 0.03 ± 0.06 µg/L. At the end of CPB it was 2.47 ± 1.31 µg/L and 0.44 ± 0.27 µg/L (CR vs CS; p < 0.001). S100ß was 33 ± 12 µg/L in CS reservoir and 42 ± 18 µg/L in blood from the wound.
Conclusions. Most serum S100ß after CPB with cardiotomy suction may be of extracerebral origin. S100ß after CPB with cell saving device was the same as after off-pump operation. The interpretation that an increase in S100ß during CPB in patients reflects cerebral injury must be questioned.
This article has been cited by other articles:
|
|
 |
|
  N. Nagdyman, P. Ewert, K. Schmitt, M. Hubler, B. Stiller, C. Muller, and F. Berger Protein S-100 is present in extracerebral fluids before and after cardiac surgery in children Ann Clin Biochem, July 1, 2008; 45(4): 409 - 412. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Hammon Extracorporeal Circulation: Organ Damage Card. Surg. Adult, January 1, 2008; 3(2008): 389 - 414. [Full Text]
|
|
|
|
 |
|
 V. Mazzei, G. Nasso, G. Salamone, F. Castorino, A. Tommasini, and A. Anselmi Prospective Randomized Comparison of Coronary Bypass Grafting With Minimal Extracorporeal Circulation System (MECC) Versus Off-Pump Coronary Surgery Circulation, October 16, 2007; 116(16): 1761 - 1767. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D.C. Whitaker, A.J.E. Green, J. Stygall, M.J.G. Harrison, and S.P. Newman Evaluation of an alternative S100b assay for use in cardiac surgery: relationship with microemboli and neuropsychological outcome Perfusion, July 1, 2007; 22(4): 267 - 272. [Abstract] [PDF]
|
|
|
|
|
|
F. D. Rubens and H. Nathan Lessons learned on the path to a healthier brain: dispelling the myths and challenging the hypotheses. Perfusion, May 1, 2007; 22(3): 153 - 160. [Abstract] [PDF]
|
|
|
|
|
|
P. D Raymond, M. Radel, M. J Ray, A. D Hinton-Bayre, and N. A Marsh Investigation of factors relating to neuropsychological change following cardiac surgery. Perfusion, January 1, 2007; 22(1): 27 - 33. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Carrier, A. Denault, J. Lavoie, and L. P. Perrault Randomized controlled trial of pericardial blood processing with a cell-saving device on neurologic markers in elderly patients undergoing coronary artery bypass graft surgery. Ann. Thorac. Surg., July 1, 2006; 82(1): 51 - 55. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-J. Wang, H.-H. Wu, S.-Y. Fang, Y.-R. Yang, and A. C.-C. Tseng Serum S-100 {beta} Protein During Coronary Artery Bypass Graft Surgery With or Without Cardiopulmonary Bypass Ann. Thorac. Surg., October 1, 2005; 80(4): 1371 - 1374. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. P. Grocott and G. B. Mackensen Apolipoprotein E Genotype and S100{beta} After Cardiac Surgery: Is Inflammation the Link? Anesth. Analg., June 1, 2005; 100(6): 1869 - 1870. [Full Text] [PDF]
|
|
|
|
|
|
C. Baufreton, P. Allain, A. Chevailler, F. Etcharry-Bouyx, J. J. Corbeau, D. Legall, and J. L. de Brux Brain Injury and Neuropsychological Outcome After Coronary Artery Surgery Are Affected by Complement Activation Ann. Thorac. Surg., May 1, 2005; 79(5): 1597 - 1605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Svenmarker, K G Engstrom, T Karlsson, E Jansson, R Lindholm, and T Aberg Influence of pericardial suction blood retransfusion on memory function and release of protein S100B Perfusion, December 1, 2004; 19(6): 337 - 343. [Abstract] [PDF]
|
|
|
|
 |
|
 S. P. Talpahewa, A. T. Lovell, G. D. Angelini, and R. Ascione Effect of cardiopulmonary bypass on cortical cerebral oxygenation during coronary artery bypass grafting Eur. J. Cardiothorac. Surg., October 1, 2004; 26(4): 676 - 681. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. I. Hall Serum S-100{beta} protein and postoperative neurological dysfunction - ready for prime time?/La proteine serique S-100{beta} et la dysfonction neurologique postoperatoire - correlation prete pour une large diffusion? Can J Anesth, August 1, 2004; 51(7): 645 - 648. [Full Text] [PDF]
|
|
|
|
|
|
H. P. Grocott Invited commentary Ann. Thorac. Surg., July 1, 2004; 78(1): 52 - 53. [Full Text] [PDF]
|
|
|
|
 |
|
 R. Motallebzadeh and M. Jahangiri The effect of the dynamic air bubble trap on cerebral microemboli and S100{beta} J. Thorac. Cardiovasc. Surg., July 1, 2004; 128(1): 154 - 154. [Full Text] [PDF]
|
|
|
|
 |
|
 E. Stolz, T. Gerriets, A. Kluge, W.-P. Klovekorn, M. Kaps, and G. Bachmann Diffusion-Weighted Magnetic Resonance Imaging and Neurobiochemical Markers After Aortic Valve Replacement: Implications for Future Neuroprotective Trials? Stroke, April 1, 2004; 35(4): 888 - 892. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Motallebzadeh, R. Kanagasabay, M. Bland, J. C. Kaski, and M. Jahangiri S100 protein and its relation to cerebral microemboli in on-pump and off-pump coronary artery bypass surgery Eur. J. Cardiothorac. Surg., March 1, 2004; 25(3): 409 - 414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Talpahewa, R. Ascione, G. D. Angelini, and A. T. Lovell Cerebral cortical oxygenation changes during OPCAB surgery Ann. Thorac. Surg., November 1, 2003; 76(5): 1516 - 1522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ueno, Y. Iguro, H. Yamamoto, R. Sakata, Y. Kakihana, and K. Nakamura Serial measurement of serum S-100B protein as a marker of cerebral damage after cardiac surgery Ann. Thorac. Surg., June 1, 2003; 75(6): 1892 - 1897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Vaage and R. Anderson Biochemical markers of neurologic injury in cardiac surgery: The rise and fall of S100{beta} J. Thorac. Cardiovasc. Surg., March 1, 2003; 125(90030): S31 - 33. [Full Text] [PDF]
|
|
|
|
|
|
M de Baar, J C Diephuis, K G M Moons, J Holtkamp, R Hijman, and C J Kalkman The effect of zero-balanced ultrafiltration during cardiopulmonary bypass on S100b release and cognitive function Perfusion, January 1, 2003; 18(1): 9 - 14. [Abstract] [PDF]
|
|
|
|
|
|
J. W. Hammon Jr. and L. H. Edmunds Jr. Extracorporeal Circulation: Organ Damage Card. Surg. Adult, January 1, 2003; 2(2003): 361 - 388. [Full Text]
|
|
|
|
 |
|
 F. Michetti and D. Gazzolo S100B Protein in Biological Fluids: A Tool for Perinatal Medicine Clin. Chem., December 1, 2002; 48(12): 2097 - 2104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Dogan, K. Graubitz, T. Aybek, M. F. Khan, P. Kessler, A. Moritz, and G. Wimmer-Greinecker How safe is the port access technique in minimally invasive coronary artery bypass grafting? Ann. Thorac. Surg., November 1, 2002; 74(5): 1537 - 1543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Fromes, D. Gaillard, O. Ponzio, M. Chauffert, M.-F. Gerhardt, P. Deleuze, and O. M. Bical Reduction of the inflammatory response following coronary bypass grafting with total minimal extracorporeal circulation Eur. J. Cardiothorac. Surg., October 1, 2002; 22(4): 527 - 533. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. I Flom-Halvorsen, E Ovrum, F Brosstad, G Tangen, M A. Ringdal, and R Oystese Effects of two differently heparin-coated extracorporeal circuits on markers for brain and myocardial dysfunction Perfusion, September 1, 2002; 17(5): 339 - 345. [Abstract] [PDF]
|
|
|
|
|
|
R. Ascione, B. C. Reeves, M. H. Chamberlain, A. K. Ghosh, K. H.H. Lim, and G. D. Angelini Predictors of stroke in the modern era of coronary artery bypass grafting: a case control study Ann. Thorac. Surg., August 1, 2002; 74(2): 474 - 480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ascione, S. Al-Ruzzeh, K. Amer, and G. D Angelini Subsystem organ function during coronary surgery Perfusion, July 1, 2002; 17(4): 295 - 303. [Abstract] [PDF]
|
|
|
|
|
|
G. S. Aldea, L. O. Soltow, W. L. Chandler, C. M. Triggs, C. R. Vocelka, G. I. Crockett, Y. T. Shin, W. E. Curtis, and E. D. Verrier Limitation of thrombin generation, platelet activation, and inflammation by elimination of cardiotomy suction in patients undergoing coronary artery bypass grafting treated with heparin-bonded circuits J. Thorac. Cardiovasc. Surg., April 1, 2002; 123(4): 742 - 755. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Krishnadasan, C. R. Hampton, J. Griscavage-Ennis, R. J. Dabal, and E. D. Verrier Molecular Mechanisms of Neurologic Injury Following Cardiopulmonary Bypass Seminars in Cardiothoracic and Vascular Anesthesia, March 1, 2002; 6(1): 43 - 53. [Abstract] [PDF]
|
|
|
|
|
|
D C Whitaker, J A Stygall, S P Newman, and M J. Harrison The use of leucocyte-depleting and conventional arterial line filters in cardiac surgery: a systematic review of clinical studies Perfusion, December 1, 2001; 16(6): 433 - 446. [Abstract] [PDF]
|
|
|
|
|
|
S. Martens, M. Dietrich, S. Wals, S. Steffen, G. Wimmer-Greinecker, and A. Moritz Conventional carbon dioxide application does not reduce cerebral or myocardial damage in open heart surgery Ann. Thorac. Surg., December 1, 2001; 72(6): 1940 - 1944. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Vaage and R. Anderson Biochemical markers of neurologic injury in cardiac surgery: The rise and fall of S100{beta} J. Thorac. Cardiovasc. Surg., November 1, 2001; 122(5): 853 - 855. [Full Text] [PDF]
|
|
|
|
|
|
M. J. A. Robson, R. P. Alston, I. J. Deary, P. J. D. Andrews, and M. J. Souter Jugular Bulb Oxyhemoglobin Desaturation, S100{beta}, and Neurologic and Cognitive Outcomes After Coronary Artery Surgery Anesth. Analg., October 1, 2001; 93(4): 839 - 845. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-C. Hsu Heparin-coated cardiopulmonary bypass circuits: current status Perfusion, September 1, 2001; 16(5): 417 - 428. [Abstract] [PDF]
|
|
|
|
|
|
N. E. Khan, A. C. De Souza, and J. R. Pepper S100 protein: its use as a marker of cerebral damage in cardiac operations Ann. Thorac. Surg., August 1, 2001; 72(2): 666 - 667. [Full Text] [PDF]
|
|
|
|
|
|
D. Whitaker S100 release as an indicator of cerebral damage Ann. Thorac. Surg., June 1, 2001; 71(6): 2085 - 2085. [Full Text] [PDF]
|
|
|
|
|
|
W. Wandschneider S100 release as an indicator of cerebral damage: Reply Ann. Thorac. Surg., June 1, 2001; 71(6): 2085 - 2086. [Full Text] [PDF]
|
|
|
|
|
|
H. Jonsson, P. Johnsson, M. Birch-Iensen, C. Alling, S. Westaby, and S. Blomquist S100B as a predictor of size and outcome of stroke after cardiac surgery Ann. Thorac. Surg., May 1, 2001; 71(5): 1433 - 1437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Anderson, L.-O. Hansson, O. Nilsson, J. Liska, G. Settergren, and J. Vaage Increase in serum S100A1-B and S100BB during cardiac surgery arises from extracerebral sources Ann. Thorac. Surg., May 1, 2001; 71(5): 1512 - 1517. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Reents, J. Babin-Ebell, and O. Elert Remaining procoagulant property of wound blood washed by a cell-saving device: Reply Ann. Thorac. Surg., May 1, 2001; 71(5): 1749 - 1750. [Full Text] [PDF]
|
|
|
|
|
|
S. C. Stamou and P. J. Corso Coronary revascularization without cardiopulmonary bypass in high-risk patients: a route to the future Ann. Thorac. Surg., March 1, 2001; 71(3): 1056 - 1061. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Svenmarker, E. Sandstrom, T. Karlsson, S. Haggmark, E. Jansson, M. Appelblad, R. Lindholm, and T. Aberg Neurological and general outcome in low-risk coronary artery bypass patients using heparin coated circuits Eur. J. Cardiothorac. Surg., January 1, 2001; 19(1): 47 - 53. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Mack Pro: beating-heart surgery for coronary revascularization: is it the most important development since the introduction of the heart-lung machine? Ann. Thorac. Surg., November 1, 2000; 70(5): 1774 - 1778. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
