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Ann Thorac Surg 2000;69:696-702
© 2000 The Society of Thoracic Surgeons
a Cardiothoracic Research Laboratory, Carlyle Fraser Heart Center of Crawford Long Hospital, and Emory University School of Medicine, Atlanta, Georgia, USA
Address reprint requests to Dr Vinten-Johansen, Cardiothoracic Research Laboratory, Carlyle Fraser Heart Center of Crawford Long Hospital, 550 Peachtree St NE, Atlanta, GA 30365
e-mail: jvinten{at}emory.edu
Presented at the Forty-Fifth Annual Meeting of the Southern Thoracic Surgical Association, Orlando, FL, Nov 12–14, 1998.
Background. Multiple organ failure after deep hypothermic circulatory arrest (DHCA) may occur secondary to endothelial dysfunction and apoptosis. We sought to determine if DHCA causes endothelial dysfunction and apoptosis in brain, kidney, lungs, and other tissues.
Methods. Anesthetized pigs on cardiopulmonary bypass were: (1) cooled to 18°C, and had their circulation arrested (60 minutes) and reperfused at 37°C for 90 minutes (DHCA, n = 8); or (2) time-matched normothermic controls on bypass (CPB, n = 6). Endothelial function in cerebral, pulmonary, and renal vessels was assessed by vasorelaxation responses to endothelial-specific bradykinin (BK) or acetylcholine (ACh), and smooth muscle-specific nitroprusside.
Results. In vivo transcranial vasorelaxation responses to ACh were similar between the two groups. In small-caliber cerebral arteries, endothelial relaxation (BK) was impaired in CPB vs DHCA (maximal 55% ± 2% [p < 0.05] vs 100% ± 6%). Pulmonary artery ACh responses were comparable between CPB (110% ± 10%) and DHCA (83% ± 6%), but responses in pulmonary vein were impaired in DHCA (109% ± 3%, p < 0.05) relative to CPB (137% ± 6%). In renal arteries, endothelial (ACh) responses were impaired in DHCA (71% ± 13%) relative to CPB (129% ± 14%). Apoptosis (DNA laddering) occurred primarily in duodenal tissue, with a greater frequency in DHCA (56%, p < 0.05) compared with normothermic CPB (17%) and nonbypass controls (0%).
Conclusions. DHCA is associated with endothelial dysfunction in cerebral microvessels but not in the in vivo transcranial vasculature; in addition, endothelial dysfunction was noted in large-caliber renal arteries and pulmonary veins. DHCA is also associated with duodenal apoptosis. Vascular endothelial dysfunction and apoptosis may be involved in the pathophysiology of multisystem organ failure after DHCA.
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