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Ann Thorac Surg 2000;69:602-606
© 2000 The Society of Thoracic Surgeons

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Original Articles

Continuous pulmonary perfusion during cardiopulmonary bypass prevents lung injury in infants

^a Division of Cardiovascular Surgery, Tokyo Metropolitan Children’s Hospital, Tokyo, Japan

Address reprint requests to Dr Suzuki, Division of Cardiovascular Surgery, Tokyo Metropolitan Children’s Hospital, 1-3-1 Umezono, Kiyose-shi, Tokyo, 204-8567 Japan
e-mail: suzuki{at}chp.kiyose.tokyo.jp

Background. Lung injury after cardiopulmonary bypass is a serious complication for infants with congenital heart disease and pulmonary hypertension. Excessive neutrophil sequestration in the lung occurring after reestablishment of pulmonary circulation implies that interaction between neutrophils and pulmonary endothelium is the major cause of lung injury.

Methods. Thirty infants with either ventricular septal defect or atrioventricular septal defect and with pulmonary hypertension were enrolled in this study. We performed continuous pulmonary perfusion during total cardiopulmonary bypass on 16 patients (perfused group) and conventional cardiopulmonary bypass on 14 patients (control group). PaO₂/FiO₂ and neutrophil counts were assessed from immediately before surgery to 24 hours after termination of cardiopulmonary bypass.

Results. PaO₂/FiO₂ was higher in the perfused group than in the control group, and the difference was significant throughout the study period. Neutrophil counts decreased below prebypass values in both groups at 30 minutes after aortic unclamping, and the difference was significant in the control group but was not in the perfused group. Duration of postoperative ventilatory support was significantly less in the perfused group.

Conclusions. Our study demonstrates that arrested pulmonary circulation during cardiopulmonary bypass is the major risk factor of lung injury and that continuous pulmonary perfusion is effective in preventing lung injury.

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