HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Julie A. Swain Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Abraham, V. S. Articles by Musulin, M. M. Search for Related Content PubMed PubMed Citation Articles by Abraham, V. S. Articles by Musulin, M. M.

Ann Thorac Surg 2000;69:475-479
© 2000 The Society of Thoracic Surgeons

---

Original Articles

Ischemic preconditioning protects against paraplegia after transient aortic occlusion in the rat

^a Gill Heart Institute at the University of Kentucky College of Medicine, Lexington, Kentucky, USA

Address reprint requests to Dr Abraham, Division of Cardiovascular and Thoracic Surgery, University of Kentucky College of Medicine, 800 Rose St, MN 276, Lexington, KY 40536-0084
e-mail: vsabra{at}pop.uky.edu

Background. Paraplegia can result from operations requiring transient occlusion of the thoracic aorta. A rat model of paraplegia with the characteristics of delayed paraplegia and transient ischemic dysfunction was developed to determine whether ischemic preconditioning (IPC) improved neurologic outcome.

Methods. Rats underwent balloon occlusion of the upper descending thoracic aorta. One group (2 minute IPC, n = 19) underwent 2 minutes of IPC and a second group (5 minute IPC, n = 19) had 5 minutes of IPC 48 hours before 10 minutes of occlusion. The control group (n = 31) had no IPC prior to 10 minutes of occlusion.

Results. Paraplegia occurred in 68% of the control animals (21 of 31 paraplegic: 6 delayed and 15 immediate paraplegia). Both the 2-minute IPC and 5-minute IPC groups had a decreased incidence of paraplegia when compared to controls (32%, p = 0.011 and 26%, p = 0.009, respectively).

Conclusions. A rat model of spinal cord ischemia demonstrating both delayed paraplegia and transient ischemic dysfunction was characterized. Both 2-minute and 5-minute periods of IPC were found to protect against paraplegia.

This article has been cited by other articles:

				M. Basaran, E. Kafali, O. Sayin, M. Ugurlucan, M. H. Us, C. Bayindir, A. T. Yilmaz, and E. Dayioglu Heat stress increases the effectiveness of early ischemic preconditioning in spinal cord protection Eur. J. Cardiothorac. Surg., September 1, 2005; 28(3): 467 - 472. [Abstract] [Full Text] [PDF]

				C. S. Isbir, K. Ak, O. Kurtkaya, U. Zeybek, S. Akgun, B. W. Scheitauer, A. Sav, and A. Cobanoglu Ischemic preconditioning and nicotinamide in spinal cord protection in an experimental model of transient aortic occlusion Eur. J. Cardiothorac. Surg., June 1, 2003; 23(6): 1028 - 1033. [Abstract] [Full Text] [PDF]

				I. K. Toumpoulis, C. E. Anagnostopoulos, G. E. Drossos, V. D. Malamou-Mitsi, L. S. Pappa, and D. G. Katritsis Early ischemic preconditioning without hypotension prevents spinal cord injury caused by descending thoracic aortic occlusion J. Thorac. Cardiovasc. Surg., May 1, 2003; 125(5): 1030 - 1036. [Abstract] [Full Text] [PDF]

				P. Zhang, V. S. Abraham, K. R. Kraft, A. G. Rabchevsky, S. W. Scheff, and J. A. Swain Hyperthermic preconditioning protects against spinal cord ischemic injury Ann. Thorac. Surg., November 1, 2000; 70(5): 1490 - 1495. [Abstract] [Full Text] [PDF]