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Ann Thorac Surg 2000;69:254-258
© 2000 The Society of Thoracic Surgeons
a Department of Neurology, University of the Saarland, Homburg, Germany
b Department of Thoracic and Cardiovascular Surgery, University of the Saarland, Homburg, Germany
Address reprint requests to Dr Blaes, Department of Neurology, University of the Saarland, D-66421 Homburg, Germany;
e-mail: nefbla{at}krzsun.med-rz.uni-sb.de
Background. Autoantibodies against nervous system structures have been proven to be a prognostic factor in small cell lung cancer. However, little is known about humoral autoimmunity in non-small cell lung cancer (NSCLC) and its prognostic significance.
Methods. We examined antineural antibodies (AnAb) and antinuclear antibodies (ANA) in the sera of 61 patients with NSCLC (histologically: 29 adenocarcinoma, 32 squamous cell carcinoma). Twenty-one patients had stage I NSCLC, 11 stage II, and 29 patients stage III. Autoantibody detection was done by immunofluorescence test; Western blotting was used as a confirmation test.
Results. Of the NSCLC patients, 27.8% were antineural antibody positive, and 32.7% had ANA. No differences were found between the histological groups. AnAb-positive patients showed a better survival in all patients (p = 0.005). There was also a higher survival of ANA-positive patients, but this was only significant in stage III (p = 0.0025). Cox regression analysis showed that antineural and antinuclear antibodies are a stage-independent prognostic factor in NSCLC.
Conclusions. Antineural and antinuclear autoantibodies are a stage-independent prognostic factor in patients with NSCLC and may represent an effective immune response to the tumor.
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