ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Mark K. Ferguson
Jun Wang
Jemi Olak
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ferguson, M. K.
Right arrow Articles by Vokes, E. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ferguson, M. K.
Right arrow Articles by Vokes, E. E.

Ann Thorac Surg 2000;69:245-249
© 2000 The Society of Thoracic Surgeons

Original Articles

Sex-associated differences in survival of patients undergoing resection for lung cancer

Mark K. Ferguson, MDa, Jun Wang, MDa, Philip C. Hoffman, MDb, Daniel J. Haraf, MDc, Jemi Olak, MDa, Gregory A. Masters, MDb, Everett E. Vokes, MDb

a Department of Surgery, The University of Chicago, Chicago, Illinois, USA
b Department of Medicine, The University of Chicago, Chicago, Illinois, USA
c Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, Illinois, USA

Address reprint requests to Dr Ferguson, Department of Surgery, The University of Chicago, 5841 S Maryland Ave, MC 5035, Chicago, IL 60637
e-mail: mferguso{at}surgery.bsd.uchicago.edu

Background. The increasing incidence of lung cancer among women prompted us to assess whether sex-associated differences exist in the presentation and survival of patients who undergo major lung resection for lung cancer.

Methods. We performed a retrospective review of patients who had major lung resection for lung cancer from January 1980 to June 1998.

Results. There were 265 men and 186 women. Women were younger (60.7 ± 0.8 versus 63.6 ± 0.6 years; p = 0.005). Adenocarcinoma was more common among women (48% versus 40%; p = 0.001). Pathologic stages for men were: I = 43%, II = 26%, IIIA = 25%, IIIB or IV = 6%, and for women: I = 52%, II = 20%, IIIA = 22%, IIIB or IV = 6% (p = 0.146). Median survival was better for women (41.8 versus 26.9 months; p = 0.006). This was due both to a difference in stage at presentation and to a better median survival rate for adenocarcinoma compared with squamous cell cancer. The data suggest an association between sex and survival, although this failed to reach statistical significance. Sex influenced survival with a relative risk for women of 0.67 (95% confidence interval 0.35 to 1.29; p = 0.231 adjusted for stage, cell type, age, and spirometry).

Conclusions. There are sex-associated differences in the presentation and possibly in the survival of patients with lung cancer. This finding has possible implications regarding the selection of patients for therapy and for the design of randomized therapeutic trials.




This article has been cited by other articles:


Home page
 JCOHome page
J. P. Wisnivesky and E. A. Halm
Sex Differences in Lung Cancer Survival: Do Tumors Behave Differently in Elderly Women?
J. Clin. Oncol., May 1, 2007; 25(13): 1705 - 1712.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
N. Ramnath, T. L. Demmy, A. Antun, N. Natarajan, C. E. Nwogu, G. M. Loewen, and M. E. Reid
Pneumonectomy for Bronchogenic Carcinoma: Analysis of Factors Predicting Survival
Ann. Thorac. Surg., May 1, 2007; 83(5): 1831 - 1836.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
W.-H. Hsu, C.-S. Huang, H.-S. Hsu, W.-J. Huang, H.-C. Lee, B.-S. Huang, and M.-H. Huang
Preoperative Serum Carcinoembryonic Antigen Level is a Prognostic Factor in Women With Early Non-Small-Cell Lung Cancer
Ann. Thorac. Surg., February 1, 2007; 83(2): 419 - 424.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
International Early Lung Cancer Action Program Inv
Women's Susceptibility to Tobacco Carcinogens and Survival After Diagnosis of Lung Cancer
JAMA, July 12, 2006; 296(2): 180 - 184.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
A. I. Neugut and J. S. Jacobson
Women and lung cancer: gender equality at a crossroad?
JAMA, July 12, 2006; 296(2): 218 - 219.
[Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
C. Doddoli, B. D'Journo, F. Le Pimpec-Barthes, A. Dujon, C. Foucault, P. Thomas, and M. Riquet
Lung Cancer Invading the Chest Wall: A Plea for En-Bloc Resection but the Need for New Treatment Strategies
Ann. Thorac. Surg., December 1, 2005; 80(6): 2032 - 2040.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
L. Thomas, L. A. Doyle, and M. J. Edelman
Lung Cancer in Women: Emerging Differences in Epidemiology, Biology, and Therapy
Chest, July 1, 2005; 128(1): 370 - 381.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J. D. Patel
Lung Cancer in Women
J. Clin. Oncol., May 10, 2005; 23(14): 3212 - 3218.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. B. Fu, T. Y. Kau, R. K. Severson, and G. P. Kalemkerian
Lung Cancer in Women: Analysis of the National Surveillance, Epidemiology, and End Results Database
Chest, March 1, 2005; 127(3): 768 - 777.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
D. J. Barnes
The Changing Face of Lung Cancer
Chest, December 1, 2004; 126(6): 1718 - 1721.
[Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
A. L. Visbal, B. A. Williams, F. C. Nichols III, R. S. Marks, J. R. Jett, M.-C. Aubry, E. S. Edell, J. A. Wampfler, J. R. Molina, and P. Yang
Gender differences in non-small-cell lung cancer survival: an analysis of 4,618 patients diagnosed between 1997 and 2002
Ann. Thorac. Surg., July 1, 2004; 78(1): 209 - 215.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
T. Iizasa, M. Suzuki, K. Yasufuku, A. Iyoda, M. Otsuji, S. Yoshida, Y. Sekine, K. Shibuya, Y. Saitoh, K. Hiroshima, et al.
Preoperative pulmonary function as a prognostic factor for stage I non-small cell lung carcinoma
Ann. Thorac. Surg., June 1, 2004; 77(6): 1896 - 1902.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
C. Alexiou, D. Beggs, P. Onyeaka, K. Kotidis, S. Ghosh, L. Beggs, D. N. Hopkinson, J. P. Duffy, W. E. Morgan, and G. Rocco
Pneumonectomy for Stage I (T1N0 and T2N0) nonsmall cell lung cancer has potent, adverse impact on survival
Ann. Thorac. Surg., October 1, 2003; 76(4): 1023 - 1028.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
M. K. Ferguson and A. E. Durkin
A comparison of three scoring systems for predicting complications after major lung resection
Eur. J. Cardiothorac. Surg., January 1, 2003; 23(1): 35 - 42.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
E. Radzikowska, P. Glaz, and K. Roszkowski
Lung cancer in women: age, smoking, histology, performance status, stage, initial treatment and survival. Population-based study of 20 561 cases
Ann. Onc., July 1, 2002; 13(7): 1087 - 1093.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
C. Alexiou, C.V. P. Onyeaka, D. Beggs, R. Akar, L. Beggs, F. D. Salama, J. P. Duffy, and W. E. Morgan
Do women live longer following lung resection for carcinoma?
Eur. J. Cardiothorac. Surg., February 1, 2002; 21(2): 319 - 325.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
J. R. Handy Jr, A. I. Child, G. L. Grunkemeier, P. Fowler, J. W. Asaph, E. C. Douville, A. C. Tsen, and G. Y. Ott
Hospital readmission after pulmonary resection: prevalence, patterns, and predisposing characteristics
Ann. Thorac. Surg., December 1, 2001; 72(6): 1855 - 1860.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
C. Alexiou, D. Beggs, M. L. Rogers, L. Beggs, S. Asopa, and F. D. Salama
Pneumonectomy for non-small cell lung cancer: predictors of operative mortality and survival
Eur. J. Cardiothorac. Surg., September 1, 2001; 20(3): 476 - 480.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2000 by The Society of Thoracic Surgeons.