| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 1999;68:2069-2073
© 1999 The Society of Thoracic Surgeons
a Departments of Department of Thoracic Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
b Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
c Department of Radiology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
Address reprint requests to Dr Higashiyama, Department of Thoracic Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Nakamichi 1-3-3, Higashinariku, Osaka 537-8511, Japan
Abstract
Background. Bronchiolo-alveolar carcinoma (BAC) is often observed in lung adenocarcinoma, but its clinicopathological and prognostic significance, especially in small peripheral lung adenocarcinoma, remains undetermined.
Methods. We assessed 206 consecutive cases of surgically resected small peripheral lung adenocarcinoma (less than 2 cm in diameter) recorded between 1973 and 1997. According to the component area of well differentiated BAC within maximally cut surface specimens of tumor tissue, we semiquantitatively classified the tumors into four types: those in which the BAC component comprised 0% (type I), 1% to 49% (type II), 50% to 99% (type III), and 100% (type IV) of the tumor tissue.
Results. Forty tumors were classified as type I, 75 as type II, 74 as type III, and 17 as type IV. The tumors with less BAC, especially type I and II, showed a significantly more aggressive nodal involvement and tumor stage, and consequently a worse prognosis, while type IV tumors had no nodal involvement and the most favorable prognosis. The patients with type III showed clinicopathological characteristics somewhere between those of type II and type IV patients. Among stage I patients, however, those with type II had the worst prognosis, while those with type I showed as good a prognosis as the other two groups.
Conclusions. This novel classification based on the degree of BAC involvement in small peripheral lung adenocarcinoma may reflect clinicopathological and prognostic characteristics. This classification may prove practical for planning therapeutic strategies, in particular surgical treatment.
This article has been cited by other articles:
|
|
 |
|
  R. Rami-Porta and M. Tsuboi Sublobar resection for lung cancer Eur. Respir. J., February 1, 2009; 33(2): 426 - 435. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kodama, M. Higashiyama, K. Takami, K. Oda, J. Okami, J. Maeda, M. Koyama, and T. Nakayama Treatment strategy for patients with small peripheral lung lesion(s): intermediate-term results of prospective study Eur. J. Cardiothorac. Surg., November 1, 2008; 34(5): 1068 - 1074. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Hashizume, K. Yamada, N. Okamoto, H. Saito, F. Oshita, Y. Kato, H. Ito, H. Nakayama, Y. Kameda, and K. Noda Prognostic Significance of Thin-Section CT Scan Findings in Small-Sized Lung Adenocarcinoma* Chest, February 1, 2008; 133(2): 441 - 447. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ikeda, K. Awai, T. Mori, K. Kawanaka, Y. Yamashita, and H. Nomori Differential Diagnosis of Ground-Glass Opacity Nodules: CT Number Analysis by Three-Dimensional Computerized Quantification Chest, September 1, 2007; 132(3): 984 - 990. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ikeda, H. Nomori, T. Mori, H. Kobayashi, K. Iwatani, K. Yoshimoto, and K.-i. Kawanaka Impalpable Pulmonary Nodules With Ground-Glass Opacity: Success for Making Pathologic Sections With Preoperative Marking by Lipiodol Chest, February 1, 2007; 131(2): 502 - 506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Choi, D. K. Yang, C. H. Son, K. E. Lee, J. I. Lee, and M. S. Roh Fascin immunoreactivity for preoperatively predicting lymph node metastases in peripheral adenocarcinoma of the lung 3cm or less in diameter. Eur. J. Cardiothorac. Surg., September 1, 2006; 30(3): 538 - 542. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Tajiri, Y Kameda, H Nakayama, and K Sakamoto Prognosis and morphometrical features of non-bronchioloalveolar cell adenocarcinoma: an assessment of the non-alveolar replacing area and high grade atypical area. J. Clin. Pathol., March 1, 2006; 59(3): 269 - 273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Dong, M. Sato, A. Sakurada, M. Sagawa, C. Endo, S. Wu, S. Yamanaka, A. Horii, and T. Kondo Computed tomographic images reflect the biologic behavior of small lung adenocarcinoma: They correlate with cell proliferation, microvascularization, cell adhesion, degradation of extracellular matrix, and K-ras mutation J. Thorac. Cardiovasc. Surg., September 1, 2005; 130(3): 733 - 739. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nakata, S. Sawada, M. Yamashita, H. Saeki, A. Kurita, S. Takashima, and K. Tanemoto Objective radiologic analysis of ground-glass opacity aimed at curative limited resection for small peripheral non-small cell lung cancer J. Thorac. Cardiovasc. Surg., June 1, 2005; 129(6): 1226 - 1231. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-i. Takeda, S. Fukai, H. Komatsu, E. Nemoto, K. Nakamura, M. Murakami, and Japanese National Chest Hospital Study Group Impact of Large Tumor Size on Survival After Resection of Pathologically Node Negative (pN0) Non-Small Cell Lung Cancer Ann. Thorac. Surg., April 1, 2005; 79(4): 1142 - 1146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Shimizu, K. Yamada, H. Saito, K. Noda, H. Nakayama, Y. Kameda, and K. Nakata Surgically Curable Peripheral Lung Carcinoma: Correlation of Thin-Section CT Findings With Histologic Prognostic Factors and Survival Chest, March 1, 2005; 127(3): 871 - 878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Sakurai, Y. Dobashi, E. Mizutani, H. Matsubara, S. Suzuki, K. Takano, S. Shindo, and M. Matsumoto Bronchioloalveolar Carcinoma of the Lung 3 Centimeters or Less in Diameter: A Prognostic Assessment Ann. Thorac. Surg., November 1, 2004; 78(5): 1728 - 1733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. S. Sarkaria, D. Pham, R. A. Ghossein, S. G. Talbot, M. Hezel, M. E. Dudas, M. I. Ebright, S. Chuai, N. Memoli, E. S. Venkatraman, et al. SCCRO Expression Correlates With Invasive Progression in Bronchioloalveolar Carcinoma Ann. Thorac. Surg., November 1, 2004; 78(5): 1734 - 1741. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. S. Lee, Y. J. Jeong, J. Han, B.-T. Kim, H. Kim, and O J. Kwon T1 Non-Small Cell Lung Cancer: Imaging and Histopathologic Findings and Their Prognostic Implications RadioGraphics, November 1, 2004; 24(6): 1617 - 1636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Ikeda, J. Maeda, K. Yashima, M. Tsuboi, H. Kato, S. Akada, and S. Okada A clinicopathological study of resected adenocarcinoma 2 cm or less in diameter Ann. Thorac. Surg., September 1, 2004; 78(3): 1011 - 1016. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Matsuguma, R. Nakahara, M. Anraku, T. Kondo, Y. Tsuura, Y. Kamiyama, K. Mori, and K. Yokoi Objective definition and measurement method of ground-glass opacity for planning limited resection in patients with clinical stage IA adenocarcinoma of the lung Eur. J. Cardiothorac. Surg., June 1, 2004; 25(6): 1102 - 1106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Takamochi, J. Yoshida, M. Nishimura, T. Yokose, S. Sasaki, Y. Nishiwaki, K. Suzuki, and K. Nagai Prognosis and histologic features of small pulmonary adenocarcinoma based on serum carcinoembryonic antigen level and computed tomographic findings Eur. J. Cardiothorac. Surg., May 1, 2004; 25(5): 877 - 883. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Nomori, T. Ohtsuka, T. Naruke, and K. Suemasu Histogram analysis of computed tomography numbers of clinical T1 N0 M0 lung adenocarcinoma, with special reference to lymph node metastasis and tumor invasiveness J. Thorac. Cardiovasc. Surg., November 1, 2003; 126(5): 1584 - 1589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Nomori, T. Ohtsuka, T. Naruke, and K. Suemasu Differentiating between atypical adenomatous hyperplasia and bronchioloalveolar carcinoma using the computed tomography number histogram Ann. Thorac. Surg., September 1, 2003; 76(3): 867 - 871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Barlesi, C. Doddoli, C. Gimenez, B. Chetaille, R. Giudicelli, P. Fuentes, J.-P. Kleisbauer, and P. Thomas Bronchioloalveolar carcinoma: myths and realities in the surgical management Eur. J. Cardiothorac. Surg., July 1, 2003; 24(1): 159 - 164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Higashiyama, K. Kodama, K. Takami, N. Higaki, T. Nakayama, and H. Yokouchi Intraoperative lavage cytologic analysis of surgical margins in patients undergoing limited surgery for lung cancer J. Thorac. Cardiovasc. Surg., January 1, 2003; 125(1): 101 - 107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. I. Ebright, M. F. Zakowski, J. Martin, E. S. Venkatraman, V. A. Miller, M. S. Bains, R. J. Downey, R. J. Korst, M. G. Kris, and V. W. Rusch Clinical pattern and pathologic stage but not histologic features predict outcome for bronchioloalveolar carcinoma Ann. Thorac. Surg., November 1, 2002; 74(5): 1640 - 1647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Dong, M. Sato, M. Sagawa, C. Endo, K. Usuda, A. Sakurada, S. Wu, T. Oyaizu, I. Ishida, M. Handa, et al. Computed tomographic image comparison between mediastinal and lung windows provides possible prognostic information in patients with small peripheral lung adenocarcinoma J. Thorac. Cardiovasc. Surg., November 1, 2002; 124(5): 1014 - 1020. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Seki, T. Takasu, K. Mandai, M. Nakata, H. Saeki, Y. Heike, I. Takata, Y. Segawa, T. Hanafusa, and K. Eguchi Expression of Eukaryotic Initiation Factor 4E in Atypical Adenomatous Hyperplasia and Adenocarcinoma of the Human Peripheral Lung Clin. Cancer Res., October 1, 2002; 8(10): 3046 - 3053. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Matsuguma, K. Yokoi, M. Anraku, T. Kondo, Y. Kamiyama, K. Mori, K. Tominaga, Y. Tsuura, and S. Honjo Proportion of ground-glass opacity on high-resolution computed tomography in clinical T1 N0 M0 adenocarcinoma of the lung: A predictor of lymph node metastasis J. Thorac. Cardiovasc. Surg., August 1, 2002; 124(2): 278 - 284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-i. Watanabe, T. Watanabe, K. Arai, T. Kasai, J. Haratake, and H. Urayama Results of wedge resection for focal bronchioloalveolar carcinoma showing pure ground-glass attenuation on computed tomography Ann. Thorac. Surg., April 1, 2002; 73(4): 1071 - 1075. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. A. Kim, T. Johkoh, K. S. Lee, J. Han, K. Fujimoto, J. Sadohara, P. S. Yang, T. Kozuka, O. Honda, and S. Kim Quantification of Ground-Glass Opacity on High-Resolution CT of Small Peripheral Adenocarcinoma of the Lung: Pathologic and Prognostic Implications Am. J. Roentgenol., December 1, 2001; 177(6): 1417 - 1422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Sawabata, H. Maeda, M. Ohta, and M. Hayakawa Operable Non-small Cell Lung Cancer Diagnosed by Transpleural Techniques : Do They Affect Relapse and Prognosis? Chest, November 1, 2001; 120(5): 1595 - 1598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Carretta, B. Canneto, G. Calori, G. L. Ceresoli, E. Campagnoli, G. Arrigoni, A. Vagani, and P. Zannini Evaluation of radiological and pathological prognostic factors in surgically-treated patients with bronchoalveolar carcinoma Eur. J. Cardiothorac. Surg., August 1, 2001; 20(2): 367 - 371. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Takamochi, K. Nagai, J. Yoshida, K. Suzuki, Y. Ohde, M. Nishimura, S. Sasaki, and Y. Nishiwaki Pathologic N0 status in pulmonary adenocarcinoma is predictable by combining serum carcinoembryonic antigen level and computed tomographic findings J. Thorac. Cardiovasc. Surg., August 1, 2001; 122(2): 325 - 330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Higashiyama, K. Kodama, H. Yokouchi, K. Takami, T. Nakayama, and T. Horai A novel test of the surgical margin in patients with lung cancer undergoing limited surgery: Lavage cytologic technique J. Thorac. Cardiovasc. Surg., August 1, 2000; 120(2): 412 - 413. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
