ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lefer, A. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lefer, A. M.

Ann Thorac Surg 1999;68:1920-1923
© 1999 The Society of Thoracic Surgeons

I. Pathophysiology of Ischemic Reperfusion Injury

Role of the ß2-integrins and immunoglobulin superfamily members in myocardial ischemia-reperfusion

Allan M. Lefer, PhDa

a Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

Address reprint requests to Dr Lefer, Department of Physiology, Jefferson Medical College, 1020 Locust St, Philadelphia, PA 19107;
e-mail: allan.m.lefer{at}mail.tju.edu

Presented at the International Symposium on Myocardial Protection From Surgical Ischemic-Reperfusion Injury, Asheville, NC, Sep 21–24, 1997.

Abstract

Leukocytes play a key role in the inflammatory processes such as ischemia-reperfusion of the coronary vasculature. Their interaction with the endothelium is closely regulated. The first step in the process is the rolling of leukocytes (eg, neutrophils) along the microvascular endothelium. This is regulated by the selectin family of cell adhesion molecules, primarily P-selectin. The next step in the inflammatory cascade is the firm adhesion of these neutrophils to the activated or dysfunctional endothelium. This process is governed by the ß2-integrins on the leukocytes (eg, CD11/CD18) and by ICAM-1 on the activated endothelium. CD11/CD18 is a ß2-integrin, and ICAM-1 is a member of the immunoglobulin superfamily of adhesion glycoproteins. By their interaction, neutrophils flatten out and adhere to the vascular endothelium. Many of these adhered neutrophils are then able to transmigrate across the endothelium to the site of the inflammation (ie, the focus of the ischemia-reperfusion). This transmigration is primarily stimulated by PECAM-1, another member of the immunoglobulin superfamily. These processes are discussed in this brief review.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. H. Merchant, D. M. Gurule, and R. S. Larson
Amelioration of ischemia-reperfusion injury with cyclic peptide blockade of ICAM-1
Am J Physiol Heart Circ Physiol, April 1, 2003; 284(4): H1260 - H1268.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
L. M. Riou, M. Ruiz, G. W. Sullivan, J. Linden, H. Leong-Poi, J. R. Lindner, T. D. Harris, G. A. Beller, and D. K. Glover
Assessment of Myocardial Inflammation Produced by Experimental Coronary Occlusion and Reperfusion With 99mTc-RP517, a New Leukotriene B4 Receptor Antagonist That Preferentially Labels Neutrophils In Vivo
Circulation, July 30, 2002; 106(5): 592 - 598.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
Q.-D. Wang, J. Pernow, P.-O. Sjoquist, and L. Ryden
Pharmacological possibilities for protection against myocardial reperfusion injury
Cardiovasc Res, July 1, 2002; 55(1): 25 - 37.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
S. Y. Yuan, M. H. Wu, E. E. Ustinova, M. Guo, J. H. Tinsley, P. de Lanerolle, and W. Xu
Myosin Light Chain Phosphorylation in Neutrophil-Stimulated Coronary Microvascular Leakage
Circ. Res., June 14, 2002; 90(11): 1214 - 1221.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
R. A. Bowden, Z.-M. Ding, E. M. Donnachie, T. K. Petersen, L. H. Michael, C. M. Ballantyne, and A. R. Burns
Role of {alpha}4 Integrin and VCAM-1 in CD18-Independent Neutrophil Migration Across Mouse Cardiac Endothelium
Circ. Res., March 22, 2002; 90(5): 562 - 569.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
S. C. Stoica, M. Goddard, and S. R. Large
The endothelium in clinical cardiac transplantation
Ann. Thorac. Surg., March 1, 2002; 73(3): 1002 - 1008.
[Abstract] [Full Text] [PDF]

Home page
 PerfusionHome page
G. A Ortolano, G. S Aldea, K. Lilly, P. O'Gara, J. D Alkon, F. Madera, T. Murad, C. P Altenbern, C. S Tritt, A. Capetandes, et al.
A review of leukofiltration in cardiac surgery: the time course of reperfusion injury may facilitate study design of anti-inflammatory effects
Perfusion, March 1, 2002; 17(2_suppl): 53 - 62.
[Abstract] [PDF]

Home page
 Eur Heart J SupplHome page
J. Pernow, A.T. Gonon, and A. Gourine
The role of the endothelium for reperfusion injury
Eur. Heart J. Suppl., June 1, 2001; 3(suppl_C): C22 - C27.
[Abstract] [PDF]

Home page
 Circ. Res.Home page
R. A. Bowden, Z.-M. Ding, E. M. Donnachie, T. K. Petersen, L. H. Michael, C. M. Ballantyne, and A. R. Burns
Role of {alpha}4 Integrin and VCAM-1 in CD18-Independent Neutrophil Migration Across Mouse Cardiac Endothelium
Circ. Res., March 22, 2002; 90(5): 562 - 569.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1999 by The Society of Thoracic Surgeons.