| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 1999;68:1898-1904
© 1999 The Society of Thoracic Surgeons
a Departments of Pharmacology and Toxicology, and Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Address reprint requests to Dr Gross, Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226
e-mail: ggross{at}post.its.mcw.edu
Presented at the International Symposium on Myocardial Protection From Surgical Ischemic-Reperfusion Injury, Asheville, NC, Sept 21–24, 1997.
Abstract
Prolonged reversible postischemic contractile dysfunction that follows single or multiple brief periods of regional or global ischemia has been termed "stunned myocardium," and is thought to be the result of a decreased responsiveness of the cardiac myofilaments to calcium. A number of hypotheses have been proposed to explain the pathogenesis of stunned myocardium; however, the two major theories that are supported by the most experimental evidence suggest that the generation of oxygen-derived free radicals and a disturbance in calcium homeostasis are responsible for the postischemic contractile dysfunction observed. These mechanisms are not mutually exclusive, and data are available that support both theories. Evidence exists that indicates that one may pharmacologically enhance the recovery of stunned myocardium by use of oxygen radical scavengers, adenosine agonists, calcium channel blockers, and openers of the ATP-sensitive potassium channel, including the volatile anesthetic isoflurane. Ischemic preconditioning (IPC) has also been shown to produce delayed protection against myocardial stunning, and a novel pharmacological agent, monophosphoryl lipid A, has been shown to mimic the effect of IPC. Because stunning appears to occur in a number of clinical settings, it is important to understand the mechanisms involved and to develop pharmacological therapy that will result in an improved clinical outcome.
This article has been cited by other articles:
|
|
 |
|
  M.A. H. Talukder, J. L. Zweier, and M. Periasamy Targeting calcium transport in ischaemic heart disease Cardiovasc Res, August 17, 2009; (2009) cvp264v2. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Abdel-Rahman, P. Risteski, K. Tizi, S. Kerscher, S. Bejati, K. Zwicker, M. Scholz, U. Brandt, and A. Moritz Hypoxic reoxygenation during initial reperfusion attenuates cardiac dysfunction and limits ischemia-reperfusion injury after cardioplegic arrest in a porcine model J. Thorac. Cardiovasc. Surg., April 1, 2009; 137(4): 978 - 982. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. H. Talukder, A. Kalyanasundaram, L. Zuo, M. Velayutham, Y. Nishijima, M. Periasamy, and J. L. Zweier Is reduced SERCA2a expression detrimental or beneficial to postischemic cardiac function and injury? Evidence from heterozygous SERCA2a knockout mice Am J Physiol Heart Circ Physiol, March 1, 2008; 294(3): H1426 - H1434. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Healy, A. E. Wood, A. O'Neill, J. F. McCarthy, J. M. Fitzpatrick, and R. W. Watson Can preoperative modelling of individual neutrophil adhesion responses predict renal morbidity? Eur. J. Cardiothorac. Surg., June 1, 2007; 31(6): 1088 - 1093. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Zweier and M.A. H. Talukder The role of oxidants and free radicals in reperfusion injury Cardiovasc Res, May 1, 2006; 70(2): 181 - 190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Castella, G. D. Buckberg, and S. Saleh Diastolic dysfunction in stunned myocardium: a state of abnormal excitation-contraction coupling that is limited by Na+-H+ exchange inhibition Eur. J. Cardiothorac. Surg., April 1, 2006; 29(Suppl_1): S107 - S114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. T. Mallet, J. Sun, E. M. Knott, A. B. Sharma, and A. H. Olivencia-Yurvati Metabolic Cardioprotection by Pyruvate: Recent Progress Experimental Biology and Medicine, July 1, 2005; 230(7): 435 - 443. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. G. De Hert, F. Turani, S. Mathur, and D. F. Stowe Cardioprotection with Volatile Anesthetics: Mechanisms and Clinical Implications Anesth. Analg., June 1, 2005; 100(6): 1584 - 1593. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Nikolaidis, A. Doverspike, T. Hentosz, L. Zourelias, Y.-T. Shen, D. Elahi, and R. P. Shannon Glucagon-Like Peptide-1 Limits Myocardial Stunning following Brief Coronary Occlusion and Reperfusion in Conscious Canines J. Pharmacol. Exp. Ther., January 1, 2005; 312(1): 303 - 308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Asemu, N. S. Dhalla, and P. S. Tappia Inhibition of PLC improves postischemic recovery in isolated rat heart Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2598 - H2605. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. M. Palatianos, G. Balentine, E. G. Papadakis, C. D. Triantafillou, M. I. Vassili, A. Lidoriki, A. Dinopoulos, and G. M. Astras Neutrophil depletion reduces myocardial reperfusion morbidity Ann. Thorac. Surg., March 1, 2004; 77(3): 956 - 961. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Klass, U. M. Fischer, E. Perez, J. Easo, M. Bosse, J. H. Fischer, P. Tossios, and U. Mehlhorn Effect of the Na+/H+ exchange inhibitor eniporide on cardiac performance and myocardial high energy phosphates in pigs subjected to cardioplegic arrest Ann. Thorac. Surg., February 1, 2004; 77(2): 658 - 663. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. o. Cosar and C. J. O'Connor Hibernation, Stunning, and Preconditioning: Historical Perspective, Current Concepts, Clinical Applications, and Future Implications Seminars in Cardiothoracic and Vascular Anesthesia, June 1, 2003; 7(2): 115 - 140. [Abstract] [PDF]
|
|
|
|
 |
|
 R. Kohen and A. Nyska Invited Review: Oxidation of Biological Systems: Oxidative Stress Phenomena, Antioxidants, Redox Reactions, and Methods for Their Quantification Toxicol Pathol, October 1, 2002; 30(6): 620 - 650. [Abstract] [PDF]
|
|
|
|
|
|
D. Wu, Y. Soong, G.-M. Zhao, and H. H. Szeto A highly potent peptide analgesic that protects against ischemia-reperfusion-induced myocardial stunning Am J Physiol Heart Circ Physiol, August 1, 2002; 283(2): H783 - H791. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Verma, P. W.M. Fedak, R. D. Weisel, J. Butany, V. Rao, A. Maitland, R.-K. Li, B. Dhillon, and T. M. Yau Fundamentals of Reperfusion Injury for the Clinical Cardiologist Circulation, May 21, 2002; 105(20): 2332 - 2336. [Full Text] [PDF]
|
|
|
|
|
|
U. Sunderdiek, S. Schmitz-Spanke, B. Korbmacher, E. Gams, and J. D. Schipke Left ventricular dysfunction and disturbed O2-utilization in stunned myocardium: influence of ischemic preconditioning Eur. J. Cardiothorac. Surg., October 1, 2001; 20(4): 770 - 776. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Yao, R. Kato, and P. Foex Isoflurane-induced protection against myocardial stunning is independent of adenosine 1 (A1) receptor in isolated rat heart Br. J. Anaesth., August 1, 2001; 87(2): 258 - 265. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
