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Ann Thorac Surg 1999;68:1751-1755
© 1999 The Society of Thoracic Surgeons

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Original Articles

IL-6 and IL-8 levels after cardiopulmonary bypass are not affected by surface coating

^a Cardiac Surgical Unit, Royal Children’s Hospital, Melbourne, Australia
^b Intensive Care Unit, Royal Children’s Hospital, Melbourne, Australia
^c Pathology Department, Royal Melbourne Hospital, Melbourne, Australia

Address reprint requests to Dr Karl, Cardiac Surgical Unit, Royal Children’s Hospital, Flemington Rd, Parkville, 3052 Victoria, Australia
e-mail: cardiac{at}cryptic.rch.unimelb.edu.au

Background. Contact of blood with the surfaces of the cardiopulmonary bypass (CPB) circuit has been implicated as a cause of the inflammatory response. We undertook a prospective randomized trial of 200 pediatric patients, all with a calculated total bypass flow of less than 2.3 L/min (< 0.96 L/m²/min).

Methods. Patients were randomly assigned to 1 of 4 CPB groups: (1) Nonheparin-bonded circuit with no albumin preprime; (2) Nonheparin-bonded circuit with albumin preprime; (3) Heparin-bonded circuit with no albumin preprime; (4) Heparin-bonded circuit with albumin preprime. Measurements of cytokines, (interleukin [IL]-6, IL-8) and blood cell counts were made prebypass and 6 and 24 hours after institution of cardiopulmonary bypass.

Results. Analysis of variance showed no significant difference in any of the clinical or biochemical characteristics of the 4 groups. The interaction between heparin-bonded oxygenators and albumin preprime was not significant. No important differences in IL-6 or IL-8 concentrations were noted after CPB using either heparin or nonheparin-bonded oxygenators with albumin or albumin free preprime using two-way analysis of variance.

Conclusions. Albumin preprime and heparin-bonding do not attenuate the inflammatory response component attributable to the concentration of these markers.

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