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Ann Thorac Surg 1999;68:1410-1411
© 1999 The Society of Thoracic Surgeons

Case Reports

Early fungal endocarditis in homograft recipients

Paul A. Fedalen, MDa,c, Carol A. Fisher, BAa,c, Barbara A. Todd, MSNa,c,d, Paul J. Mather, MDb,c, V. Paul Addonizio, MDa,c,d

a Division of Cardiac and Thoracic Surgery, Philadelphia, Pennsylvania, USA
b Department of Cardiology, Philadelphia, Pennsylvania, USA
c Temple University Health Sciences Center, Philadelphia, Pennsylvania, USA
d Abington Memorial Hospital, Philadelphia, Pennsylvania, USA

Address reprint requests to Dr Addonizio, Division of Cardiac and Thoracic Surgery, Temple University Health Sciences Center, 300 Parkinson Pavilion, 3401 N Broad St, Philadelphia, PA 19140

Retrospective analysis of 200 homograft valve recipients at our institution revealed two cases of fungal endocarditis. Pathogenesis appears to be related to either recipient seeding in one elderly immunocompromised patient or a previously contaminated donor valve implanted in an otherwise healthy recipient. Therefore, our experience underscores the need for both meticulous prevention of fungal infection preoperatively in the recipient and elimination of previously contaminated homograft valves from the donor pool.




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