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Ann Thorac Surg 1999;68:1072-1074
© 1999 The Society of Thoracic Surgeons

Case Reports

Procainamide-induced postoperative pyrexia

Kevin D. Murray, MDa, Jon J. Vlasnik, PharmDa

a Division of Cardiothoracic Surgery, Washington University School of Medicine, and Department of Pharmacology, Barnes-Jewish Hospital, St. Louis, Missouri, USA

Address reprint requests to Dr Murray, Division of Cardiothoracic Surgery, University of Nevada School of Medicine, 2040 W Charleston Blvd, Suite 601, Las Vegas, NV 89102
e-mail: kmurray{at}med.unr.edu

Procainamide is an effective antiarrhythmic that is often used to convert atrial fibrillation to normal sinus rhythm. A side effect of procainamide, rarely reported in the surgical literature, is pyrexia. The pyrexia is a manifestation of an allergic response to this medication. If unrecognized, procainamide-induced pyrexia can lead to unnecessary testing, hospitalization, and treatment. We present a case of a post-coronary artery bypass surgery patient who repeatedly displayed pyrexia when reexposed to procainamide indicating an allergic response to this drug.






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