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Ann Thorac Surg 1999;67:1765-1770
© 1999 The Society of Thoracic Surgeons
a Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
b Department of Obstetrics and Gynecology, University of Helsinki, Helsinki, Finland
Accepted for publication December 24, 1998.
Address reprint requests to Dr Pesonen, Hospital for Children and Adolescents, Stenbäckinkatu 11, 00290 Helsinki, Finland
e-mail: epesonen{at}helsinki.fi
Background. Clinical studies of deep hypothermic circulatory arrest (DHCA) have focused only on the immediate postoperative period. However, experimental findings suggest impairment of cerebral oxygenation at 2 to 8 hours after reperfusion.
Methods. In 10 children who had DHCA for heart operations, transcerebral differences of hemoglobin oxygen saturation and plasma hypoxanthine, xanthine, and lactoferrin concentrations were measured in concurrently obtained cerebral venous, arterial, and mixed venous samples up to 10 hours postoperatively.
Results. Compared with preoperative levels (57% ± 7%), cerebral venous oxygen saturation was not significantly reduced until 2 hours (44% ± 6%) and 6 hours (42% ± 5%) after DHCA (p < 0.05). A statistically significant transcerebral (ie, cerebral vein versus artery) concentration difference of hypoxanthine was observed at 30 minutes (3.6 ± 0.9 µmol/L), 1 hour (3.4 ± 1.1 µmol/L), and 2 hours (3.1 ± 0.8 µmol/L) after DHCA but not preoperatively (0.4 ± 0.2 µmol/L). A transcerebral concentration difference of lactoferrin occurred 30 minutes after DHCA (196 ± 70 µg/mL) but not preoperatively (16 ± 20 µg/mL).
Conclusions. Cerebral venous oxygen saturation of hemoglobin decreased as late as 2 to 6 hours after DHCA, in association with impaired cerebral energy status. Neutrophil activation in the cerebral circulation occurred 30 minutes after reperfusion.
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