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Ann Thorac Surg 1999;67:1315-1319
© 1999 The Society of Thoracic Surgeons

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Original Articles

Biocompatibility of a silicone-coated polypropylene hollow fiber oxygenator in an in vitro model

^a Department of Thoracic and Cardiovascular Surgery, Niigata University School of Medicine, Niigata, Japan

Accepted for publication November 12, 1998.

Address reprint requests to Dr Watanabe, Department of Thoracic and Cardiovascular Surgery, Niigata University School of Medicine, 757 Asahimachi-dohri 1, Niigata City 951, Japan
e-mail: watanabe{at}med.niigata-u.ac.jp

Background. A silicone-coated microporous hollow-fiber membrane oxygenator has been developed to prevent plasma leakage during long-term use. The objective of this study was to evaluate the biocompatibility of the oxygenator.

Methods. A silicone-coated oxygenator was compared with an uncoated oxygenator in an in vitro model of cardiopulmonary bypass. Simulated circulation was maintained for 6 h at 37°C.

Results. Platelet counts decreased significantly (p < 0.05) and leukocyte counts tended to decline; however, the differences between groups were not significant. Concentrations of C3a increased significantly in both groups (p < 0.05), but levels were significantly less in the silicone-coated oxygenator (p = 0.008). In contrast, concentrations of C4a, ß-thromboglobulin, and granulocyte elastase increased significantly (p < 0.05), but the differences between groups were not significant.

Conclusions. Silicone coating over a microporous hollow-fiber membrane may improve biocompatibility by reducing C3a activation.

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