| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 1999;67:972-977
© 1999 The Society of Thoracic Surgeons
a Department of Thoracic and Cardiovascular Surgery, Hôpital Henri Mondor, Créteil, France
b Service d’Immunologie Biologique, Hôpital Henri Mondor, Créteil, France
c Department of Cardiac Surgery, Free University Hospital, Amsterdam, the Netherlands
Accepted for publication September 4, 1998.
Address reprint requests to Dr Loisance, Department of Thoracic and Cardiovascular Surgery, Hôpital Henri Mondor, 51 Avenue du Mal de Lattre de Tassigny, 94010 Créteil Cedex, France
e-mail: loisance{at}univ-paris12.fr
Background. The inflammatory response in 29 patients undergoing coronary artery bypass grafting using either roller or centrifugal (CFP) pumps was evaluated in a prospective study.
Methods. Patients were randomized in roller pump (n = 15) and CFP (n = 14) groups. Terminal complement complex activation (SC5b-9) and neutrophil activation (elastase) were assessed during the operation. Cytokine production (tumor necrosis factor-
, interleukin-6, interleukin-8) and circulating adhesion molecules (soluble endothelial-leukocyte adhesion molecule-1 and intercellular adhesion molecule-1) were assessed after the operation.
Results. Release of SC5b-9 after stopping cardiopulmonary bypass and after protamine administration was higher in the CFP group (p = 0.01 and p = 0.004). Elastase level was higher after stopping cardiopulmonary bypass using CFP (p = 0.006). Multivariate analysis confirmed differences between roller pump and CFP groups in complement and neutrophil activation. After the operation, a significant production of cytokines was detected similarly in both groups, with peak values observed within the range of 4 to 6 hours after starting cardiopulmonary bypass. However, interleukin-8 levels were higher using CFP 2 hours after starting cardiopulmonary bypass (p = 0.02). Plasma levels of adhesion molecules were similar in both groups within the investigation period.
Conclusions. During the operation, CFP caused greater complement and neutrophil activation. After the operation, the inflammatory response was similar using either roller pump or CFP.
This article has been cited by other articles:
|
|
 |
|
  J. W. Hammon Extracorporeal Circulation: Perfusion System Card. Surg. Adult, January 1, 2008; 3(2008): 350 - 370. [Full Text]
|
|
|
|
 |
|
 Y Ganushchak, W van Marken Lichtenbelt, T van der Nagel, and D S de Jong Hydrodynamic performance and heat generation by centrifugal pumps. Perfusion, November 1, 2006; 21(6): 373 - 379. [Abstract] [PDF]
|
|
|
|
 |
|
 J. Asante-Siaw, J. Tyrrell, A. Hoschtitzky, and J. Dunning Does the use of a centrifugal pump offer any additional benefit for patients having open heart surgery? Interactive CardioVascular and Thoracic Surgery, April 1, 2006; 5(2): 128 - 134. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Baufreton More Biocompatibility in Cardiopulmonary Bypass for High-Risk Patients Ann. Thorac. Surg., February 1, 2006; 81(2): 790 - 791. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Boning, J. Scheewe, T. Ivers, C. Friedrich, J. Stieh, S. Freitag, and J. T. Cremer Phosphorylcholine or heparin coating for pediatric extracorporeal circulation causes similar biologic effects in neonates and infants J. Thorac. Cardiovasc. Surg., May 1, 2004; 127(5): 1458 - 1465. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Anselmi, A. Abbate, F. Girola, G. Nasso, G. G.L. Biondi-Zoccai, G. Possati, and M. Gaudino Myocardial ischemia, stunning, inflammation, and apoptosis during cardiac surgery: a review of evidence Eur. J. Cardiothorac. Surg., March 1, 2004; 25(3): 304 - 311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Hessel II and L. H. Edmunds Jr. Extracorporeal Circulation: Perfusion Systems Card. Surg. Adult, January 1, 2003; 2(2003): 317 - 338. [Full Text]
|
|
|
|
 |
|
 P. Naughton and C. A. Bashour Mechanical Support After Cardiac Surgery Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2002; 6(3): 237 - 257. [Abstract] [PDF]
|
|
|
|
|
|
D. Paparella, T.M. Yau, and E. Young Cardiopulmonary bypass induced inflammation: pathophysiology and treatment. An update Eur. J. Cardiothorac. Surg., February 1, 2002; 21(2): 232 - 244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R A B. van Kempen, J M Gasiorek, K Bloemendaal, R P. S. van Leeuwen, and E R Bulder Low-prime perfusion circuit and autologous priming in CABG surgery on a Jehova's Witness: a case report Perfusion, January 1, 2002; 17(1): 69 - 72. [Abstract] [PDF]
|
|
|
|
|
|
C. R Holleyman and D. F Larson Apoptosis in the ischemic reperfused myocardium Perfusion, December 1, 2001; 16(6): 491 - 502. [Abstract] [PDF]
|
|
|
|
 |
|
 T J Spyt and A C De Souza Minimally invasive therapy and robotics: Treatments in ischaemic heart disease Br. Med. Bull., October 1, 2001; 59(1): 261 - 268. [Full Text] [PDF]
|
|
|
|
|
|
A. Parolari, F. Alamanni, M. Naliato, R. Spirito, V. Franze, G. Pompilio, M. Agrifoglio, and P. Biglioli Adult cardiac surgery outcomes: role of the pump type Eur. J. Cardiothorac. Surg., November 1, 2000; 18(5): 575 - 582. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
