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Ann Thorac Surg 1999;67:1158-1159
© 1999 The Society of Thoracic Surgeons

Case Reports

Nicorandil-induced peripheral vasodilatation during cardiopulmonary bypass

Bode A. Falase, FRCSa, Balwinder S. Bajaj, MRCPa, Tracey J. Wall, FRCAa, Vincenzo Argano, FRCSa, Aprim Y. Youhana, FRCSa

a Department of Cardiothoracic Surgery, Cardiology, and Anaesthetics, Regional Cardiac Centre, Morriston Hospital, Swansea, Wales, United Kingdom

Accepted for publication September 23, 1998.

Address reprint requests to Mr Falase, Department of Cardiothoracic Surgery, Regional Cardiac Centre, Morriston Hospital, Swansea, SA6 6NL, Wales, United Kingdom
e-mail: bode{at}bfalase.freeserve.co.uk

Nicorandil is an antianginal agent with actions at epicardial coronary arteries and arterioles, systemic arterioles, and veins. We report our experience with 7 patients taking oral Nicorandil who had severe vasodilation and hypotension requiring significant vasoconstrictor support after cardiopulmonary bypass. Although the mechanism for this phenomenon remains unknown Nicorandil might be interacting with other factors present during cardiopulmonary bypass, as it has relatively mild hemodynamic effects outside this situation.




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P. Blanc, A. Aouifi, H. Bouvier, P. Joseph, P. Chiari, M. Ovize, C. Girard, O. Jegaden, Y. Khder, and J. J. Lehot
Safety of oral nicorandil before coronary artery bypass graft surgery{dagger}
Br. J. Anaesth., December 1, 2001; 87(6): 848 - 854.
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