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Ann Thorac Surg 1999;67:851-852
© 1999 The Society of Thoracic Surgeons

Case Reports

Malignant melanoma presenting as a mediastinal mass

Christine L. Lau, MDa, Rex C. Bentley, MDb, Jon P. Gockerman, MDc, Loretta G. Que, MDc, Thomas A. D’Amico, MDa

a Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
b Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA
c Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA

Accepted for publication September 9, 1998.

Address reprint requests to Dr D’Amico, Department of Surgery, Duke University Medical Center, Box 3496, Durham, NC 27710
e-mail: damic001{at}mc.duke.edu

A case of malignant melanoma presenting as a mediastinal mass without an extrathoracic primary is reported. Microscopically the tumor appeared consistent with malignant melanoma, with the presence of focal melanin pigment in large epithelioid cells. Fontana stain confirmed the presence of melanin pigment. Immunohistochemical staining further suggested melanoma, with the tumor cells expressing a HMB45+, S100+ and cytokeratin-phenotype. Electron microscopy showed an abundance of melanosomes confirming the diagnosis of malignant melanoma.




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