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Ann Thorac Surg 1999;67:837-838
© 1999 The Society of Thoracic Surgeons

Case Reports

Severe anaphylactic reaction after primary exposure to aprotinin

Daniel M. Cohen, MDa, Jose Norberto, MDa, Richard Cartabuke, MDb, Grace Ryu, MDc

a Division of Cardiothoracic Surgery, Ohio State University College of Medicine and Children’s Hospital, Columbus, Ohio, USA
b Department of Anesthesiology, Ohio State University College of Medicine and Children’s Hospital, Columbus, Ohio, USA
c Department of Pediatrics, Ohio State University College of Medicine and Children’s Hospital, Columbus, Ohio, USA

Accepted for publication August 19, 1998.

Address reprint requests to Dr Cohen, Department of Thoracic Surgery, Children’s Hospital, 700 Children’s Dr, Columbus, OH 43205;
e-mail: cohend{at}chi.osu.edu

Aprotinin is widely used to prevent bleeding and reduce blood transfusions after open heart surgical procedures. Because it is a foreign protein, aprotinin has allergenic potential. We report a case of near-fatal anaphylactic reaction to primary aprotinin exposure in a child successfully treated using cardiopulmonary bypass support. The possibility of an allergic reaction must be considered whenever this drug is used.




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