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Ann Thorac Surg 1999;67:810-814
© 1999 The Society of Thoracic Surgeons

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Original Articles

MUC1 mucin mRNA expression in stage I lung adenocarcinoma and its association with early recurrence

^a Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan
^b Department of Surgery II, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan

Accepted for publication August 14, 1998.

Address reprint requests to Dr Ohgami, Department of Environmental Health Engineering, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan
e-mail: gamisan{at}med.uoeh-u.ac.jp

Background. MUC1 is a membrane-bound mucin with an extensively O-glycosylated core protein and is developmentally regulated and aberrantly expressed by carcinomas. A high level of MUC1 mucin expression and secretion is associated with high metastatic potential and a poor prognosis. We studied the expression of MUC1 messenger ribonucleic acid (mRNA) in stage I lung adenocarcinoma by reverse transcriptase–polymerase chain reaction and examined its correlation with early recurrence.

Methods. The expression of MUC1 mRNA, in surgical specimens from 33 patients with stage I lung adenocarcinoma was determined by reverse transcriptase–polymerase chain reaction. The MUC1 and ß-actin sequences were subsequently coamplified to analyze the semiquantitative determination by polymerase chain reaction. The ratio of MUC1 to ß-actin product was used for further analysis.

Results. An analysis of the disease-free survival (median follow-up, 33.4 months) revealed that a high expression of MUC1 was associated with early recurrence (p = 0.0191). Six of the 33 patients had recurrence within 2 years after operation. The recurrence sites suggested hematogenic metastasis.

Conclusions. Our results indicate that MUC1 mRNA level may be useful as a marker of early recurrence in stage I lung adenocarcinoma.

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