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Ann Thorac Surg 1999;67:446-449
© 1999 The Society of Thoracic Surgeons

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Original Articles

Decreased incidence of arterial thrombosis using heparin-bonded intraaortic balloons

^a Department of Cardiothoracic Surgery, The Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts, USA

Accepted for publication July 8, 1998.

Address reprint requests to Dr Lazar, Department of Cardiothoracic Surgery, The Boston Medical Center, 88 East Newton St, Suite B404, Boston, MA 02118

Background. This experimental study sought to determine whether heparin-bonding of intraaortic balloons (IAB) would decrease the incidence of arterial thrombosis in the absence of systemic heparinization.

Methods. In 25 adult pigs, a 9F, 40-mL IAB was inserted into the femoral artery and positioned just below the takeoff of the left subclavian artery for 9 hours. Five animals received systemic heparin, 10 animals had no heparin, and another 10 animals received no heparin but the IAB was heparin-bonded (Duraflo II). Thrombus formation was assessed using a numerical scoring system (0 = no thrombosis to 3 = thrombus >5 cm or evidence of luminal compromise).

Results. Animals receiving heparin and heparin-bonded IAB had no thrombus formation around the IAB (mean ± SE; 0 ± 0.00 heparin versus 1.55 ± 0.29 no heparin versus 0 ± 0.00 heparin-bonded; p < 0.005), at the insertion site (0 ± 0.00 heparin versus 1.55 ± 0.29 no heparin versus 0 ± 0.0 heparin-bonded; p < 0.005), and in the distal femoral artery (0 ± 0.00 heparin versus 2.00 ± 0.23 no heparin versus 0 ± 0.00 heparin-bonded; p < 0.005).

Conclusions. Heparin-bonding of the IAB significantly decreases thrombus formation in the absence of systemic heparinization.

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