| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 1999;67:208-211
© 1999 The Society of Thoracic Surgeons
a Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
b Department of Pathology II, Nagoya City University Medical School, Nagoya, Japan
Accepted for publication June 18, 1998.
Address reprint requests to Dr Fukai, Department of Surgery II, Nagoya City University Medical School, Mizuho-ku, Nagoya, 467-8601, Japan
e-mail: i.fukai{at}med.nagoya-cu.ac.jp
Background. Thymic neuroendocrine tumor (carcinoid tumor) is rare, and prognosis for patients with this tumor has been difficult to predict.
Methods. The medical records of 15 patients were reviewed, and the patients were classified according to tentative TNM classification and histologic grade.
Results. Ten (66.7%) of 15 patients were male. Lymph node metastases were identified in 9 (60%) of 15 patients at the time of resection. There were one grade 1, nine grade 2, and five grade 3 tumors. Total resection was possible in 13 patients. Distant metastases developed in 10 (76.9%) of these 13 patients, although no local recurrence developed. Of these 10 patients, 6 died of distant metastases 5 to 25 months after the recurrence. Three patients are still alive, with metastases to the bone, spleen, and pleura 1 to 24 months after the diagnosis of recurrence. Two patients are presently tumor free (T1N0, grade 3 and T3N2, grade 2), but only 1 has survived beyond 5 years.
Conclusions. Thymic neuroendocrine tumor must be regarded as a malignant neoplasm that is prone to metastasize to mediastinal lymph nodes and to distant sites, even after total excision. Neither T and N classification nor histologic grade has been successful in predicting the outcome of a patient with this tumor. More aggressive management, including adjuvant therapies and reexcision of subsequent tumors, may result in increased survival.
This article has been cited by other articles:
|
|
 |
|
  T. J. Haddad, R. Reddy, L. Green, and K. Velamuri THYMIC CARCINOID TUMOR PRESENTING AS A POSTERIOR MEDIASTINAL MASS Chest Meeting Abstracts, October 1, 2006; 130(4): 333S - 333S. [Abstract] [PDF]
|
|
|
|
 |
|
 F. C. Detterbeck and A. M. Parsons Thymic tumors Ann. Thorac. Surg., May 1, 2004; 77(5): 1860 - 1869. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. L. Filosso, G. M. Actis Dato, E. Ruffini, S. Bretti, F. Ozzello, and M. Mancuso Multidisciplinary treatment of advanced thymic neuroendocrine carcinoma (carcinoid): Report of a successful case and review of the literature J. Thorac. Cardiovasc. Surg., April 1, 2004; 127(4): 1215 - 1219. [Full Text] [PDF]
|
|
|
|
|
|
M.-H. Wu, Y.-L. Tseng, F.-F. Cheng, and T.-S. Lin Thymic carcinoid combined with myasthenia gravis J. Thorac. Cardiovasc. Surg., February 1, 2004; 127(2): 584 - 585. [Full Text] [PDF]
|
|
|
|
|
|
K. Kondo and Y. Monden Therapy for thymic epithelial tumors: a clinical study of 1,320 patients from Japan Ann. Thorac. Surg., September 1, 2003; 76(3): 878 - 884. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Tiffet, A. G. Nicholson, G. Ladas, M. N. Sheppard, and P. Goldstraw A Clinicopathologic Study of 12 Neuroendocrine Tumors Arising in the Thymus Chest, July 1, 2003; 124(1): 141 - 146. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Gibril, Y.-J. Chen, D. S. Schrump, A. Vortmeyer, Z. Zhuang, I. A. Lubensky, J. C. Reynolds, A. Louie, L. K. Entsuah, K. Huang, et al. Prospective Study of Thymic Carcinoids in Patients with Multiple Endocrine Neoplasia Type 1 J. Clin. Endocrinol. Metab., March 1, 2003; 88(3): 1066 - 1081. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Chaer, M. G. Massad, A. Evans, N. J. Snow, and A. S. Geha Primary neuroendocrine tumors of the thymus Ann. Thorac. Surg., November 1, 2002; 74(5): 1733 - 1740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-C. Liu, W.-H. Hsu, Y.-J. Chen, Y.-J. Chan, Y.-C. Wu, B.-S. Huang, and M.-H. Huang Primary thymic carcinoma Ann. Thorac. Surg., April 1, 2002; 73(4): 1076 - 1081. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. de Perrot, A. Spiliopoulos, S. Fischer, M. Totsch, and S. Keshavjee Neuroendocrine carcinoma (carcinoid) of the thymus associated with Cushing's syndrome Ann. Thorac. Surg., February 1, 2002; 73(2): 675 - 681. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Sakuragi, K. Rikitake, M. Nastuaki, and T. Itoh Complete resection of recurrent thymic carcinoid using cardiopulmonary bypass Eur. J. Cardiothorac. Surg., January 1, 2002; 21(1): 152 - 154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Gal, M. J. Kornstein, C. Cohen, I. G. Duarte, J. I. Miller, and K. A. Mansour Neuroendocrine tumors of the thymus: a clinicopathological and prognostic study Ann. Thorac. Surg., October 1, 2001; 72(4): 1179 - 1182. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Jaretzki III, R. J. Barohn, R. M. Ernstoff, H. J. Kaminski, J. C. Keesey, A. S. Penn, and D. B. Sanders Myasthenia gravis: Recommendations for clinical research standards Neurology, July 12, 2000; 55(1): 16 - 23. [Full Text] [PDF]
|
|
|
|
|
|
A. Jaretzki III, R. J. Barohn, R. M. Ernstoff, H. J. Kaminski, J. C. Keesey, A. S. Penn, and D. B. Sanders Myasthenia gravis: recommendations for clinical research standards Ann. Thorac. Surg., July 1, 2000; 70(1): 327 - 334. [Full Text] [PDF]
|
|
|
|
|
|
M. R. Wick and J. H. Ritter Thymic neuroendocrine tumors: : A commentary with current perspectives on neuroendocrine neoplasia Ann. Thorac. Surg., January 1, 1999; 67(1): 7 - 9. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
